Assessment of Integrated Antioxidant Systems and Hormezis Effect of Radon in Experimental Studies

Nikolaishvili, Marine; Nanobashvili, Zaqaria; Mitagvaria, Nodar; Chkadua, Gvantsa; Museliani, Tea; Dondoladze, Khatuna; Jikia, Gogi

doi:10.4236/jbm.2022.103020

Cited by 4 publications

(9 citation statements)

References 21 publications

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“…Because such methods are characterized by fewer side effects and, therefore, if chronic use is necessary, they cause less harm to a person. The method of treatment with Tskhaltubo water is a type of drug that has passed the basic phase of research on experimental models of epilepsy, which corresponds to the experimental research phase defined for studying the effectiveness of drug methodologies [7], [16], [20], [21], [23].…”

Section: Discussionmentioning

confidence: 99%

“…They are predisposed to audiogenic epilepsy (seizures in response to a strong sound). Rapid (5-7 s) development of clonic-tonic seizures and the development of postictal catalepsy are characteristic of KM rats [7], [12], [16], [25].…”

Section: Methodsmentioning

confidence: 99%

“…Long-term (15 min) exposure of KM rats to the action of sound according to a special scheme with alternating 10 s periods of strong and weak sound causes cerebral circulation disorders in them, externally manifested in the form of paresis and paralysis of the limbs. On the 10 th days and 3 months assessment of epileptic seizure with trigger -sound in BK rats was performed [7], [12], [16], [18], [20], [21], [22], [23], [25].…”

Section: Epileptic Seizuresmentioning

confidence: 99%

“…All named measurements were provided by means of Photometric Analytical System FRAS 5 (H&D, Parma, Italy) [2], [7], [16], [21], [23].…”

Section: Laboratory Examinationmentioning

confidence: 99%

“…Disorder of the functioning of mitochondria during epileptic seizures is inevitably accompanied by an increased generation of ROS [5], [6]. The OS markers in the brain after seizures were observed both in animal models of epilepsy and in patients with epilepsy [7]. The most important consequence of the accumulation of ROS in epilepsy is the excessive and uncontrolled activation of lipid peroxidation (LPO) processes under these conditions.…”

Section: Introductionmentioning

confidence: 99%

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The Level of Individual Biochemical Constants of the Brain of in the Krushinsky-Molodkina Inbred Rat Strain against the Background of Radon Inhalation During Epilepsy

Nikolaishvili¹,

Nanobashvili²,

Mitagvaria³

et al. 2022

Open Access Maced J Med Sci

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Introduction: The elucidation of the mechanism of action of radon on antioxidant processes needs further research, however, based on the results of the experiment, it can be concluded that studies on experimental animals have shown that, while inhaling Tskhaltubo water, the phenomenon of hormesis develops. Methods: we placed 10 experimental animals (KM rats) in Radon contained mineral water spa`s sauna. Inhalation of radon-water was administered through the nose, for 10 minutes, once a day, in conditions of high humidity (about 90%) for 10 days. Results: Hormesis regulates oxidative processes in the brain due to the activation of antioxidants expressed in a decrease in existing epileptic seizures and is expressed in the activation of Na / K-ATPase and specific glutaminergic neurons of the "attack center" of the hypothalamus but also with the activation of the entire adaptive-compensatory system. Conclusion: Inhalation of radon contained water can be considered as a method of treatment with an anticonvulsant effect confirmed by experimental studies.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Epileptic Seizuresmentioning

confidence: 99%

“…All named measurements were provided by means of Photometric Analytical System FRAS 5 (H&D, Parma, Italy) [2], [7], [16], [21], [23].…”

Section: Laboratory Examinationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Level of Individual Biochemical Constants of the Brain of in the Krushinsky-Molodkina Inbred Rat Strain against the Background of Radon Inhalation During Epilepsy

Nikolaishvili¹,

Nanobashvili²,

Mitagvaria³

et al. 2022

Open Access Maced J Med Sci

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Exposure to Hyaluronan and Radon-Containing Water during the Treatment of Periodontal Pockets

