Assessment of hypolipidemic and anti‐inflammatory properties of walnut (<i>Juglans regia</i>) seed coat extract and modulates some metabolic enzymes activity in triton <scp>WR‐1339‐induced</scp> hyperlipidemia in rat kidney, liver, and heart

Palabıyık, Esra; Sulumer, Ayşe Nurseli; Uguz, Handan; Avcı, Bahri; Aşkın, Seda; Aşkın, Hakan; Demir, Yeliz

doi:10.1002/jmr.3004

Cited by 37 publications

(22 citation statements)

References 104 publications

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“…Integrating the changes discovered in the metabolomic and the proteomic profiles of the liver in response to mitochondrial transfer therapy (similar to the report testing the interaction of lipids with the activity of enzyme-protein in the liver [ 46 ]) revealed alterations in amino acid metabolism, glutathione metabolism, glucose metabolism, sphingolipid metabolism, and acylcarnitines (within mitochondria, as the acylcarnitines are derivatives of long-chain fatty acids, which are required for the transport of these fatty acids into mitochondria for beta-oxidation) [ 47 , 48 ] ( Table 1 ). A representative example is that while metabolomics predicts activation of the gluconeogenetic pathway “glucose anlanine cycle”, proteomics also demonstrates an increase in gluconeogenesis proteins.…”

Section: Resultsmentioning

confidence: 99%

The Beneficial Effect of Mitochondrial Transfer Therapy in 5XFAD Mice via Liver–Serum–Brain Response

Sweetat

Nitzan

Suissa

et al. 2023

Cells

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We recently reported the benefit of the IV transferring of active exogenous mitochondria in a short-term pharmacological AD (Alzheimer’s disease) model. We have now explored the efficacy of mitochondrial transfer in 5XFAD transgenic mice, aiming to explore the underlying mechanism by which the IV-injected mitochondria affect the diseased brain. Mitochondrial transfer in 5XFAD ameliorated cognitive impairment, amyloid burden, and mitochondrial dysfunction. Exogenously injected mitochondria were detected in the liver but not in the brain. We detected alterations in brain proteome, implicating synapse-related processes, ubiquitination/proteasome-related processes, phagocytosis, and mitochondria-related factors, which may lead to the amelioration of disease. These changes were accompanied by proteome/metabolome alterations in the liver, including pathways of glucose, glutathione, amino acids, biogenic amines, and sphingolipids. Altered liver metabolites were also detected in the serum of the treated mice, particularly metabolites that are known to affect neurodegenerative processes, such as carnosine, putrescine, C24:1-OH sphingomyelin, and amino acids, which serve as neurotransmitters or their precursors. Our results suggest that the beneficial effect of mitochondrial transfer in the 5XFAD mice is mediated by metabolic signaling from the liver via the serum to the brain, where it induces protective effects. The high efficacy of the mitochondrial transfer may offer a novel AD therapy.

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Section: Resultsmentioning

confidence: 99%

The Beneficial Effect of Mitochondrial Transfer Therapy in 5XFAD Mice via Liver–Serum–Brain Response

Sweetat

Nitzan

Suissa

et al. 2023

Cells

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“…5 Therefore, it is necessary to develop safe and effective drugs to treat DN. 6 Baicalin (BA), a natural flavone glycoside extracted from Scutellaria root, displays multiple pharmacological effects, such as antineoplastic, antimicrobial, antioxidant, and anti-inflammatory activities. 7 BA is reported to exert the protective effects in various human diseases.…”

Section: Introductionmentioning

confidence: 99%

Baicalin Exerts a Protective Effect in Diabetic Nephropathy by Repressing Inflammation and Oxidative Stress Through the SphK1/S1P/NF-κB Signaling Pathway

