Assessment of heat shock and laboratory virus challenges to selectively breed for ostreid herpesvirus 1 (OsHV-1) resistance in the Pacific oyster, Crassostrea gigas

Camara, Mark D.; Yen, Seiha; Kaspar, Heinrich F.; Kesarcodi-Watson, Aditya; King, Nathan; Jeffs, Andrew; Tremblay, Louis A.

doi:10.1016/j.aquaculture.2016.11.031

Cited by 49 publications

(44 citation statements)

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“…This suggests that the variation in family-level mortality is likely to be genetic, and the absence of mortality in the control group suggests that the challenge group mortality is due to OsHV-1 (Table S2). Moderate levels of heritability of OsHV-1 resistance were observed in this study (0.25-0.37), which is similar to was has been described in previous studies (D egremont et al 2015b;Az ema et al 2017;Camara et al 2017), and higher than shown in our previous study in a different population with lower overall mortality rate (Gutierrez et al 2018a). Heritability estimates were higher when using the genomic relationship matrix compared with estimates obtained using the pedigree-based relationship matrix.…”

Section: Disease Challenge and Heritability Of Oshv-1 Resistancesupporting

confidence: 92%

“…This causes periodic mass mortality in farms worldwide and has been mainly attributed to a specific variant of the ostreid herpesvirus (OsHV‐1; Segarra et al ), amongst other factors (Malham et al ; Petton et al ; de Lorgeril et al ). Selective breeding to improve resistance to OsHV‐1 may have potential as a prevention strategy, and there is significant additive genetic variation in survival during OsHV‐1 infection, with estimated heritability values ranging from 0.12 to 0.63 (Dégremont et al ; Azéma et al ; Camara et al ; Gutierrez et al ). However, QTL and GWAS approaches to investigating the genetic architecture of host resistance to the virus have suggested that the trait may be polygenic (Sauvage et al ; Gutierrez et al ).…”

Section: Introductionmentioning

confidence: 99%

“…Substantial efforts have been made to establish selective breeding programmes for Pacific oyster, with OsHV‐1 resistance as a primary target trait (Dégremont et al ; Camara & Symonds ; Dégremont et al ). An encouraging response to selection for resistance has been observed in Pacific oyster spat after four generations of mass selection (Dégremont et al ), whereas family‐based selection breeding programmes have shown encouraging results after a few generations (Camara et al ). Given that Pacific oysters account for 98% of global oyster production, which was estimated at approximately 0.6 million tons in 2016 (FAO, ), this pathogen is a significant problem for global aquaculture.…”

Section: Introductionmentioning

confidence: 99%

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Potential of genomic selection for improvement of resistance to ostreid herpesvirus in Pacific oyster (Crassostrea gigas)

et al. 2020

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Summary In genomic selection (GS), genome‐wide SNP markers are used to generate genomic estimated breeding values for selection candidates. The application of GS in shellfish looks promising and has the potential to help in dealing with one of the main issues currently affecting Pacific oyster production worldwide, which is the ‘summer mortality syndrome’. This causes periodic mass mortality in farms worldwide and has mainly been attributed to a specific variant of the ostreid herpesvirus (OsHV‐1). In the current study, we evaluated the potential of genomic selection for host resistance to OsHV‐1 in Pacific oysters, and compared it with pedigree‐based approaches. An OsHV‐1 disease challenge was performed using an immersion‐based virus exposure treatment for oysters for 7 days. A total of 768 samples were genotyped using the medium‐density SNP array for oysters. A GWAS was performed for the survival trait using a GBLUP approach in blupf90 software. Heritability ranged from 0.25 ± 0.05 to 0.37 ± 0.05 (mean ± SE) based on pedigree and genomic information respectively. Genomic prediction was more accurate than pedigree prediction, and SNP density reduction had little impact on prediction accuracy until marker densities dropped below approximately 500 SNPs. This demonstrates the potential for GS in Pacific oyster breeding programmes, and importantly, demonstrates that a low number of SNPs might suffice to obtain accurate genomic estimated breeding values, thus potentially making the implementation of GS more cost effective.

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Section: Disease Challenge and Heritability Of Oshv-1 Resistancesupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potential of genomic selection for improvement of resistance to ostreid herpesvirus in Pacific oyster (Crassostrea gigas)