Gibishvili,

Gogiberidze,

Nikolaishvili

2023

JBM

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Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature underscores the significance of HA in maintaining tissue water balance, fostering cell proliferation, promoting rapid cell migration, influencing cell differentiation during organism development, and facilitating tissue regeneration. Notably, HA's interactions with cell surface receptors contribute to the viscosity of synovial fluid, activate the immune system, and enhance cartilage elasticity. Beyond these established functions, HA has also been investigated for its potential involvement in determining and studying the hormetic effects of radon water, adding a novel dimension to its applications in dental research. A thorough exploration of existing studies reveals a nuanced understanding of how HA interventions impact the outcomes of dental procedures. The comprehensive scope of these investigations allows for a more accurate assessment of the potential effectiveness of specific interventions and provides valuable insights into post-procedural prognoses for individual patients. This synthesis of literature serves as the foundation for elucidating the intricate interplay between HA, radon exposure, and their relevance in modern dental practices.

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Effects of Inhalation of Low Doses of Radon in the Krushinsky-Molodkina Rat Strain and Study of Various Behavioral Characteristics

NIKOLAISVILI,

NANOBASHVILI,

MITAGVARIA

et al. 2023

jecm

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To study the effect of radon in balneotherapy, a group of experimental animals (multiple low doses in KM and epileptic Wistar rats were used) went through the procedure of inhalation of radon by the Tskaltubo mineral water pool, once daily, during 20 min, 10 days. In animals of the control groups, inhalation with radon was not used. After radon inhalation therapy with Tskaltubo mineral water, it was analyzed the absence or reduction of epileptic seizures.This research showed that Tskaltubo mineral water radon inhalation caused hormesis, absence or reduction of epileptic seizures. The result was stable during 6-12 months. Stabilization positively influenced oxidative stress levels, Na/K-ATF in epileptic rats. The result of our experiment gives us a stimulus to continue future research to find more specific neurochemical mechanisms participating in radon hormesis processes.Oxidative stress resulting from excessive free-radical release is likely implicated in the initiation and progression of epilepsy. An increase in active forms of oxygen or free radicals of oxygen is believed to play an important role in epileptic rats. To investigate the relationship between oxidative stress and memory impairment in epileptic mice, we determined the level of activity of antioxidant enzymes in blood plasma. The results showed that the level of lipid peroxidation in the plasma was significantly higher in epileptic rats than in control Wistar rats. Therefore, our study aimed to investigate the effects of radon inhalation on different forms of behavior in epileptic rats, both to positive and negative stimuli. As known from the literature, antioxidant therapies aimed at reducing oxidative stress have received considerable attention in epilepsy treatment. This article discusses various forms of behavior in KM rats as revealed by experiments. The KM rat strain differs from the Wistar rat strain in the nature of the locomotor activity, a higher level of exploratory activity, and increased emotionality. For rats of the KM rat strain, instability of behavioral reactions is characteristic, which manifests itself in all areas of their activity in the "open field" test. As for memory in epileptic rats, the behavior based on negative stimuli is not impaired in their psycho-neurological memory. Conditioned-reflex behavior developed on a positive stimulus, which we studied in a trestle-type maze, the obtained results showed that 10 epileptic rats complete the exit of this maze in 1 minute, already after 7 days without error. We have studied three sections of social environment awareness. It was determined that the time (p<0.001) and the number of contacts (p<0.001) were statistically significantly reduced among КM male rats. Decrease in indicators of social interaction: Group KM reliably spent less time in the compartment with animals (р<0.01) and spent more time near its cell. As a result of movement in the crossmaze, it was determined that KM rats spent more time in the closed arm, had more interrupted and rotated (tail-to-front) grooming than...

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Assessment of Integrated Antioxidant Systems and Hormezis Effect of Radon in Experimental Studies

Cited by 4 publications

References 21 publications

The Level of Individual Biochemical Constants of the Brain of in the Krushinsky-Molodkina Inbred Rat Strain against the Background of Radon Inhalation During Epilepsy

The Level of Individual Biochemical Constants of the Brain of in the Krushinsky-Molodkina Inbred Rat Strain against the Background of Radon Inhalation During Epilepsy

Exposure to Hyaluronan and Radon-Containing Water during the Treatment of Periodontal Pockets

Effects of Inhalation of Low Doses of Radon in the Krushinsky-Molodkina Rat Strain and Study of Various Behavioral Characteristics

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