Ren¹,

Jiao²,

Yan³

et al. 2023

DMSO

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Background: Inflammation and oxidative stress contribute to the development of diabetic nephropathy (DN). Baicalin (BA) shows renal protection against DN through its anti-inflammatory and anti-oxidant properties. However, the molecular mechanism by which BA exerts the therapeutic effects on DN remains to be investigated. Methods: The db/db mice and high glucose (HG)-induced HK-2 cells were used as the in vivo and in vitro model of DN, respectively. The effects of BA were assessed by detecting the related blood and urine biochemical parameters, kidney histopathology, inflammatory cytokine production, oxidative stress indicators, and apoptosis. Cell viability and apoptosis were detected by CCK-8 assay and TUNEL assay, respectively. Related protein levels were measured by an immunoblotting method. Results: In db/db model mice, BA reduced serum glucose concentration, decreased blood lipid levels, ameliorated kidney functions, and decreased histopathological changes in kidney tissues. BA also alleviated oxidative stress and inflammation in db/db mice. In addition, BA blocked the activation of sphingosine kinases type 1/sphingosine 1-phosphate (SphK1/S1P)/NF-κB pathway in db/db mice. In HK-2 cells, BA hindered HG-induced apoptosis, oxidative stress and inflammation, while overexpression of SphK1 or S1P could reverse these effects. BA alleviated HG-induced apoptosis, oxidative stress and inflammation in HK-2 cells through the S1P/NF-κB pathway. Furthermore, BA blocked the NF-κB signaling by diminishing p65 nuclear translocation via the SphK1/S1P pathway. Conclusion: Our study strongly suggests that BA protects against DN via ameliorating inflammation, oxidative stress and apoptosis through the SphK1/S1P/NF-κB pathway. This study provides a novel insight into the therapeutic effects of BA in DN.

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“…The liver is also important for systemic nucleotide homeostasis and local intercellular signaling in the hepatic lobules, canalicular networks, and biliary systems. Due to the rise in triacylglycerol levels caused by detergents, dyslipidemia also develops and may cause an increase in the liver function tests 20,21 . Liver regulates essential hepatic processes including purinergic signaling, cell homeostasis, glycogen metabolism, bile secretion, and blood flow 22 .…”

Section: Introductionmentioning

confidence: 99%

“…Due to the rise in triacylglycerol levels caused by detergents, dyslipidemia also develops and may cause an increase in the liver function tests. 20,21 Liver regulates essential hepatic processes including purinergic signaling, cell homeostasis, glycogen metabolism, bile secretion, and blood flow. 22 The kidney, a vital organ with a significant perfusion rate, is a target tissue for xenobiotics with various toxic effects.…”

mentioning

confidence: 99%

Carvacrol protects against λ‐Cyhalothrin‐induced hepatotoxicity and nephrotoxicity by modulating oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy

İleritürk

Kandemir

2023

Environmental Toxicology

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λ-Cyhalothrin, a type II synthetic pyrethroid, has been widely used in households, agriculture, public health, and gardening to control insect pests. Despite its widespread usage, it is known to induce a variety of adverse effects, including hepatotoxicity and nephrotoxicity. The goal of this study was to investigate the protective effect of carvacrol, which has antioxidant, anti-inflammatory, anti-apoptotic, and some other properties, on λ-Cyhalothrin-induced hepatotoxicity and nephrotoxicity 35 male Sprague-Dawley rats were randomly divided into five groups for this purpose: I-Control group: II-CRV group (50 mg/kg carvacrol), III-LCT group (6.23 mg/kg LCT), IV-LCT + CRV 25 group (6.23 mg/kg LCT + 25 mg/kg carvacrol), and V-LCT + CRV 50 group (6.23 mg/kg LCT + 50 mg/kg carvacrol). Using biochemical, realtime PCR, and western blotting methods, the collected tissues were analyzed. While λ-Cyhalothrin treatment increased MDA levels, which are indicated of lipid peroxidation, but reduced SOD, CAT, GPx activities, and GSH levels. After receiving carvacrol therapy, the degree of oxidative stress reduced as the values of these parameters approached those of the control group. Increased inflammation, apoptosis, endoplasmic reticulum stress, and autophagy with λ-Cyhalothrin administration reduced with carvacrol co-administration, and liver and kidney tissues were protected from damage, depending on the degree of oxidative stress. After considering all of these data, it was discovered that λ-Cyhalothrin-induced oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy in the liver and kidneys; however, carvacrol protected the tissues from damage. Our findings indicate that carvacrol may be a promising protective agent in λ-Cyhalothrin-induced hepatotoxicity and nephrotoxicity.

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Assessment of hypolipidemic and anti‐inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton WR‐1339‐induced hyperlipidemia in rat kidney, liver, and heart

Cited by 37 publications

References 104 publications

The Beneficial Effect of Mitochondrial Transfer Therapy in 5XFAD Mice via Liver–Serum–Brain Response

The Beneficial Effect of Mitochondrial Transfer Therapy in 5XFAD Mice via Liver–Serum–Brain Response

Baicalin Exerts a Protective Effect in Diabetic Nephropathy by Repressing Inflammation and Oxidative Stress Through the SphK1/S1P/NF-κB Signaling Pathway

Carvacrol protects against λ‐Cyhalothrin‐induced hepatotoxicity and nephrotoxicity by modulating oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy

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