et al. 2020

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“…These events cause periodic mass mortality in farms worldwide and have been mainly attributed to a specific variant of the ostreid herpesvirus (OsHV-1-μvar) (Segarra et al 2010), amongst other factors (de Lorgeril et al 2018; Petton et al 2015; Malham et al 2009). Selective breeding to improve resistance to OsHV-1 may have potential as a prevention strategy, and there is significant additive genetic variation in survival during OsHV-1 infection, with estimated heritability values ranging from 0.12 to 0.63 (Azéma et al 2017; Camara et al 2017; Dégremont et al 2015b; Gutierrez et al 2018a). However, QTL and GWAS approaches to investigate the genetic architecture of host resistance to the virus have suggested that the trait may be polygenic (Gutierrez et al 2018a; Sauvage et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Substantial efforts have been made to establish selective breeding programs for Pacific oyster, with OsHV-1 resistance as a primary target trait (Dégremont et al 2010; Dégremont et al 2015a; Camara and Symonds 2014). An encouraging response to selection for resistance has been observed in Pacific oyster spat after four generations of mass selection (Dégremont et al 2015c), while family based selection breeding programs have shown encouraging results after a few generations (Camara et al 2017). Given that Pacific oysters account for 98% of global oyster production, which was estimated at ∼0.6 M tons in 2016 (FAO, 2018), this pathogen is a significant problem for global aquaculture.…”

Section: Introductionmentioning

confidence: 99%

Potential of genomic selection for improvement of resistance to Ostreid Herpes virus in Pacific oyster (Crassostrea gigas)

Gutiérrez

Symonds

King

et al. 2019

Preprint

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22In genomic selection (GS), genome-wide SNP markers are used to generate genomic 23 estimated breeding values (gEBVs) for selection candidates. The application of GS in 24 shellfish looks promising and has the potential to help in dealing with one of the main 25 issues currently affecting Pacific oyster production worldwide, which is the "summer 26 mortality syndrome". This causes periodic mass mortality in farms worldwide and has 27 mainly been attributed to a specific variant of the Ostreid herpesvirus (OsHV-1-μvar). 28In the current study, we evaluated the potential of genomic selection for host 29 resistance OsHV in Pacific oysters, and compared it to pedigree-based approaches. 30An OsHV-1 disease challenge was performed using an immersion-based virus 31 exposure treatment for oysters for seven days. 768 samples were genotyped using 32 the medium density SNP array for oysters. GWAS was performed for the survival trait 33 using a GBLUP approach in BLUPF90 software. Heritability ranged from 0.25±0.05 to 34 0.37±0.05 (mean±s.e) based on pedigree and genomic information, respectively. 35Genomic prediction was more accurate than pedigree prediction, and SNP density 36 reduction had little impact on prediction accuracy until marker densities dropped below 37 ~500 SNPs. This demonstrates the potential for GS in Pacific oyster breeding 38 programs and importantly, demonstrates that a low number of SNPs might suffice to 39 obtain accurate gEBVs, thus potentially making the implementation of GS more cost 40 effective. 41 42 43 44 45 46 The use of genomic information to predict breeding values for selection candidates 47 has become commonplace in advanced breeding programmes. Genomic selection 48 (GS, proposed by Meuwissen et al. (2001), uses genome-wide markers to capture 49 genetic variation in the trait of interest, even if the trait is highly polygenic. GS involves 50 measurements of trait values and genotypes in a reference or training population, 51 training of the genomic prediction model, and then use of this model to predict 52 genomic breeding values (gEBVs) for selection candidates (Goddard and Hayes 53 2007). 54 High throughput genome-wide genotyping is a major component of genomic selection 55 programmes. SNP arrays have enabled routine genotyping, facilitating the typing of 56 many thousands of SNP markers dispersed throughout the genome of multiple 57 individuals of the target species. Accordingly, SNP arrays have been developed for 58 many important finfish aquaculture species such as Atlantic salmon, rainbow trout, 59 catfish and carp among others (Houston et al. 2014; Yáñez et al. 2016; Palti et al. 60 2015; Liu et al. 2014; Xu et al. 2014). In addition, two SNP arrays have been recently 61 developed for Pacific oyster (C. gigas); a combined-species medium density array for 62 Pacific oyster and European flat oyster (O.edulis) (Gutierrez et al. 2017) and a high 63 density array for Pacific oyster (Qi et al. 2017). Moreover, a high density linkage map 64 containing ~20K SNPs has recently been create...

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Heritability of chronic thermal tolerance and genetic correlations with growth traits in the Pacific oyster (Crassostrea gigas)

Chi,

Li,

et al. 2023

J Appl Genetics

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Assessment of heat shock and laboratory virus challenges to selectively breed for ostreid herpesvirus 1 (OsHV-1) resistance in the Pacific oyster, Crassostrea gigas

Cited by 49 publications

References 42 publications

Potential of genomic selection for improvement of resistance to ostreid herpesvirus in Pacific oyster (Crassostrea gigas)

Potential of genomic selection for improvement of resistance to ostreid herpesvirus in Pacific oyster (Crassostrea gigas)

Potential of genomic selection for improvement of resistance to Ostreid Herpes virus in Pacific oyster (Crassostrea gigas)

Heritability of chronic thermal tolerance and genetic correlations with growth traits in the Pacific oyster (Crassostrea gigas)

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