Assessment of Inflammation with Hematological Parameters in Patients with Migraine and Tension-Type Headache: A Prospective Study from A Tertiary Care Center

Albayrak, Halil Okay; Gürbüz, Hande; Basaran, Sehnaz; Yılmaz, Serkan

doi:10.2217/pmt-2021-0036

Cited by 6 publications

(6 citation statements)

References 40 publications

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“…In summary, some of the studies reported a higher neutrophil [ 4 – 6 ], platelet [ 5 ] counts, and lower lymphocyte counts [ 4 , 5 ] in migraine patients during the ictal period compared to healthy controls. However, these findings were not replicated by other studies [ 5 – 7 , 9 ]. In addition, previous studies were hospital-based and conducted within a selected group of participants suffering from migraine attacks severe enough to warrant admission to a hospital.…”

Section: Discussioncontrasting

confidence: 82%

No association between blood-based markers of immune system and migraine status: a population-based cohort study

Acarsoy,

Ruiter,

Bos

et al. 2023

BMC Neurol

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Background Although some evidence implicates the immune system in migraine attacks, its role during attack-free periods remains largely unexplored. Therefore, we assessed the association between the immune system and migraine status. Methods From the population-based Rotterdam Study, we included 6593 participants who underwent blood sampling and migraine assessments. In the blood samples, we measured white blood-cell-based immune markers. As a marker for the innate immune system, granulocyte and platelet counts were determined, whereas lymphocyte counts were used as a marker for the adaptive immune system. Migraine was assessed using a validated questionnaire based on ICHD-2 criteria. We investigated associations between blood-cell counts and migraine using logistic regression models adjusting for age, sex and other variables. Results Mean age of participants was 65.6 ± 11.2 years and 56.7% were female. The lifetime prevalence of migraine was 15.1% (995/6593). We found no statistically significant associations between granulocyte (odds ratio [OR] per standard deviation increase 1.01 95% Confidence Interval [CI]: 0.93–1.09), platelet (OR 1.01 CI: 0.94–1.09) or lymphocyte counts (OR 1.01 CI: 0.93–1.08) and migraine status. Conclusions Our results do not support an association between white blood-cell-based immunity markers and migraine status.

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Section: Discussioncontrasting

confidence: 82%

No association between blood-based markers of immune system and migraine status: a population-based cohort study

Acarsoy,

Ruiter,

Bos

et al. 2023

BMC Neurol

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“…The number of studies examining TTH and peripheral inflammation is limited [6,7]. The effects of systemic inflammation on tension-type headache are not clearly known.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory and infectious parameters in tension-type headache

Yilmaz

2023

Health Sci. Q.

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Although tension-type headache (TTH) is the most common primary headache in the world, much fewer studies on its pathophysiology have been carried out in comparison to other primary headaches. Inflammatory processes are important in the pathophysiology of both peripheral and central pain. Studies on the role of inflammatory markers in TTH patients are limited. Therefore, in this study, it was aimed to examine the role of inflammatory parameters in TTH. 199 TTH patients and 154 control participants were involved in this study. C-reactive protein (CRP) and high-density lipoprotein (HDL) levels and neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), monocyte/lymphocyte (MLR), HDL/monocyte and Immature/Total granulocyte ratios in all patients reviewed retrospectively. CRP value and immature/total granulocyte ratio were found to be significantly higher in the patient group when compared to the control group. No difference was found between NLR, PLR, MLR, and HDL/Monocyte ratios. There was no difference in NLR, MLR, immature/mature granulocyte ratios, and CRP values between the genders in the patient group. Median values of PLR, HDL, and HDL / monocyte were found to be higher in males. The fact that there is no difference in most of the inflammatory parameters in TTH and there is a significant difference in the immature/total granulocyte ratio is a new finding on this subject. There is no other study in the literature examining the immature/total granulocyte ratio in headaches.

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“…Our results are consistent with these previous studies. By contrast, a prospective controlled observational study showed that, although high in headache patients, there were no significant differences in the NLR among migraine, TTH, and controls [ 22 ]. Our nMH group included patients with diagnostic codes for TTH or non-specific headache; all types of migraine were excluded.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, systemic inflammation parameters, including the NLR, PLR, and CRP level, are significantly elevated in chronic TTH patients [ 21 ]. However, in a prospective study that investigated the roles of inflammatory markers in migraine and TTH patients during acute headache attack, the NLR did not show a significant difference between groups [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Peripheral Inflammatory Markers in Patients with Acute Headache Attack to Differentiate between Migraine and Non-Migraine Headache

Lee

Kim

Kwon

et al. 2022

JCM

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Although the potential relationship between headaches, particularly migraine, and peripheral inflammatory markers (PIMs) has been investigated, it is unclear whether PIMs are involved in the pathogenesis of migraine or can differentiate it from non-migraine headaches (nMHs). Using 10 years of data from the Smart Clinical Data Warehouse, patients who visited the neurology outpatient department (OPD) within 30 days after visiting the emergency room (ER) for headaches were divided into migraine and nMH groups, the PIMs were compared including the neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR) ratios, and neutrophil-to-monocyte ratio (NMR). Of the 32,761 patients who visited the ER for headaches, 4005 patients visited the neurology OPD within 30 days. There were significant increases in the NLR, MLR, and NMR, but a lower PLR in the migraine and nMH groups than the controls. The NMR was significantly higher in the migraine than the nMH group. A receiver operating characteristic curve analysis showed that the ability of the NLR and NMR to differentiate between migraine and nMHs was poor, whereas it was fair between the migraine groups and controls. The elevated PIMs, particularly the NLR and NMR, during headache attacks in migraineurs suggest that inflammation plays a role in migraine and PIMs may be useful for supporting a migraine diagnosis.

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Assessment of Inflammation with Hematological Parameters in Patients with Migraine and Tension-Type Headache: A Prospective Study from A Tertiary Care Center

Cited by 6 publications

References 40 publications

No association between blood-based markers of immune system and migraine status: a population-based cohort study

No association between blood-based markers of immune system and migraine status: a population-based cohort study

Inflammatory and infectious parameters in tension-type headache

Role of Peripheral Inflammatory Markers in Patients with Acute Headache Attack to Differentiate between Migraine and Non-Migraine Headache

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