Assessment of inhaled corticosteroids use and associated factors among asthmatic patients attending Tikur Anbessa Specialized Hospital, Ethiopia

Ayele, Yohanes; Engidawork, Ephrem; Bayisa, Tola

doi:10.1186/s13104-017-2645-2

Cited by 10 publications

(11 citation statements)

References 18 publications

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“…Among the included studies the prevalence of nonadherence to inhaled medications varied from 15.1% reported by Ayele et al [23] to 59% reported by Koyra and Table 1 Characteristics of studies included in the systematic review and meta-analysis of the non-adherence to inhaled medications among asthmatic patients in Ethiopia, 2020 Chinasho [22]. To look at the heterogeneity of the included studies, we conducted subgroup analysis by regions.…”

Section: Discussionmentioning

confidence: 99%

“…Although several studies have been published on the prevalence and associated factors of non-adherence to inhaled medications among adult asthmatic patients in Ethiopia [18][19][20][21][22][23], the general prevalence remains unknown. Therefore, the primary purpose of this systematic review and meta-analysis is to determine the pooled national prevalence of non-adherence to inhaled medications among adult asthmatic patients in Ethiopia.…”

Section: Introductionmentioning

confidence: 99%

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Non-adherence to inhaled medications among adult asthmatic patients in Ethiopia: a systematic review and meta-analysis

Aberhe

Hailay

Zereabruk

et al. 2020

asthma res and pract

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Background Medication non-adherence is one of a common problem in asthma management and it is the main factor for uncontrolled asthma. It can result in poor asthma control, which leads to decreased quality of life, increase hospital admission, increased health care utilization, lost productivity, and mortality. To date, there have been no studies and protocols that estimated the pooled national prevalence of non-adherence to inhaled anti-asthmatic medications in Ethiopia. Therefore, the primary purpose of this systematic review and meta-analysis is to determine the pooled national prevalence of non-adherence to inhaled medications among asthmatic patients in Ethiopia. Methods Different database searching engines including PubMed, Scopus, Google Scholar, Africa journal online, World Health Organization afro library, and Cochrane review were systematically searched by using keywords such as “prevalence, non-adherence to inhaled medications, inhaled corticosteroids, and asthmatic patients” and their combinations. Six published observational studies that report the prevalence of non-adherence to inhaled medications were finally selected. The Preferred Reporting Items for Systematic Review and Meta-Analysis guideline was followed. Heterogeneity across the included studies was evaluated by the inconsistency index (I2). The random-effect model was fitted to estimate the pooled prevalence of non-adherence to inhale anti-asthmatic medications. All statistical analysis was done using R version 3.5.3 and R Studio version 1.2.5033 software for windows. Results The pooled national prevalence of non-adherence to inhaled medications among asthmatic patients was 29.95% (95% CI, 19.1, 40.8%). The result of this meta-analysis using the random-effects model revealed that there is high heterogeneity across the included studies. The result of subgroup analysis indicates that one out of three in the Oromia region and one out of five in the Amhara region asthmatic patients was non-adherent to their inhaled anti-asthmatic medications. Conclusion the prevalence of non-adherence to inhaled anti-asthmatic medications was high. Thus, our finding suggests that one out of four asthmatic patients were non-adherent to inhaled medications. The ministry of health, health policymakers, clinicians, and other health care providers should pay attention to strengthening the adherence levels to inhaled anti-asthmatic medications, and country-based interventions should be developed to reduce the burden of non-adherence to inhaled anti-asthmatic medications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non-adherence to inhaled medications among adult asthmatic patients in Ethiopia: a systematic review and meta-analysis

Aberhe

Hailay

Zereabruk

et al. 2020

asthma res and pract

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“…Each item is scored using a 1-5 scale and then summed up (total score, . The score was then classified as well controlled (20)(21)(22)(23)(24)(25), not well controlled (16)(17)(18)(19), and very poorly controlled (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) asthma. For the purpose of data analysis, the total score was dichotomized.…”

Section: Asthma Control Test (Act) Andmentioning

confidence: 99%

“…Moreover, for people in older age groups, premature death due to asthma contributes more to the burden of disease [4]. Unavailability of appropriate and affordable medications, poor knowledge of patients, and poor communication between physician and patient increased the burden of asthma in Ethiopia [5].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Asthma Control and Quality of Life among Asthmatic Patients Attending Armed Forces Referral and Teaching Hospital, Addis Ababa, Ethiopia

