Assessment of Hemolysis in a Ventricular Assist Axial Flow Blood Pump

Gouskov, A.; Lomakin, V; Banin, Evgeny P.; Kuleshova, M

doi:10.1007/s10527-016-9627-x

Cited by 12 publications

(4 citation statements)

References 16 publications

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“…Therefore, the multiple reference frame (MRF) model was used to set the rotation area. The flow channel model was divided into three parts, which were meshed with non-structured elements [14,15]. The gradient of physical quantities in the rotating area was large, so the meshes were refined.…”

Section: Mesh Generationmentioning

confidence: 99%

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CFD-Based Flow Channel Optimization and Performance Prediction for a Conical Axial Maglev Blood Pump

Yang

Peng

Xiao

et al. 2022

Sensors

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Ventricular assist devices or total artificial hearts can be used to save patients with heart failure when there are no donors available for heart transplantation. Blood pumps are integral parts of such devices, but traditional axial flow blood pumps have several shortcomings. In particular, they cause hemolysis and thrombosis due to the mechanical contact and wear of the bearings, and they cause blood stagnation due to the separation of the front and rear guide wheel hubs and the impeller hub. By contrast, the implantable axial flow, maglev blood pump has the characteristics of no mechanical contact, no lubrication, low temperature rise, low hemolysis, and less thrombosis. Extensive studies of axial flow, maglev blood pumps have shown that these pumps can function in laminar flow, transitional flow, and turbulent flow, and the working state and performance of such pumps are determined by their support mechanisms and flow channel. Computational fluid dynamics (CFD) is an effective tool for understanding the physical and mechanical characteristics of the blood pump by accurately and effectively revealing the internal flow field, pressure–flow curve, and shear force distribution of the blood pump. In this study, magnetic levitation supports were used to reduce damages to the blood and increase the service life of the blood pump, and a conical impeller hub was used to reduce the speed, volume, and power consumption of the blood pump, thereby facilitating implantation. CFD numerical simulation was then carried out to optimize the structural parameters of the conical axial maglev blood pump, predict the hemolysis performance of the blood pump, and match the flow channel and impeller structure. An extracorporeal circulation simulation platform was designed to test whether the hydraulic characteristics of the blood pump met the physiological requirements. The results showed that the total pressure distribution in the blood pump was reasonable after optimization, with a uniform pressure gradient, and the hemolysis performance was improved.

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Section: Mesh Generationmentioning

confidence: 99%

“…structured elements [14,15]. The gradient of physical quantities in the rotating area was large, so the meshes were refined.…”

Section: Mesh Generationmentioning

confidence: 99%

CFD-Based Flow Channel Optimization and Performance Prediction for a Conical Axial Maglev Blood Pump

Yang

Peng

Xiao

et al. 2022

Sensors

View full text Add to dashboard Cite

show abstract

“…The simulation results are used to evaluate and improve devices. 11 , 12 For example, in the research and development of blood pumps, researchers use CFD methods to analyse and evaluate the flow field state and hemolysis level of different structures, to promote the optimization of the structure and performance of blood pumps. 13 , 14 , 15 , 16 However, most current studies have simplified blood into a single-phase flow liquid.…”

Section: Introductionmentioning

confidence: 99%

Enhanced discrete phase model for multiphase flow simulation of blood flow with high shear stress

Tan

Wang

2021

Science Progress

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Shear stress is often present in the blood flow within blood-contacting devices, which is the leading cause of hemolysis. However, the simulation method for blood flow with shear stress is still not perfect, especially the multiphase flow model and experimental verification. In this regard, this study proposes an enhanced discrete phase model for multiphase flow simulation of blood flow with shear stress. This simulation is based on the discrete phase model (DPM). According to the multiphase flow characteristics of blood, a virtual mass force model and a pressure gradient influence model are added to the calculation of cell particle motion. In the experimental verification, nozzle models were designed to simulate the flow with shear stress, varying the degree of shear stress through different nozzle sizes. The microscopic flow was measured by the Particle Image Velocimetry (PIV) experimental method. The comparison of the turbulence models and the verification of the simulation accuracy were carried out based on the experimental results. The result demonstrates that the simulation effect of the SST k- ω model is better than other standard turbulence models. Accuracy analysis proves that the simulation results are accurate and can capture the movement of cell-level particles in the flow with shear stress. The results of the research are conducive to obtaining accurate and comprehensive analysis results in the equipment development phase.

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“…3,4 At present, computational fluid dynamics (CFD) has gradually matured in the analysis and evaluation of hydraulic and hemolytic performance of the blood pump in its development stage. 5,6 Researchers combined CFD and experiment designs to study the state and performance of the flow fields of blood pumps with different structures, starting from details such as the gap, blade height, and blade shape. Although they have continuously optimized the performance of blood pump, 7–10 there is room for further improvement.…”

Section: Introductionmentioning

confidence: 99%

Multi-parameter analysis of the effects on hydraulic performance and hemolysis of blood pump splitter blades

Tan

Wang

2014

Advances in Mechanical Engineering

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The splitter blade can effectively optimize pump performance, but there is still insufficient research in blood pumps that cover both hydraulic and hemolysis performance. Thus, the aim of this study was to investigate the effect of key factors related to splitter blade on the performance and flow field of axial flow blood pump. In this study, the number of splitter blades, the axial length, and the circumferential offset were chosen as three objects of study. An analysis of the flow field and performance of the pump by orthogonal array design using computational fluid mechanics was carried out. A set of hydraulic and particle image velocimetry experiments of the model pumps were performed. The result showed that the pump had greater hydraulic performance without sacrificing its hemolytic performance when it had two splitter blades, the axial length ratio was 0.6, and the circumferential offset was 15°. Based on these reference data, the splitter blade may contribute to greater hydraulic performance of the pump and cause no side effect on the velocity distribution of the flow field. This finding provides an effective method for the research, development, and application of structural improvement of the axial flow blood pump.

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Assessment of Hemolysis in a Ventricular Assist Axial Flow Blood Pump

Cited by 12 publications

References 16 publications

CFD-Based Flow Channel Optimization and Performance Prediction for a Conical Axial Maglev Blood Pump

CFD-Based Flow Channel Optimization and Performance Prediction for a Conical Axial Maglev Blood Pump

Enhanced discrete phase model for multiphase flow simulation of blood flow with high shear stress

Multi-parameter analysis of the effects on hydraulic performance and hemolysis of blood pump splitter blades

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