The article examines the impact of environmental pollution factors on life expectancy in Uzbekistan. The study is based on econometric modeling methods, including panel data on the country’s regions for the period of 2010-2023. The area of protected natural areas, the volume of pollutant emissions into the atmosphere, the provision of doctors and hospital beds, and access to drinking water were utilized as factors influencing life expectancy. Despite the identification of some relationships, the modeling results showed limited explanatory power of the selected models, which is associated with the low quality and incompleteness of statistical data. The study revealed significant regional differentiation and polarization in environmental indicators, which requires measures to improve the quality of data and take into account additional factors.