2020

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Background. The primary goal of asthma management is to achieve good asthma control. However, poor patient-physician communication, unavailability of appropriate medications, and lack of long-term goals have made asthma control difficult in developing countries. Poor assessment of asthma control and quality of life is a major cause of suboptimal asthma treatment worldwide, and information regarding this issue is scanty in developing countries like Ethiopia. This study thus attempted to assess the level of asthma control and quality of life in asthmatic patients attending Armed Forces Referral and Teaching Hospital. Methods. A cross-sectional study comprising 184 physician-diagnosed asthmatic patients was conducted using interview, chart review, and prescription assessment. Asthma control was assessed using Asthma Control Test, while asthma quality of life was assessed using Mini-Asthma Quality of Life Questionnaire (mini-AQLQ). Spearman’s rank correlation analysis was performed to understand the relationship between mean mini-AQLQ score and asthma control. Receiver operating characteristic curve analysis was performed to establish cut-off values for mini-AQLQ. Results. Asthma was uncontrolled in 67.9% subjects. There was a strong correlation between asthma control and quality of life (rs=0.772; P<0.01). A cut-off value for the quality of life was established at 4.97. Majority of the patients were taking two or three antiasthmatic drugs. Oral tablet and inhaler short-acting beta agonists (SABA) were the frequently combined drugs. Uncontrolled asthma was associated with middle-aged adults (adjusted odds ratio AOR=6.31; 95% CI: 2.06, 19.3; P=0.001), male gender (AOR=0.38; 95% CI: 0.15, 0.98; P=0.044), married (AOR=0.24; 95% CI: 0.08, 0.78; P=0.017), comorbidities (AOR=0.23; 95% CI: 0.09, 0.61; P=0.003), and oral SABA use (AOR=0.22; 95% CI: 0.09, 0.59; P=0.003). Male gender (AOR=0.36; 95% CI: 0.16, 0.84; P=0.018), intermittent asthma (AOR=0.18; 95% CI: 0.04, 0.86; P=0.032), use of oral corticosteroids (AOR=0.22; 95% CI: 0.06, 0.73; P=0.013), and SABA (AOR=0.39; 95% CI: 0.17, 0.89; P=0.026) were found to have a significant association with poor asthma-related quality of life. Conclusion. The findings collectively indicate asthma remains poorly controlled in a large proportion of asthma patients in the study setting. Moreover, quality of life appears to be directly related to asthma control. Healthcare providers should therefore focus on asthma education with an integrated treatment plan to improve asthma control and quality of life.

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“…Most of these deaths can be avoided through timely and appropriate treatment. Medications used in asthma are classi ed as relievers and controller [3]. These are corticosteroids and leukotriene modi ers and bronchodilators.…”

Section: Introductionmentioning

confidence: 99%

Plasma Glucose Levels of Asthma Patients Using Inhaled Fluticasone

Rahman

Hasan

Rahim

et al. 2020

Preprint

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Objective: Inhaled fluticasone is used in asthma for a long duration. However, It’s an adverse effect on glycaemia is debatable. This study explored the effect of inhaled fluticasone in long term asthma patients. A comparative cross-sectional study was conducted among the adult normoglycaemic asthma patients in Bangladesh between June 2017 to May 2018. The study groups were getting inhaled fluticasone for a minimum of three months whereas comparative group were not on any steroids. Each group had 35 eligible participants. Results: In study group, mean plasma glucose at fasting was 5.27 ± 0.48 mmol/L, 2-hour after 75gm oral glucose was 6.04 ± 1.21 mmol/L and mean of HbA1c was 5.57 ± 0.41 % whereas in comparative group these were 5.17 ± 0.59 mmol/L, 5.69 ± 1.09 mmol/L, 5.47 ± 0.40 % respectively (p= 0.25, 0.20, 0.75 respectively). Duration of inhaled fluticasone use had no specific co-relation with fasting plasma glucose, plasma glucose 2-hour after 75gm oral glucose and HbA1c% (r= 0.016, p= 0.46; r= 0.015, p= 0.47; r= 0.019, p= 0.42 respectively).

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Assessment of inhaled corticosteroids use and associated factors among asthmatic patients attending Tikur Anbessa Specialized Hospital, Ethiopia

Cited by 10 publications

References 18 publications

Non-adherence to inhaled medications among adult asthmatic patients in Ethiopia: a systematic review and meta-analysis

Non-adherence to inhaled medications among adult asthmatic patients in Ethiopia: a systematic review and meta-analysis

Assessment of Asthma Control and Quality of Life among Asthmatic Patients Attending Armed Forces Referral and Teaching Hospital, Addis Ababa, Ethiopia

Plasma Glucose Levels of Asthma Patients Using Inhaled Fluticasone

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