Assessment of homocysteine, neopterin and nitric oxide levels in Behcet's disease

Özkan, Yeşim; Yardım-Akaydin, Sevgi; Sepici, Aylin; Engin, Başak; Sepici, Vesile; Şimşek, Bolkan

doi:10.1515/cclm.2007.018

Cited by 40 publications

(28 citation statements)

References 41 publications

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“…Gunduz et al (29) reported no significant change in plasma NO levels in RAU and Behcet's disease. Ozkan et al (30) reported no significant difference between the serum NO levels in RAU and healthy patients, but reported a significant difference among patients with Behcet's disease.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers

Avcı

Akarslan

Erten

et al. 2014

Braz J Med Biol Res

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Recurrent aphthous ulcer (RAU) is an inflammatory condition of the oral mucosa characterized by painful, well-circumscribed, single or multiple round or ovoid ulcerations. The exact etiologic factor(s) of these ulcerations are not yet understood. The objective of this study was to evaluate inflammatory processes and free radical metabolism of 25 patients with RAUs compared to 25 healthy controls. The levels of malondialdehyde (MDA) and glutathione (GSH) were determined by high-performance liquid chromatography. Tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), IL-10, and IL-12 were determined by ELISA. Nitric oxide (NO), myeloperoxidase (MPO), total antioxidant status (TAS), and total oxidant status (TOS) levels were measured spectroscopically in serum. The levels of MDA, GSH, TNF-α, IL-2, IL-12, MPO, and TOS, and oxidative stress index (OSI) were higher, and the levels of NO, IL-10, and TAS were lower in patients with RAU than in controls. Statistical analysis showed that GSH, TNF-α, IL-2, IL-10, and OSI differed significantly in patients with RAU compared to controls. These parameters have important roles in oxidant/antioxidant defense.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers

Avcı

Akarslan

Erten

et al. 2014

Braz J Med Biol Res

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“…Homocysteine was reported to be higher in patients with BS, particularly in patients with active disease status compared to healthy controls. 16,17 Elevated Hcy has also been reported to be associated with thrombosis in vascular BS in several studies. [18][19][20][21] Cerebral venous sinus thrombosis frequently co-occurs with peripheral venous vascular events such as deep venous thrombosis and pulmonary vascular disease; therefore, serum Hcy levels are expected to be high in vascular NBS.…”

Section: Discussionmentioning

confidence: 99%

Serum Vitamin B12, Homocysteine and Methylmalonic Acid Levels in Patients With Parenchymal Neuro-Behçet’s Syndrome

et al. 2017

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Objectives: This study aims to investigate the role of serum levels of vitamin B12 (VitB12), homocysteine (Hcy), and methylmalonic acid (MMA) in the development of parenchymal neuro-Behçet's syndrome (NBS) and to compare them with healthy controls and Behçet's syndrome (BS) patients without NBS. Patients and methods: Serum VitB12, Hcy, and MMA were measured using enzyme-linked immunosorbent assay in 64 patients (36 males, 28 females; mean age 36±8.3 years; range 20 to 56 years) who met the criteria of the International Study Group for Behçet's Disease and 30 matched healthy controls (17 males, 13 females; mean age 35.76±9.6 years; range 20 to 50 years). The study participants were grouped as BS patients with NBS, BS patients without NBS, and healthy controls. Results: There was no significant difference between the groups regarding serum VitB12, Hcy, and MMA levels (p>0.05). Serum VitB12 levels were below the lower limit and serum Hcy levels were above the upper limit in all participants. MMA levels were normal in all participants. There was no correlation between the serum levels of VitB12, Hcy, and MMA and disease activity (p>0.05). Conclusion:The results of this study suggest that there is no significant association between VitB12 deficiency and parenchymal NBS. Further studies are needed to investigate the underlying mechanisms of the variable effects of VitB12 deficiency on different clinical manifestations of BS.

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“…77 In another recent study, hyperhomocysteinemia was confirmed as a definite finding in BD patients compared to controls. 96 Other researchers have found no association between venous involvement and hyperhomo-cysteinemia, thought not to be an independent factor for vascular involvement. 97 Aksu 93 hypothesized that homocysteine had a deleterious effect on endothelial cells, causing endothelial cell damage, smooth muscle cell proliferation, and increased oxidative stress.…”

Section: Homocysteinementioning

confidence: 95%

“…Homocysteine activates T cells and increases the interaction of monocytes and T cells with endothelial cells. 96 From these studies it is obvious that the exact mechanism by which hyperhomocysteinemia is related to vascular disease and venous thrombosis remains to be clarified by further investigation.…”

Section: Homocysteinementioning

confidence: 99%

Behçet’s disease: an update on pathogenesis, diagnosis and management of vascular involvement

Kaklamanis

Calamia

2010

Rheumatol Rep

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The objective of this review is to summarize reports of the prevalence, clinical presentation, diagnostic methodology and treatment of vasculitic manifestations of Behçet’s disease (BD). We performed a literature search on vasculitis in BD. Articles were selected which provided insight into the pathogenesis and clinical aspects of vasculitis. Vasculitis underlies many of the clinical features of BD. Small vessel vasculitis is often found in the pathology of the mucocutaneous manifestations of BD. Large vessel vasculitis has been reported in 15-40% of BD patients. Ultrasound, angiography and tomography are applied to confirm the diagnosis when venous involvement is suspected. Endothelial dysfunction plays a role in the pathogenesis of disease. Peripheral arterial involvement in BD occurs in the form of arterial occlusion or aneurysms. Pulmonary arterial involvement is often life-threatening. The cause of cardiac vascular involvement requires an aggressive diagnostic approach. Corticosteroids and immunosuppressive agents have been used successfully in the early stage of large vessel disease and should be used as an adjunct to surgery. An increasing amount of data is available regarding the role of anti-tumor necrosis factor (TNF) agents for the treatment of BD. Anticoagulant therapy may be hazardous in patients with aneurysmal dilatation of the pulmonary vascular tree and is not effective in the treatment of venous thrombosis. Inflammation of small and large vessels is very frequent in BD. Both arteries and veins may be involved. Early recognition and appropriate management of large vessel vasculitis in BD is essential to reduce associated morbidity and mortality

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Assessment of homocysteine, neopterin and nitric oxide levels in Behcet's disease

Abstract: In contrast to recurrent aphthous stomatitis, there is a higher prevalence of hyperhomocysteinemia in Behcet's disease. Homocysteine may have deleterious effects on the pathology of Behcet's disease by decreasing nitric oxide levels and interfering with the immune system.

Cited by 40 publications

References 41 publications

Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers

Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers

Serum Vitamin B12, Homocysteine and Methylmalonic Acid Levels in Patients With Parenchymal Neuro-Behçet’s Syndrome

Behçet’s disease: an update on pathogenesis, diagnosis and management of vascular involvement

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