Assessment of inflammatory jaw pathologies using bone SPECT/CT maximum standardized uptake value

Abstract

Objectives: To investigate the assessment of inflammatory jaw pathologies using bone single-photon emission CT-CT (SPECT/CT) maximum standardized uptake value (SUVmax). Methods: 44 patients with inflammatory jaw pathologies (7 chronic osteomyelitis, 8 osteoradionecrosis and 29 medication-related osteonecrosis of the jaw (MRONJ)) underwent SPECT/CT at 4 h after injection of 99mTc hydroxymethylene diphosphonate. The SPECT/CT parameters SUVmax of the inflammatory jaw pathologies were analyzed. Statistical analyses for the SUVmax were performed by one-way repeated measures analysis of variance with Tukey's honestly significant difference test. A p-value lower than 0.05 was considered statistically significant. Results: The mean and standard deviation of SUVmax for 7 chronic osteomyelitis, 8 osteoradionecrosis and 29 MRONJ were 24.94 ± 3.65, 12.27 ± 5.47 and 16.55 ± 9.12, respectively. The SUVmax for chronic osteomyelitis were significantly higher than those for osteoradionecrosis (p = 0.011) and MRONJ (p = 0.043). Conclusions: Bone SPECT/CT SUVmax in the uptake of 99mTc hydroxymethylene diphosphonate reflecting bone physiological changes for chronic osteomyelitis were significantly higher than those of osteonecrosis, such as osteoradionecrosis and MRONJ. Bone SPECT/CT SUVmax should be useful for the assessment of inflammatory jaw pathologies, such as chronic osteomyelitis, osteoradionecrosis and MRONJ.

Clinical Diagnostic Imaging Study of Osteoradionecrosis of the Jaw: A Retrospective Study

“…In this study, we obtained information on the existence of ORN; however, the detailed situation of ORN could not be evaluated because of the low level of specificity [13]. Since the development of bone SPECT can aid in various quantitative SUV analyses, SPECT/CT is a promising modality for the analysis of ORN [42].…”

“…PET/CT findings of ORN reflect the disease course and indicate the point of clinical remission in patients with chronic osteomyelitis [40][41][42]. PET is effective in detecting tumor recurrence.…”

“…The degree of trismus would improve with surgical resection of the necrotic bone, however, with only conservative treatments, it is unclear whether trismus can be improved. PET/CT findings of ORN reflect the disease course and indicate the point of clinical remission in patients with chronic osteomyelitis [40][41][42]. PET is effective in detecting tumor recurrence.…”

Management von medikamentenassoziierten Kiefernekrosen – Ergebnisse einer Literaturanalyse neuester Studien im Vergleich zu bewährten Strategien

“…Nach Anwendung der Ausschlusskriterien waren noch 7 Studien zur Auswertung geeignet (Tab. 4 ; [ 7 , 9 , 18 , 21 , 22 , 40 , 44 ]). Die meisten Studien zur Diagnostik untersuchten die Ergebnisqualität unterschiedlicher MRT-Verfahren und nuklearmedizinischer Diagnostik in der Differenzierung zwischen MRONJ und gesunden Knochenarealen oder von MRONJ im Unterschied zu anderen entzündlichen Erkrankungen der Kieferknochen.…”

“…B. Orthopantomogramm), Schnittbildverfahren (DVT, CT, MRT) und nuklearmedizinische Verfahren zum Einsatz [ 9 ]. Die neuesten Studien untersuchen die Verfeinerung der diagnostischen Aussagekraft bereits bekannter Techniken [ 9 , 18 , 21 , 40 , 44 ].…”