Assessment of herb field mouse (Sylvaemus uralensis) migration in the area of the east urals radioactive trace using measurements of bone-seeking 90Sr

Shishkina, E.A.; Starichenko, V.I.; Valeeva, E. R.; Lyubashevsky, N.M.; Modorov, M. V.

doi:10.1016/j.jenvrad.2021.106663

Cited by 2 publications

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“…Internal BM exposure due to 90 Sr incorporation can be based on the information about skeleton contamination (Starichenko 2004;Starichenko et al 2014). In Shishkina et al (2021a) the data on 90 Sr skeleton contamination of herb field mouse (Sylvaemus uralensis) obtained during long-term (2003 -2012 years) study were summarized. There were 3 sampling areas selected for the purposes of the study with the following initial (just after the explosion) 90 Sr deposition density: (1) 3.7-37 MBq m -2 ; (2) 74-3,700 kBq m -2 and (3) 37 kBq m -2 .…”

Section: Dosimetry Of Rodents Exposed At the East Urals Radioactive T...mentioning

confidence: 99%

“…The data on subadultus (non-breeding underyearlings) can be roughly associated with the data on growing individuals; two groups of breeding individuals (underyealing and wintering) can be associated with adults in the current study. Table 6 presents the group-average data on 90 Sr activity concentration in the murine bones (per wet weight) estimated according to Shishkina et al (2021a) and the corresponding BM dose rates. The 90%CI for the dose rate reflects the overall individual variability of the activity concentrations and dose factors.…”

Section: Dosimetry Of Rodents Exposed At the East Urals Radioactive T...mentioning

confidence: 99%

“…In other words, in case of bone-seeking beta emitters, doses to the bone calculated assuming the uniform radionuclide distribution in homogenous bone medium don't reflect bone marrow exposure and overestimate considerably the body-average dose, which leads to excessive conservatism. Thus, the problem of the discrepancy between the observed radioecological effects and the accumulated doses at the EURT (that caused protracted scientific discussions) (Shishkina et al 2021a) may be solved with the help of the adequate dosimetry. This example indicates the importance of taking bone microarchitecture into account, as, for example, it was implemented in SPDS.…”

Section: Dosimetry Of Rodents Exposed At the East Urals Radioactive T...mentioning

confidence: 99%

“…Long-lived 90 Sr (T1/2~29 years) may irradiate the active bone marrow over a long period of time. Adverse health effects of chronic radiation exposure for small mammals are highly debated topic (Fesenko 2019;Dahl et al 2021;Shishkina et al 2021a).…”

Section: Introductionmentioning

confidence: 99%

“…The group-average data on90 Sr activity concentration (A) in the murine bones (according toShishkina et al 2021a) and corresponding dose rates in bone marrow due to internal exposure to90 Sr. The 90%CI for the dose rate reflects the overall individual variability of the activity concentrations and dose factors…”

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Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Shishkina

Shuiskaya

Sharagin

2022

Radiat Environ Biophys

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Studies of radiobiological effects in murine rodents exposed to internal radiation in the wild or in laboratory experiments require a dosimetric support. The main problem of bone marrow (BM) dosimetry for boneseeking β-emitters is dosimetric modeling due to the fact that the bone is a heterogeneous structure with complex microarchitecture. To date, there are several approaches to calculating the absorbed dose in BM, which mostly use rough geometric approximations. Recently, in the framework of studies of people exposed to 90 Sr in the Urals, a new approach (SPSD) has been developed. The aim of current study was to pilot test the possibility of extension of the SPSD-approach elaborated for humans to mice. The computational phantoms of femur bones of laboratory animals (C57BL/6, C57BL/6J, BALB/c, BALB/cJ) aged 5-8 weeks (growing) and >8 weeks (adults) were created. The dose factors to convert the 89,90 Sr activity concentrations in a bone tissue into units of the dose rate absorbed in the bone marrow were estimated as follows: DFSr-90(BMTBV+CBV) is equal to 1.75±0.42 and 2.57±0.93 (μGy day -1 ) per (Bq g -1 ) for growing and adults, respectively; DFSr-89(BMTBV+CBV) is equal to 1.08±0.27 and 1.66±0.67 (μGy day -1 ) per (Bq g -1 ) for growing and adults, respectively. These results are about 2.5 times lower than skeleton-average DF, calculated assuming the homogenous bone, where source and target coincide. The study demonstrates the possibility of application of the SPSD-approach elaborated for humans to non-human mammals.

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Section: Dosimetry Of Rodents Exposed At the East Urals Radioactive T...mentioning

confidence: 99%

Section: Dosimetry Of Rodents Exposed At the East Urals Radioactive T...mentioning

confidence: 99%

Section: Dosimetry Of Rodents Exposed At the East Urals Radioactive T...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Shishkina

Shuiskaya

Sharagin

2022

Radiat Environ Biophys

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Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Shishkina

Shuiskaya

Sharagin

2022

Preprint

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Studies of radiobiological effects in murine rodents exposed to internal radiation in the wild or in laboratory experiments require a dosimetric support. The main problem of bone marrow (BM) dosimetry for bone-seeking β-emitters is dosimetric modeling due to the fact that the bone is a heterogeneous structure with complex microarchitecture. To date, there are several approaches to calculating the absorbed dose in BM, which mostly use rough geometric approximations. Recently, in the framework of studies of people exposed to 90Sr in the Urals, a new approach (SPSD) has been developed. The aim of current study was to pilot test the possibility of extension of the SPSD-approach elaborated for humans to mice. The computational phantoms of femur bones of laboratory animals (C57BL/6, C57BL/6J, BALB/c, BALB/cJ) aged 5–8 weeks (growing) and > 8 weeks (adults) were created. The dose factors to convert the 89,90Sr activity concentrations in a bone tissue into units of the dose rate absorbed in the bone marrow were estimated as follows: DFSr−90(BM←TBV + CBV) is equal to 1.75 ± 0.42 and 2.57 ± 0.93 (µGy day− 1) per (Bq g− 1) for growing and adults, respectively; DFSr−89(BM←TBV + CBV) is equal to 1.08 ± 0.27 and 1.66 ± 0.67 (µGy day− 1) per (Bq g− 1) for growing and adults, respectively. These results are about 2.5 times lower than skeleton-average DF, calculated assuming the homogenous bone, where source and target coincide. The study demonstrates the possibility of application of the SPSD-approach elaborated for humans to non-human mammals.

show abstract

Assessment of herb field mouse (Sylvaemus uralensis) migration in the area of the east urals radioactive trace using measurements of bone-seeking 90Sr

Cited by 2 publications

References 0 publications

Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

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