River floodplains such as the Barotse Flood Plain (BFP) in Western Zambia, provide a large number of ecosystem services and economic value for the inhabitants. Yet, in spite of its importance, the flood plain has been vulnerable to drivers of land use change suggestive of potential wetland degradation. This study aimed at determining the extent of land use change in the wetland of BFP in the selected years between 1980 to 2020 and identifying, and assessing drivers of land use change in the wetlands of BFP using satellite data. The study utilized both secondary and primary data sources. Primary data was collected using interview schedule, key informants’ interviews, Participatory Rural Appraisal and field observations. The Raosoft random sample calculator was used to determine the sample size of heads of households from 9 districts that are found within the Barotse Flood Plain. Then, proportional sample size per district out of 270 was calculated. It was found that there is land use change in the wetlands of BFP caused by many driving factors such as biophysical, economic, infrastructure development, technological, demographic, agriculture and others. The study recommended strategies such as the Government of Zambia, traditional leaders and other stakeholder should embark on protection and conservation of BFP. In addition, new policies on land use and water resources management in the wetlands such regularly monitoring of all activities taking place in and around the wetland of BFP by Water Resources Management Authority should be explored.