Assessment of Hemostatic Efficacy and Osseous Wound Healing Using HemCon Dental Dressing

Azargoon, Homa; Williams, Benjamin F.; Solomon, Eric; Kessler, Harvey P.; He, Jianing; Spears, Robert

doi:10.1016/j.joen.2011.02.023

Cited by 29 publications

(20 citation statements)

References 21 publications

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“…In the ChiS-implanted groups, the newly formed bone in the marginal portion was thick, and highly matured, with abundant lacuna consisting of osteocytes. These results might be explained by previous reports that ChiS itself potently stimulated bone formation as a scaffold, rather than a carrier for rhBMP-9, especially at the peripheral regions of the defects [30][31][32] . It is plausible that ChiS was effective only at the initial stage of bone healing and did not maintain a constant concentration of rhBMP-9 when used as a carrier.…”

Section: Discussionmentioning

confidence: 66%

Bone healing capabilities of recombinant human bone morphogenetic protein-9 (rhBMP-9) with a chitosan or collagen carrier in rat calvarial defects

et al. 2016

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The aim of this study was to examine the effects of recombinant human BMP-9 (rhBMP-9) with chitosan sponge (ChiS) or absorbable collagen sponge (ACS) on bone formation in rat calvarial defects. The defects were treated by one of the following implantations: ChiS, rhBMP-9/ChiS, ACS, rhBMP-9/ACS and no implantation. The animals were euthanized at 8 weeks for histological evaluation. The percentage of defect closure (DC) in the rhBMP-9/ACS group was significantly greater than that in the ACS group. The rhBMP-9/ ACS group demonstrated the highest level of DC among all the groups. The newly formed bone area (NBA) and NBA/total area in the ChiS-implanted groups and in the rhBMP-9/ACS group were significantly greater compared with those in the ACS group. It can be concluded that rhBMP-9/ACS has a potential to induce bone formation in rat calvarial defects. Further studies are required to elucidate the mechanism of bone formation induced by rhBMP-9.

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Section: Discussionmentioning

confidence: 66%

Bone healing capabilities of recombinant human bone morphogenetic protein-9 (rhBMP-9) with a chitosan or collagen carrier in rat calvarial defects

et al. 2016

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“…They show that HemCon is a new generation haemostatic agent which facilitates early haemostasis of extraction wounds, along with improved healing and reduces postoperative pain. 25 The use of HDD eliminates or minimises the risk of thromboembolism by allowing the patient to continue his/her antiplatelet medication regimens; however, the haemostatic properties of the HDD do not obviate the need for thorough pre-and postoperative evaluation and management of a patient's INR status.…”

Section: Resultsmentioning

confidence: 99%

“…23,24 In an animal study, Azargoon et al found HDD to be as efficacious ferric sulfate in haemostasis and wound healing. 25 The self-adhesive nature of HDD is caused by the electrostatic attraction of RBC to the HemCon material. As the RBCs bind to the HDD surface, it forms a dense viscous mass that provides adhesion, and also adapts to the alveolar bone's irregularities under digital pressure, thereby providing frictional locking with the bony socket.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Hemcon Dental Dressing Versus Conventional Method of Haemostasis in 40 Patients on Oral Antiplatelet Drugs

Kale¹,

Singh²,

Kotrashetti³

et al. 2012

SQUMJ

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abstract:Objectives: The purpose of the study was to evaluate the effectiveness of the HemCon Dental Dressing (HDD) in controlling post extraction bleeding and to ascertain its role in healing of extraction wounds, as compared to control. Methods: The 40 participants in the study were all receiving oral antiplatelet therapy (OAT). A total of 80 extractions were conducted without altering the patients' drug therapy. The extraction sites were divided into 2 groups: one group received a HDD, and the control group where the conventional method of pressure pack with sterile gauze under biting pressure (followed by suturing if required) was used to achieve haemostasis. Results: All HemCon treated sites achieved haemostasis sooner (mean = 53 seconds) than the control sites (mean = 918 seconds) which was statistically significant (P <0.001). Postoperative pain in the HDD group (1.74) was also significantly lower than in the control group (5.26) (P <0.001). Approximately 72.5% of HDD-treated sites showed significantly better postoperative healing when compared to the control site (P <0.001). Conclusion: HDD proved to be an excellent haemostatic agent that significantly shortened the bleeding time following dental extraction in patients on OAT. Additionally, HDD offered significantly improved post-operative healing of the extraction socket and less postoperative pain. Keywords

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“…There are different haemostatic techniques or materials to reduce bleeding. Some of these proposed agents to control bleeding in apical surgery are: bone wax (6-8), cellulose membranes (9-11), gelatine sponges (10,11), collagen agents (9,11), thrombin (10-12), chitosan (9,13), epinephrine (11,14,15), ferric sulphate (16-21), calcium sulphate (16) and aluminium chloride (14,15,18-21). Different articles have addressed haemostatic agents for apical surgery, but to date there isn’t any specific systematic review on this topic.…”

Section: Introductionmentioning

confidence: 99%

Haemostatic agents in apical surgery. A systematic review

Clé-Ovejero¹,

Valmaseda‐Castellón²

2016

Med Oral

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BackgroundBlood presence in apical surgery can prevent the correct vision of the surgical field, change the physical properties of filling materials and reduce their sealing ability. ObjetiveTo describe which are the most effective and safest haemostatic agents to control bleeding in patients undergoing apical surgery.Material and MethodsTWe carried out a systematic review, using Medline and Cochrane Library databases, of human clinical studies published in the last 10 years.ResultsThe agents that proved more effective in bleeding control were calcium sulphate (100%) and collagen plus epinephrine (92.9%) followed by ferric sulphate (60%), gauze packing (30%) and collagen (16.7%). When using aluminium chloride (Expasyl®), over 90% of the apical lesions improved, but this agent seemed to increase swelling. Epinephrine with collagen did not significantly raise either blood pressure or heart rate.ConclusionsDespite the use of several haemostatic materials in apical surgery, there is little evidence on their effectiveness and safety. The most effective haemostatic agents were calcium sulphate and epinephrine plus collagen. Epinephrine plus collagen did not seem to significantly raise blood pressure or heart rate during surgery. Aluminium chloride did not increase postoperative pain but could slightly increase postoperative swelling. Randomized clinical trials are needed to assess the haemostatic effectiveness and adverse effects of haemostatic materials in apical surgery. Key words:Haemostasis, apical surgery.

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Assessment of Hemostatic Efficacy and Osseous Wound Healing Using HemCon Dental Dressing

Cited by 29 publications

References 21 publications

Bone healing capabilities of recombinant human bone morphogenetic protein-9 (rhBMP-9) with a chitosan or collagen carrier in rat calvarial defects

Bone healing capabilities of recombinant human bone morphogenetic protein-9 (rhBMP-9) with a chitosan or collagen carrier in rat calvarial defects

Effectiveness of Hemcon Dental Dressing Versus Conventional Method of Haemostasis in 40 Patients on Oral Antiplatelet Drugs

Haemostatic agents in apical surgery. A systematic review

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