Assessment of health risks with reference to oxidative stress and DNA damage in chromium exposed population

Khan, Faizan Haider; Ambreen, Khushboo; Fatima, Ghizal; Kumar, Sudhir

doi:10.1016/j.scitotenv.2012.04.063

Cited by 50 publications

(30 citation statements)

References 38 publications

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“…The adsorption edge experiments were conducted under atmospheric conditions at different solution pH (3)(4)(5)(6)(7)(8)(9)(10), total Cr(VI) concentrations (10 -4 , 10 -5 , and 10 -6 M) and ionic strengths (using 0.001, 0.01, and 0.1 M KNO3 as the background electrolyte). Ferrihydrite (2 g/L), birnessite (20 g/L), kaolinite (20 g/L), and illite (20 g/L) were added to the 500 mL solution containing Cr(VI) and the background electrolyte.…”

Section: Samples For Adsorption Modelingmentioning

confidence: 99%

See 1 more Smart Citation

Chromate adsorption on selected soil minerals: Surface complexation modeling coupled with spectroscopic investigation

Veselská

Fajgаr

Číhalová

et al. 2016

Journal of Hazardous Materials

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Section: Samples For Adsorption Modelingmentioning

confidence: 99%

“…The environmental, toxicological, and health risks associated with Cr(VI) are closely linked to its speciation and behavior in the environment [4][5][6]. Therefore, there is a need for understanding the adsorption of Cr(VI) at the solid-soil solution interface, which is a major factor in determining its distribution [7,8].…”

Section: Introductionmentioning

confidence: 99%

Chromate adsorption on selected soil minerals: Surface complexation modeling coupled with spectroscopic investigation

Veselská

Fajgаr

Číhalová

et al. 2016

Journal of Hazardous Materials

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“…Cr-6 is able to cross cell membranes, be transformed to Cr-3, and interacts directly with DNA, causing mutations and carcinogenesis [47]. In an assessment of health risks in a population exposed to Cr, blood levels of Cr-3 were significantly higher in comparison to an unexposed population [48]. In addition, levels of DNA damage and oxidative stress were significantly increased, particularly among exposed compared to unexposed women.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to metals and risk of meningioma: a multinational case-control study

et al. 2016

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The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study.INTEROCC is a seven-country population-based case-control study including 1,906 adult meningioma cases and 5,565 population controls. Incident cases were recruited between 2000 and 2004. A detailed occupational history was completed and job titles were coded into standard international occupational classifications. Estimates of mean workday exposure to individual metals and to welding fumes were assigned based on a job-exposure-matrix. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression.Although more controls than cases were ever exposed to metals (14% vs. 11%, respectively), cases had higher median cumulative exposure levels. The ORs for ever vs. never exposure to any metal and to individual metals were mostly greater than 1.0, with the strongest association for exposure to iron (OR=1.26, 95%CI 1.0-1.58). In women, an increased OR of 1.70 (95%CI 1.0-2.89) was seen for ever vs never exposure to iron (OR in men 1.19 (95% CI 0.91-1.54), with positive trends in relation with both cumulative and duration of exposure. These results remained after consideration of other occupational metal or chemical co-exposures.In conclusion, an apparent positive association between occupational exposure to iron and meningioma risk was observed, particularly among women. Considering the fact that meningioma is a hormone dependent tumor, the hypothesis that an interaction between iron and estrogen metabolism may be a potential mechanism for a carcinogenic effect of iron should be further investigated.6

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“…Cr(VI) primarily enters into hepatocytes via non-specific ion channels and undergoes a reductive metabolism to stable trivalent species Cr(III)[14]. The reduction of Cr(VI) to Cr(III) is accomplished by the generation of reactive oxygen species (ROS) and caused oxidative damage and DNA mutants to hepatocytes [15,16]. In our study, L-02 hepatocytes were treated with Cr(VI) of different concentrations (0-128μM) for 24h and MTT assay was conducted to evaluate cell viability.…”

Section: Discussionmentioning

confidence: 99%

Desipramine Ameliorates Cr(VI)-Induced Hepatocellular Apoptosis via the Inhibition of Ceramide Channel Formation and Mitochondrial PTP Opening

Luo¹,

Xie²,

Wang³

et al. 2014

Cell Physiol Biochem

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Background: Hexavalent chromium (Cr(VI)) is a common environmental pollutant. Cr(VI) exposure can lead to severe damage in the liver, but the preventive measures to diminish Cr(VI)-induced hepatotoxicity need further study. Acid sphingomyelinase (ASMase) is responsible for the production of ceramide via the hydrolysis of sphingomyelin. The present study was designed to investigate effects of desipramine (DES), as an ASMase inhibitor, on Cr(VI)-induced hepatotoxicity. Methods: L-02 hepatocytes were incubated with different concentrations of Cr(VI) for 24h, and ASMase activities and ceramide levels were measured. Moreover, the study investigated the role of DES played in ASMase activities and ceramide levels. Finally, effects of DES on mRNA and protein expressions of the components of mitochondrial permeability transition pore (PTP) and PTP opening were detected. Results: The ASMase activities and ceramide contents increased in L-02 hepatocytes treated with Cr(VI). The results demonstrated that apoptosis rates, ASMase activities and ceramide content decreased in groups treated with the combination of DES and Cr(VI) compared to Cr(VI) groups. Furthermore, DES inhibited Cr(VI)-induced mitochondrial PTP opening by intervening the mRNA and protein expressions of the components of mitochondrial PTP. Conclusions: DES may exert protective effects on Cr(VI)-induced hepatocellular apoptosis probably by inhibiting ceramide channel formation and mitochondrial PTP opening.

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Assessment of health risks with reference to oxidative stress and DNA damage in chromium exposed population

Cited by 50 publications

References 38 publications

Chromate adsorption on selected soil minerals: Surface complexation modeling coupled with spectroscopic investigation

Chromate adsorption on selected soil minerals: Surface complexation modeling coupled with spectroscopic investigation

Occupational exposure to metals and risk of meningioma: a multinational case-control study

Desipramine Ameliorates Cr(VI)-Induced Hepatocellular Apoptosis via the Inhibition of Ceramide Channel Formation and Mitochondrial PTP Opening

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