Assessment of heavy metals contamination and human health risk assessment of the commonly consumed medicinal herbs in China

Li, Haiping; Tang, Jianfeng; Chen, Tongjun; Zhu, Pingping; Sun, Dongdong; Wang, Weiyun

doi:10.1007/s11356-022-22647-z

Cited by 8 publications

(6 citation statements)

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“…At the same time, the other three, AR, IA, and BC were found to have potential risks of non-carcinogenic toxicity. These findings were similar to the reports of Odukoya et al [47], which also reported a high risk of non-carcinogenic toxicity due to the consumption of AR from Nigeria. In another study, Ghasemidehkordi et al [49] reported an HQ value of less than 1 for Hg through consumption of herbs collected from Iran, which would imply a no risk of non-carcinogenic toxicity.…”

Section: Discussionsupporting

confidence: 92%

“…Although several studies have evaluated the risk assessment of toxic metals through the consumption of herbal medicines, however only one study has performed the risk assessment of AR of the six plant materials used in this study [47], while this is the first study to carry out a risk assessment of toxic metals in the remaining five plant materials. The use of HQ and hazard indices for risk assessments of toxicants in food or edible substances is quite popular [47,48]. The data obtained from the calculation of the HQ alone implies that all six plant materials were safe for human consumption, considering their HQ values were less than 1.…”

Section: Discussionmentioning

confidence: 99%

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Metals and metalloid in medicinal plants: occurrence and risk assessment to human health

Adeyemi,

Akindele,

Salami

et al. 2024

Explor Foods Foodomics

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Aim: This study was aimed at determining the levels of trace elements in six medicinal plants of tropical origin. Methods: The levels of As, Cd, Co, Cu, Fe, Mn, Ni, Pb, and Zn in Albizia glaberrima (AG), Aristolochia ringens (AR), Brysocarpus coccineus (BC), Ipomoea asarifolia (IA), Sansevieria liberica (SL), and Telfairia occidentalis (TO) were determined using an inductively coupled plasma-mass spectrometry. The estimated dietary intakes of the metals, hazard quotients (HQ), and hazard index (HI) were calculated. Results: The highest levels of Cd, Pb, Zn, and Fe were detected in IA. BC had the highest levels of Mn and Ni while AR had the highest levels of Cu, Co, and As. However, the levels of the metals were mostly below the permissible limits in the plants. The estimated dietary weekly intakes (EWIs) were below the provisional tolerable weekly intake for each chemical element. The EWIs range values were 21.566–643.114 µg/kg per day (kg is the unit of body weight), 0.008–1.529 µg/kg per day, 0.6–7.815 µg/kg per day, 67.569–215.889 µg/kg per day, 4.305–185.451 µg/kg per day, 0.225–1.704 µg/kg per day, 1.03–10.2 µg/kg per day, 0.933–2.286 µg/kg per day, and 62.554–854.4 µg/kg per day for Cu, Cd, Pb, Zn, Mn, Co, Ni, As, and Fe, respectively. The HQ values of the elements were less than 1 except for Cu in AR (1.321). The values of lifetime cancer risks exceeded the permissible limit in all the plant materials. Conclusions: The findings from the study revealed that the consumption of TO, SL, and AG for medicinal purposes has no inherent non-carcinogenic toxicity while the consumption of AR, IA, and BC has some risks of non-carcinogenic toxic. However, the six plant materials showed inherent risks of carcinogenic events, as such their use for medicinal purposes must be cautious, maybe by reducing both the ingestion rate and the frequency of intake.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Metals and metalloid in medicinal plants: occurrence and risk assessment to human health

Adeyemi,

Akindele,

Salami

et al. 2024

Explor Foods Foodomics

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“…This is particularly important in the context of heavy metal contamination, as the safety and efficacy of these medicines could be compromised by the presence of heavy metals. Understanding the mechanisms by which medicinal plants absorb and accumulate heavy metals is vital for ensuring the safety and efficacy of herbal remedies [ 93 ]. Regular monitoring of heavy metal levels in both medicinal plants and the surrounding environment, coupled with sustainable cultivation practices, can help mitigate the risks associated with heavy metal contamination in medicinal plants [ 94 ].…”

