Assessment of Immunohistochemical Expression of Androgen Receptor and its Correlation with Histopathological Prognostic Factors in Prostatic Carcinoma

Abstract

Background: Prostate carcinoma (PCa) is the second most commonly diagnosed tumor in men worldwide and is the most common male malignancy in developed countries. Androgens play a main role in the growth, differentiation, and maintenance of prostate tissue via Androgen Receptor (AR). AR expression represents a potential prognostic marker for prostatic carcinoma. Aim: this study aims to assess of immunohistochemical expression of the Androgen receptor and its correlation with histopathological prognostic factors in Prostatic carcinoma. Methods: A cross-section analytical study was conducted at the pathology department of the Faculty of Medicine at Suez Canal University. Thirty-five prostatic specimens with prostate cancer were analyzed for immunohistochemichal expression of the Androgen receptor [AR (A19611)]. Results: Out of the studied thirty-five specimens. There is a statistically significant difference between different grade groups regarding AR expression (P value =0.008) & there is a statistically significant difference between different Gleason scores regarding AR expression (P value =0.001). There is no statistically significant difference between AR expression and Age of patients, Perineural invasion, multicenticity, and no benign prostatic changes. Conclusions: This study focused on evaluating the relationship of Androgen Receptor expression with various prognostic factors associated with carcinoma prostate, AR was upregulated in prostate cancer; mainly in cancers with a worse prognosis which has a higher Gleason Score and higher-grade group.