Assessment of Intrauterine Methylmercury Exposure Affecting Child Development: Messages from the Newborn

Murata, Katsuyuki; Dakeishi, Miwako; Shimada, Maki; Satoh, Hiroshi

doi:10.1620/tjem.213.187

Cited by 34 publications

(22 citation statements)

References 68 publications

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“…The main sources of lead exposure in American children were floor lead loading, poor housing conditions, paint chip ingestion, and soil ingestion 86) , and the mean BPb level from infants to schoolchildren decreased gradually [87][88][89][90] . Neurological disorders may not arise if the timing between the most susceptible period of the brain and the peak exposure of lead are subtly different 91) . In this sense, the findings of Jusko et al 6) would be implicative for the assessment of lead neruotoxicity in children because the exposure level at less than 2 yr of age has been suggested to be of great importance.…”

Section: Recent Perspective On Lead Toxicity In Childrenmentioning

confidence: 99%

Lead Toxicity: Does the Critical Level of Lead Resulting in Adverse Effects Differ between Adults and Children?

Murata

Iwata

Dakeishi

et al. 2009

Journal of Occupational Health

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µg/dl for industrial workers and 5 µg/dl for children. To examine whether the critical level of lead producing adverse effects truly differs between workers and children, we provided an overview of studies addressing the critical level of lead in workers, together with a perspective on lead toxicity in children. Data sources and extraction: In 25 reports published in English with keywords of "benchmark dose (BMD)," "lead" and "humans," only five studies proved to be relevant to lead toxicity. Four more studies with figures illustrating significant relationships between lead and neurotoxic outcomes were selected. Data synthesis: Based on data from previous reports using a BMD approach, the critical organ of lead in workers was thought to be the nervous system and the critical BPb level (numberweighted mean) was between 10.7 and 17.5 µg/dl. The neurotoxic effects of lead exposure at such levels seemed reversible. The BPb level at which leadassociated intellectual deficits occurred in children was as low as the critical level of BPb (below 5 µg/dl) for inhibited heme synthesis in workers. Conclusions: The neurotoxic effects of lead in workers appear to be initiated at BPb levels below 18 µg/dl, which are somewhat higher than the critical level of lead neurotoxicity in children. Each national institute for risk Review management should take evidence-based preventive action against subclinical lead poisoning in workers, as well as in children. (J Occup Health 2009; 51: 1-12)

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Section: Recent Perspective On Lead Toxicity In Childrenmentioning

confidence: 99%

Lead Toxicity: Does the Critical Level of Lead Resulting in Adverse Effects Differ between Adults and Children?

Murata

Iwata

Dakeishi

et al. 2009

Journal of Occupational Health

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“…The study of associations between inorganic chemical exposures during pregnancy and adverse child neuro-developmental outcomes has focused on inorganic lead (Pb) and organic mercury (Hg), although childhood exposure to arsenic (As) has also been shown to negatively impact neurological development of children (Filley and Kelly, 2001; Canfield et at., 2003; Goldman and Koduru, 2000; Wasserman et al, 2004; Factor-Litvak et al, 1999; Murata et al, 2007; Rosado et al, 2007). …”

Section: Introductionmentioning

confidence: 99%

The relationship between mental retardation and developmental delays in children and the levels of arsenic, mercury and lead in soil samples taken near their mother’s residence during pregnancy

Liu

McDermott

Lawson

et al. 2010

International Journal of Hygiene and Environmental Health

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This study was designed to evaluate the association between lead, mercury, and arsenic in the soil near maternal residences during pregnancy and mental retardation or developmental disability (MR/DD) in children. The study was conducted using 6,048 mothers who did not move throughout their pregnancies and lived within six strips of land in South Carolina and were insured by Medicaid between January 1, 1997 and December 31, 2002. The mother child pairs were then followed until June 1, 2008, through their Medicaid reimbursement files, to identify children diagnosed with MR/DD. The soil was sampled for mercury (Hg), lead (Pb), and As based on a uniform grid, and the soil concentrations were Kriged to estimate chemical concentration at individual locations. We identified a significant relationship between MR/DD and As, and the form of the relationship was nonlinear, after controlling for other known risk factors.

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“…In an analysis of total mercury levels in cord blood and maternal blood samples in 28 international studies, Murata et al 18 cited levels ranging from 0.96µg/L in 1,109 individuals in Canada in a study by Rhainds et al 19 to 22.35µg/L reported by Grandjean et al 20 in 996 subjects in the Faroe Islands. Taking the previously cited values as the reference, or 8.0µg/L for total blood mercury in unexposed individuals or up to 5.8µg/L as suggested by Mahaffey et al 21 , the cord blood levels detected in the current study were high.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal assessment of mercury exposure in schoolchildren in an urban area of the Brazilian Amazon

et al. 2012

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This study was a longitudinal assessment of mercury exposure in schoolchildren in an urban area of the Brazilian Amazon. The study population consisted of 90 children whose exposure levels were assessed by testing mercury levels in the umbilical cord blood and mothers' blood samples in 2000-2001, and in the children's hair and blood samples. The study also used a questionnaire on demographic and socioeconomic data, fish consumption, and self-reported disease history. Mean mercury level in hair in 2010 was approximately 1µg/g, ranging up to 8.22µg/g, similar to 2004 and 2006. These figures can be explained by low fish consumption. Mean blood mercury levels at birth exceeded 10µg/L, ranging up to nearly 60µg/L, which indicates mercury transfer across the placenta. There was a significant increase in blood mercury from 2004 to 2006 (p < 0.001), suggesting exposure through air pollution. The main exposure to mercury was during pregnancy.

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Assessment of Intrauterine Methylmercury Exposure Affecting Child Development: Messages from the Newborn

Cited by 34 publications

References 68 publications

Lead Toxicity: Does the Critical Level of Lead Resulting in Adverse Effects Differ between Adults and Children?

Lead Toxicity: Does the Critical Level of Lead Resulting in Adverse Effects Differ between Adults and Children?

The relationship between mental retardation and developmental delays in children and the levels of arsenic, mercury and lead in soil samples taken near their mother’s residence during pregnancy

Longitudinal assessment of mercury exposure in schoolchildren in an urban area of the Brazilian Amazon

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