Section: Heavy Metal Pollution Of the Environment And Concerns For Me...mentioning

confidence: 99%

“…Different parts of a medicinal plant may accumulate heavy metals to varying degrees, with roots often having higher concentrations than aerial parts. The choice of plant parts in herbal formulations influences the risk of heavy metal exposure, impacting consumers who may unknowingly ingest higher metal levels [ 54 , 93 ].…”

Section: Implications Of Heavy Metal-induced Alterations On Bioactive...mentioning

confidence: 99%

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Asiminicesei,

Fertu,

Gavrilescu

2024

Plants

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The paper provides a comprehensive examination of heavy metal stress on medicinal plants, focusing on its impact on antioxidant capacity and biosynthetic pathways critical to their therapeutic potential. It explores the complex relationship between heavy metals and the physiological and biochemical responses of medicinal plants, highlighting how metal stress disrupts biosynthetic pathways, altering concentrations of secondary metabolites. This disruption may compromise the overall quality and efficacy of medicinal plants, requiring a holistic understanding of its cumulative impacts. Furthermore, the study discusses the potential of targeted genetic editing to enhance plant resilience against heavy metal stress by manipulating genes associated with antioxidant defenses. This approach represents a promising frontier in safeguarding medicinal plants in metal-contaminated environments. Additionally, the research investigates the role of phytohormone signaling in plant adaptive mechanisms to heavy metal stress, revealing its influence on biochemical and physiological responses, thereby adding complexity to plant adaptation. The study underscores the importance of innovative technologies and global cooperation in protecting medicinal plants’ therapeutic potential and highlights the need for mitigation strategies to address heavy metal contamination effectively.

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“…Heavy metal stress tolerance has been linked to CYP71 in ginseng ( Panax quinquefolius ), CYP2E1 in Medicago sativa , CYP81D8 in Arabidopsis, CYP88A in Triticum aestivum and Pisum sativum (Chakraborty et al, 2023). When ginseng plants were exposed to heavy metals, like nickel and cadmium, CYP71 expression levels changed (Liu, Tang, et al 2022).…”

Section: Introductionmentioning

confidence: 99%

The Glycine soja cytochrome P450 gene GsCYP82C4 confers alkaline tolerance by promoting reactive oxygen species scavenging

Wu,

Fang,

et al. 2024

Physiologia Plantarum

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Recent studies have demonstrated the crucial role of Cytochrome P450 enzymes (CYPs) in the production of secondary metabolites, phytohormones and antioxidants in plants. However, their functional characterization specifically under alkaline stress remains elusive. CYP82C4 was the key gene screened from a family of wild soybean CYPs in our previous studies. The aim of this present study was to clone the Glycine soja GsCYP82C4 gene and characterize its functions in Arabidopsis and Glycine max. The results showed that the GsCYP82C4 gene displayed a high expression in different plant tissues at mature stages compared to young stages. Further, higher temporal expression of the GsCYP82C4 gene was noted at 6, 12 and 24 h time points after alkali treatment in leaves compared to roots. In addition, overexpression of GsCYP82C4 improved alkaline stress tolerance in Arabidopsis via increased root lengths and fresh biomass and strengthened the antioxidant defense system via a reduction in superoxide radicals in transgenic lines compared to wild type (WT) and atcyp82c4 mutants. Further, the expression levels of stress‐related marker genes were up‐regulated in GsCYP82C4 OX lines under alkali stress. The functional analysis of GsCYP82C4 overexpression in soybean displayed better hairy root growth, increased fresh weight, higher antioxidant enzyme activities and reduced lipid peroxidation rates in OX lines compared to the soybean WT (K599) line. In total, our study displayed positive roles of GsCYP82C4 overexpression in both Arabidopsis and Glycine max to alleviate alkaline stress via altering expression abundance of stress responsive genes, stronger roots, higher antioxidant enzyme activities as well as reduced rates of lipid peroxidation and superoxide radicals.

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Assessment of heavy metals contamination and human health risk assessment of the commonly consumed medicinal herbs in China

Cited by 8 publications

References 50 publications

Metals and metalloid in medicinal plants: occurrence and risk assessment to human health

Metals and metalloid in medicinal plants: occurrence and risk assessment to human health

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

The Glycine soja cytochrome P450 gene GsCYP82C4 confers alkaline tolerance by promoting reactive oxygen species scavenging

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