Assessment of HHV-6 And HHV-7 in Patients After Kidney Transplantation

Abstract

Human herpesviruses HHV-6 and HHV-7 reactivation in transplantation is associated with indirect immunomodulatory effects, such as cytomegalovirus (CMV) disease, increased opportunistic infections, graft dysfunction and acute rejection (AR). In this study, we analysed the clinical and immunological outcomes in renal transplant recipients (RTR) with active HHV-6 and HHV-7 infection. Between January 2007 and December 2007, clinical, virological and immunological tests were carried out in 46 RTR. The patients were divided into three groups: with active HHV-6 infection; with active HHV-7 infection; and without infection (control). The mean follow-up was 14 ± 2.5 months. At three months after renal transplantation (RT), active CMV infection was present in 12 (26%); HHV-6 in four (8.6%); and HHV-7 in nine (19.5%) of RTR. Active ß-herpesviruses infection was not associated with more frequent AR and worsening of graft function in recipients at different times after RT. The lymphocyte subsets (CD3+; CD4+ and CD8+ cell count) were considerably lower in RTR before RT. At 3 months after RT CD19+ and CD25+ cell counts were significantly increased in the HHV-7 group compared with the control group (P < 0.05). Significant differences were not found in clinical and immunological outcomes between patients with active ß-herpesviruses infection and those without active ß-herpesviruses infection.

Human Herpes Virus 6 and 7 Co-infections with Cytomegalovirus in patients with kidney transplantation

“…The sero-prevalence rates of CMV and HHV-7 in RTR were (97.7%) and (32%) respectively. | P a g e Finally Table (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) involves correlations among the anti-CMV and HHV-7 IgG antibodies titers and viral loads of the three beta herpes viruses. Human CMV viral load (VL) is significantly increasing, and is significantl y correlated with the VL of both roseolaviruses after three months of follow up.…”

“…A growing body of evidence suggests that the major impact of HHV-6 and HHV-7 reactivation in transplantation is related to indirect immunomodulatory effects, such as their association with CMV disease, increased opportunistic infections, graft dysfunction and rejection (6,7) . Furthermore, other studies indicated that in kidney recipients with rejection, HHV-7 was more frequently associated with rejection episodes (32) .…”

“…Without appropriate prophylaxis, about 80% of solid organ transplant recipients may experience CMV infection (5) . http://doi.org/10.36295/ASRO.2021.24531 DOI: 400 | P a g e Human herpesviruses HHV-6 and HHV-7 reactivation in transplantation is associated with indirect immunomodulatory effects, such as cytomegalovirus (CMV) disease, increased opportunistic infections, graft dysfunction, and acute rejection (6) . The kinetics of the activation of these viruses during the post-transplantation period suggest that HHV-7 may act as a co-factor for HH-6 and CMV reactivation, while both HHV-6 and HHV-7 may act as co-factors in the pathogenesis of CMV disease and acute rejection (7,8) .…”