Assessment of<i>in vitro</i>antipsoriatic activity of selected Indian medicinal plants

Singh, Suman Kumar; Chouhan, Hemendra S.; Sahu, Alekh N.; Narayan, Gopeshwar

doi:10.3109/13880209.2014.976713

Cited by 12 publications

(2 citation statements)

References 27 publications

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“…In HaCaT cells, the extracts inhibited lipid peroxidation and NO production. This suggested that the antioxidant mechanism contributes to the anti-psoriatic activity of the extracts 32 .…”

Section: Aqueous Extracts Of Psoralea Corylifolia Andmentioning

confidence: 99%

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2021

IJPSR

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Psoriasis is a skin disorder marked with inflammation. The development and progression of the disease are associated with a chronic inflammatory response, which is attributed to the dysregulated innate immune system. The dendritic cells and T cells secrete various cytokines leading to disturbances in the keratinocyte proliferation and differentiation. Several medications are available for the mitigation of psoriasis. The currently used antipsoriatic medications are expensive; carry the threat of serious side-effects and frequent remission attacks of the disease. Exploring safer and effective antipsoriatic drugs remains still a major concern. Natural products represent important treatment options for psoriasis. This review article discusses studies related to the topical formulations of anti-psoriatic plants and plant products. The pathogenesis and clinical symptoms of psoriasis include multiple immunological mechanisms and pro-inflammatory cytokines. The review aims to summarize the research done in this area and to explain the mechanism of action of herbal medicines. The review article is aimed at opening new medical approaches for treating psoriasis. All the findings suggested that various herbal constituents are responsible for anti-psoriatic activity. Herbal medicines can be used as promising anti-psoriatic agents. The antipsoriatic effects of herbal medicines are through modulation of the signaling pathways of the cells. The phytoconstituents inhibit keratinocytes proliferation and differentiation by targeting different molecular targets. The results suggested the use of plants as a safe, effective, and inexpensive option for treating psoriasis.

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“…In HaCaT cells, the extracts inhibited lipid peroxidation and NO production. This suggested that the antioxidant mechanism contributes to the anti-psoriatic activity of the extracts 32 .…”

Section: Aqueous Extracts Of Psoralea Corylifolia Andmentioning

confidence: 99%

Untitled

2021

IJPSR

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“…Whorls are terminal, large and axillary, about 2.5cm in diameter and crowded with white bell shaped flowers. Calyx is variable, with an upper lip and short, triangular teeth [23].…”

Section: Leucas Asperamentioning

confidence: 99%

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2017

GJPPS

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Psoriasis is a very common chronic, disfiguring, inflammatory condition of the skin. This problem has a profound psychological impact on lowering self-esteem and interpersonal relationships. This skin disorder is seen worldwide and is thus a matter of serious concern. The prescribed synthetic drugs available in the market for the treatment of psoriasis are associated with different adverse effects, so researchers around the world are searching for new, effective, and safer drugs from natural resources. Many medicinal plants are available in nature and these plants are used for treating skin diseases. Virtually all human beings continue to rely on medicinal plants for skin diseases. The aim of this paper is to discuss the beneficial effects of assured medicinal plants for wide awareness of their utility for the treatment of Psoriasis. Plants chosen for these purposes have medicinally significant value; many of them possess active phytochemical constituents and are known as anti-psoriatic plants.

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Outline of Therapeutic Potential of Different Plants Reported Against Psoriasis via In Vitro, Pre‐Clinical or Clinical Studies

Gupta,

Kalvatala,

Joseph

et al. 2025

Phytotherapy Research

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Psoriasis is a noncontagious, autoimmune chronic inflammatory disease with an unknown root cause. It is classified as a multifactorial and chronic skin disorder that also affects the immune system and is genetic. Environmental factors such as stress, infections, and injuries all play an important role in the disease's development. Although there is no cure for this disease, topical, oral, and systemic whole‐body treatments are available to relieve symptoms. Several plants and phytochemicals which have been found effective in the management of the psoriasis experimentally (preclinical and clinical). These plants/phytochemicals have applications in topical, oral, and systemic treatments. Traditionally, some of the plants have been utilized as the primary treatment, including their extracts and/or phytochemicals, for individuals with moderate to severe psoriasis (due to fewer side effects), while phototherapy is generally reserved for more advanced cases. This report describes various plants and phytochemicals that have been found to be effective against psoriasis in in vitro, preclinical, and clinical studies. This review summarizes the key findings from experimental studies on various pathological aspects of psoriasis and may be useful, effective, and informative for future research.

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Assessment ofin vitroantipsoriatic activity of selected Indian medicinal plants

Cited by 12 publications

References 27 publications

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Outline of Therapeutic Potential of Different Plants Reported Against Psoriasis via In Vitro, Pre‐Clinical or Clinical Studies

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