Assessment of IL-17 in Oral Lichen Planus and in Pemphigus Vulgaris

El-Refai, Ibrahim; Maged, Amira; El-Saady, Dina

doi:10.21608/edj.2015.71422

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Another study was conducted in 2019, assessing serum and salivary levels of interleukin 17 in oral lichen planus patients. In this study, El-Refai et al reported higher mean levels with significant results for the cases group compared to controls [51]. In 2017, Shiva Shirazian et al studied salivary IL17 and IL22 levels in oral lichen planus and control groups.…”

Section: Main Textmentioning

confidence: 56%

A review on interleukins (IL10 and IL17) as biomarkers for hepatitis C-associated oral lichen planus

Hirani

Charania

Salim³

et al. 2022

Egypt Liver Journal

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Background Hepatitis C virus is a viral infection associated with autoimmune disorders. This virus has hepatic and extrahepatic manifestations. One of the extrahepatic manifestations associated with the hepatitis C virus includes oral lichen planus. Oral lichen planus is an autoimmune disorder mainly affecting the tongue and buccal mucosa. It clinically represents grayish-white striae bilaterally on the buccal mucosa. The pathogenesis involves the progression of the hepatitis C virus, and oral lichen planus affects T lymphocytes. Specific proteins and cytokines activate these T lymphocytes, which act as biomarkers to detect certain diseases. Interleukin 10 is an anti-inflammatory cytokine, whereas interleukin 17 is a pro-inflammatory cytokine. These cytokines have a pathophysiological role and act as biomarkers for many diseases. Therefore, this review article aims to establish the role of interleukin 10 and interleukin 17 as biomarkers for hepatitis C-associated oral lichen planus. Conclusion Hepatitis C virus is an infectious disease that can lead to liver cirrhosis, and oral lichen planus is a premalignant lesion that can lead to oral carcinoma. As interleukin 10 lessens the immune pathologies and interleukin 17 mediates proinflammatory response, therefore, these biomarkers have a role in progression of these diseases.

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Section: Main Textmentioning

confidence: 56%

A review on interleukins (IL10 and IL17) as biomarkers for hepatitis C-associated oral lichen planus

Hirani

Charania

Salim³

et al. 2022

Egypt Liver Journal

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“…This finding may indicate higher level of disease activity in erosive OLP patients. 26,44,79,88 MiRNA-155 plays a pivotal role in the immune system of mammals especially in the regulation of T-helper differentiation. A cell experiment revealed that miRNA-155 can inhibit the release of pro-inflammatory mediators, such as IL-8, IL-6 and TNF-alpha by MyD88.…”

Section: Discussionmentioning

confidence: 99%

“…88 Several studies showed significant upregulation of IL-17 in tissue, serum, and saliva samples of OLP patients compared with healthy controls. 2,9,11,15,16,23,32,44,78,79,82,[88][89][90][91] Considering T-cell-mediated immune response in pathogenesis of OLP, presence of IL-17 and its regulatory role in OLP is not surprising. It participates in the pathogenesis of OLP through the following mechanisms: (I) reinforcement of T lymphocyte reactions and production of inflammatory mediators such as IL-6, IL-8, and IL-1B, 15,78 (II) regulation of production of matrix metalloproteinase-9 (that breaks type IV collagen leading to impairment of the basement membrane and apoptosis of keratinocytes), 92,93 (III) reduction in diversity of oral bacteria (providing an opportunity for opportunistic pathogens to stimulate the innate and acquired immune system and lead to disease flare-up), 88 (IV) and increased hypersensitivity reactions (through degranulation of mast cells).89 Th17 cells are imperative to coordinate the immune responses elicited by extracellular bacteria and fungi.…”

Section: Discussionmentioning

confidence: 99%

“…37,43 Infiltration of T lymphocytes is highly important in initiation and progression of OLP, which elicits inflammatory responses in lamina propria and epithelial layer and causes apoptosis of keratinocytes in oral epithelium. 44 T-helper cells had two separate subgroups before to 2005, each of which had unique cytokine characteristics and immune system roles. 45 Interferon C and tumor necrosis factor (TNF)alpha, which are often produced by T-helper 1 (Th1) cells, are involved in macrophage activity and the distinction between chronic infections and autoimmune disorders.…”

