Assessment of hepatic steatosis based on virtual non-contrast computed tomography: Initial experiences with a photon counting scanner approved for clinical use

Woeltjen, Matthias Michael; Saeed, Saher; Michael, Arwed Elias; Boriesosdick, Jan; Borggrefe, Jan; Kroeger, Jan Robert

doi:10.1016/j.ejrad.2022.110185

Cited by 24 publications

(19 citation statements)

References 38 publications

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“…Other studies tended to show larger discrepancies between VNC and TNC, 75 and VNC images from PCD-CT resulted in overestimation and underestimation of the true unenhanced attenuation of adrenal adenomas. 76 When investigating possible clinical applications, VNC images from PCD-CT were found to be reliable for the assessment of hepatic steatosis 77 and for emphysema quantification from contrast-enhanced lung scans. 78 The combination of high temporal and spatial resolution with spectral data acquisition enables novel applications for cardiovascular CT. For example, material decomposition into iodine and calcium can be used to remove the iodine from cCTAs, leaving only the calcium in the coronary arteries (PURE Calcium, Siemens Healthcare).…”

Section: Spectral Imaging Capabilitiesmentioning

confidence: 99%

Technical Basics and Clinical Benefits of Photon-Counting CT

Flohr

Schmidt

2023

Invest Radiol

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Novel photon-counting detector CT (PCD-CT) has the potential to address the limitations of previous CT systems, such as insufficient spatial resolution, limited accuracy in detecting small low-contrast structures, or missing routine availability of spectral information. In this review article, we explain the basic principles and potential clinical benefits of PCD-CT, with a focus on recent literature that has grown rapidly since the commercial introduction of a clinically approved PCD-CT.

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Section: Spectral Imaging Capabilitiesmentioning

confidence: 99%

Technical Basics and Clinical Benefits of Photon-Counting CT

Flohr

Schmidt

2023

Invest Radiol

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“…Sartoretti et al provide further information on these novel QIR algorithms [ 18 ]. Both preclinical studies using PCCT prototypes and early studies with the first PCCT scanner that is approved for clinical use show promising results [ 15 , 16 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Low-Dose High-Resolution Photon-Counting CT of the Lung: Radiation Dose and Image Quality in the Clinical Routine

et al. 2022

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This study aims to investigate the qualitative and quantitative image quality of low-dose high-resolution (LD-HR) lung CT scans acquired with the first clinical approved photon counting CT (PCCT) scanner. Furthermore, the radiation dose used by the PCCT is compared to a conventional CT scanner with an energy-integrating detector system (EID-CT). Twenty-nine patients who underwent a LD-HR chest CT scan with dual-source PCCT and had previously undergone a LD-HR chest CT with a standard EID-CT scanner were retrospectively included in this study. Images of the whole lung as well as enlarged image sections displaying a specific finding (lesion) were evaluated in terms of overall image quality, image sharpness and image noise by three senior radiologists using a 5-point Likert scale. The PCCT images were reconstructed with and without a quantum iterative reconstruction algorithm (PCCT QIR+/−). Noise and signal-to-noise (SNR) were measured and the effective radiation dose was calculated. Overall, image quality and image sharpness were rated best in PCCT (QIR+) images. A significant difference was seen particularly in image sections of PCCT (QIR+) images compared to EID-CT images (p < 0.005). Image noise of PCCT (QIR+) images was significantly lower compared to EID-CT images in image sections (p = 0.005). In contrast, noise was lowest on EID-CT images (p < 0.001). The PCCT used significantly less radiation dose compared to the EID-CT (p < 0.001). In conclusion, LD-HR PCCT scans of the lung provide better image quality while using significantly less radiation dose compared to EID-CT scans.

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“…55 Single-energy and DECT have been shown to have good accuracy in fat quantification for higher fat fractions, and radiomics analysis can distinguish normal liver tissue from steatotic tissue. 56 Photon-counting CT has been shown to be accurate for index-based liver fat estimation from VNC images 57 but can also perform 3-material decomposition on all abdominal imaging and has the potential to improve opportunistic screening for hepatic steatosis (Fig. 4).…”

Section: Liver Fat Quantificationmentioning

confidence: 99%

Exploiting the Potential of Photon-Counting CT in Abdominal Imaging

Schwartz¹,

Samei

Marin³

2023

Invest Radiol

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Photon-counting computed tomography (PCCT) imaging uses a new detector technology to provide added information beyond what can already be obtained with current CT and MR technologies. This review provides an overview of PCCT of the abdomen and focuses specifically on applications that benefit the most from this new imaging technique. We describe the requirements for a successful abdominal PCCT acquisition and the challenges for clinical translation. The review highlights work done within the last year with an emphasis on new protocols that have been tested in clinical practice. Applications of PCCT include imaging of cystic lesions, sources of bleeding, and cancers. Photon-counting CT is positioned to move beyond detection of disease to better quantitative staging of disease and measurement of treatment response.

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Assessment of hepatic steatosis based on virtual non-contrast computed tomography: Initial experiences with a photon counting scanner approved for clinical use

Cited by 24 publications

References 38 publications

Technical Basics and Clinical Benefits of Photon-Counting CT

Technical Basics and Clinical Benefits of Photon-Counting CT

Low-Dose High-Resolution Photon-Counting CT of the Lung: Radiation Dose and Image Quality in the Clinical Routine

Exploiting the Potential of Photon-Counting CT in Abdominal Imaging

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