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confidence: 99%

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A Systematic Review of Interleukin-17 in Oral Lichen Planus: From Etiopathogenesis to Treatment

Agha-Hosseini,

Moosavi,

Bahrami

2023

Clin Med Res

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Lichen planus (LP) is a chronic autoimmune disease of skin and mucous membranes. World Health Organization has announced oral lichen planus (OLP) as a premalignant lesion. The exact etiology of OLP remains unknown; however, different mechanisms may be involved in its immunopathogenesis. The upregulation of cytokines, chemokines, and adhesion molecules is consistent with a persistent and erratic immunological response to OLP-mediated antigens generated by oral keratinocytes and innate immune cells. These molecules attract T cells, and mast cells to the disease site and regulate complex interactions among cells that lead to death of keratinocytes, degradation of basement membrane, and chronicity of the disease. It is believed that CD8+ and CD4+ T helper 1 (Th1) cells are the main lymphocytes involved in this process, although recent evidence suggests implication of other T helper subgroups, such as Th23, Th17, and regulatory T cells (Tregs), proposing a more complex cellular immunity process to be involved in its pathogenesis. The emphasis of this research review is on the function of IL-17 in the pathophysiology of OLP and how current discoveries may point to future treatment strategies. This research protocol will follow Preferred Reporting Items for Systematic Reviews (PRISMA 2020) checklist. An electronic search was conducted in PubMed, Scopus, Google Scholar, Embase, and Cochrane databases for articles published from 1960 to June 2022. Based on the eligibility criteria, 21 articles were enrolled. In comparison to healthy controls, the findings of this review demonstrated greater expression of IL-17 and Th-17 in the blood, saliva, and tissues of OLP and LP patients. Additionally, there was a strong link between the relative levels of IL-17 and IL-23 expression. Treatment with monoclonal antibodies against Th-17/Tc-17, IL-12/IL-23, and IL-23 would result in significant long-term improvement of LP symptoms.

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Assessment of the Level of Interleukin-17 in Saliva in Patients With Various Forms of Lichen Planus

Zainullin,

Ivanova,

Moiseev

et al. 2024

Actual Problems in Dentistry

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Lichen planus (LP) of the oral cavity is a chronic inflammatory disease characterized by symmetrical, multiple lesions of the oral mucosa. The etiology and pathogenesis of LP have not yet been fully studied; however, it is assumed that the immune response of the body plays a key role in the development of the disease. One of the important mediators of the inflammatory response in LP is interleukin-17 (IL-17), a cytokine that is secreted by activated T lymphocytes. IL-17 promotes the recruitment of monocytes and neutrophils to the site of inflammation, and also stimulates the production of other pro-inflammatory cytokines, which can contribute to the chronization and progression of the disease. LP is a significant clinical problem due to the frequent recurrence and lack of effective therapies aimed at correcting immune disorders. The purpose of the study was to assess the level of IL-17 in saliva in patients with various forms of oral CPL. The study included 40 participants divided into three groups: Group I consisted of 20 patients with erosive and ulcerative form of LP; Group II included 10 patients with reticular form of LP; Group III consisted of 10 patients without LP (comparison group). The concentration of IL-17 in saliva samples was assessed by enzyme immunoassay (ELISA). In addition, clinical evaluation and pain assessment were performed. Clinical and pain indicators were significantly higher in the group with erosive and ulcerative form of LP (the first group), compared with the second and third groups. IL-17 levels were higher in patients with erosive and ulcerative form of LP (44.37 ± 2.19 pg/ml) than in patients with reticular form of LP and patients in the comparison group. The level of IL-17 speaks not only about the inflammatory course of LP, but also provides diagnostic information about the severity of the course of this disease.

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Assessment of IL-17 in Oral Lichen Planus and in Pemphigus Vulgaris

Cited by 4 publications

References 18 publications

A review on interleukins (IL10 and IL17) as biomarkers for hepatitis C-associated oral lichen planus

A review on interleukins (IL10 and IL17) as biomarkers for hepatitis C-associated oral lichen planus

A Systematic Review of Interleukin-17 in Oral Lichen Planus: From Etiopathogenesis to Treatment

Assessment of the Level of Interleukin-17 in Saliva in Patients With Various Forms of Lichen Planus

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