Assessment of iron status in regular blood donors in a tertiary care hospital in Southern India

Basavarajegowda, Abhishekh; Anju, Joy; Basu, Debdatta; Bobby, Zachariah; Murali, Sharan

doi:10.4103/ajts.ajts_119_21

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…Data was not sufficient to perform subgroup analysis for age or gender ratio, since most of the studies reported the age range of the enrolled subjects rather than data for specific age groups or specific gender. Apart from the testing method, the high heterogeneity could be attributed to population–specific genetic factors, iron status, gender, and other social and behavioural factors that might influence serum ferritin levels 63–66 . Significant publication bias was also observed for all four comparisons.…”

Section: Discussionmentioning

confidence: 99%

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Serum ferritin level as a prognostic biomarker for predicting dengue disease severity: A systematic review and meta‐analysis

Shukla

Jadhav

Gurav

et al. 2023

Reviews in Medical Virology

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Serum ferritin levels serves as biomarkers in many inflammatory and infectious diseases. This current systematic review and meta‐analysis evaluated whether serum ferritin levels are associated with severe dengue and its utility as a biomarker of disease severity. Literature searches were conducted in PubMed, Scopus, ScienceDirect, the Cochrane library, and Google Scholar. A total of 18 studies examining the serum ferritin levels in dengue cases in the context of disease severity (nine studies having dengue classification as non‐severe vs. severe dengue cases, and nine studies having dengue classification as dengue without warning signs (DwoWS), dengue with warning signs (DwWS), and severe dengue cases) were included and the quality of the studies was assessed using the Quality in Prognostic Factor Studies tool. The meta‐analysis was performed using STATA software to calculate the effect size as a standardized mean difference (SMD) or Hedges ‘g’ for the continuous outcome. Higher serum ferritin levels were found in severe dengue cases compared to non‐severe cases [SMD (Hedges ‘g’) 4.05 (95% C.I. 2.09–6.00), (I2 = 98.8%)]. In the second group, DwWS cases showed high serum ferritin levels compared to DwoWS [SMD 2.01 (95% C.I. 0.92–3.10), (I2 = 97.89%)], and severe dengue cases showed higher levels of serum ferritin compared to DwWS [SMD 2.66 (95% C.I. 1.72–4.48), (I2 = 98.78%)] and DwoWS cases [SMD 6.65 (95% C.I. 1.72–11.59), (I2 = 99.78%]. Subgroup analysis for the country of study (India vs. others), ferritin testing methods, and ferritin measurement day revealed testing method as a significant contributor to heterogeneity. To conclude, the present study suggests serum ferritin as a prognostic marker for dengue disease severity. Multi‐centric studies involving a large number of dengue patients with a uniform case definition accounting for all the confounding variables might help in determining a universal cut‐off value to discriminate between non‐severe and severe dengue.

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Section: Discussionmentioning

confidence: 99%

“…Apart from the testing method, the high heterogeneity could be attributed to population-specific genetic factors, iron status, gender, and other social and behavioural factors that might influence serum ferritin levels. [63][64][65][66] Significant publication bias was also observed for all four comparisons. SHUKLA ET AL.…”

Section: Discussionmentioning

confidence: 99%

Serum ferritin level as a prognostic biomarker for predicting dengue disease severity: A systematic review and meta‐analysis

Shukla

Jadhav

Gurav

et al. 2023

Reviews in Medical Virology

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“…Iron defciency in blood donors is a global problem [3,8,[14][15][16][17][18][19]. Te frequency found in our series, of 16.66%, seems low compared to those reported in Africa: 17.5% in a large population of nearly 4,500 blood donors in South Africa [15], 20.6% in Nigeria [16], just over a quarter (27.4%) in Ghana [10], 35.2% in Algeria [9], or 63% in the DRC [8] to name but a few.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Iron Deficiency, Anemia, and Associated Factors in a Blood Donor Population in Brazzaville, Congo

Galiba Atipo-Tsiba,

Gayaba Mouyabi,

Angounda

et al. 2023

Anemia

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Introduction. Blood donation is not without risk to the donor. It results in a substantial loss of iron and decreased hemoglobin. In our country, no predonation assessment is carried out and the selection of blood donors is only clinical. Objectives. To determine the prevalence of iron deficiency, anemia, and iron deficiency anemia and to identify the factors associated with anemia and iron status in a blood donor population at the National Center for Blood Transfusion (NCBT). Methodology. A prospective study is carried out that consists of 120 blood donors in three NCBT branches in the capital from June to November 2021. The donors were divided into 3 groups: first time donors (FTDs), occasional donors (ODs) who have already made between 1 and 3 previous donations, and regular donors (RDs) with at least 4 previous donations. Iron deficiency was defined by a serum ferritin value of less than 30 ng/mL in men and 20 ng/mL in women. Anemia was defined by Hb levels below 13 g/dL in men and 12 g/dL in women. Iron deficiency anemia was defined by association of anemia and iron deficiency. The chi-square test was used for the comparison of the proportions. The odds ratio with the 95% confidence interval was calculated to assess the association between two variables. The p value of the probability was considered significant for a value < 0.05. Results. Mean serum ferritin and hemoglobin values were lower in RD in both sexes. The prevalence of iron deficiency, anemia, and iron deficiency anemia were 16.66%, 31.66%, and 10.83%, respectively. The factors associated with the three abnormalities were female sex, donor type, including RD, and number of previous donations. Conclusion. Iron deficiency, anemia, and iron deficiency anemia are common among blood donors in Brazzaville. Anemia affects almost a third of blood donors and is not always linked to iron deficiency. Safety of donors should be improved by systematic measurement of ferritinemia and hemoglobin levels before allowing donations for appropriate management in the event of abnormalities.

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Impact of iron supplementation among anemic voluntary first‐time blood donors: Results from the BLOODSAFE pilot trial in Ghana

Dei‐Adomakoh,

Olayemi,

Telke

et al. 2024

Transfusion

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IntroductionIn sub‐Saharan Africa (SSA), an adequate supply of safe blood for transfusion is a major developmental challenge. In Ghana, deferral from blood donation for anemia accounts for nearly half of the ineligible blood donors. We conducted a longitudinal two‐arm parallel‐group non‐inferiority trial to test if iron supplementation among blood donors with iron deficiency (ID) or anemia could increase their hemoglobin levels to near those without ID or anemia.Materials and MethodsA structured questionnaire was used to collect participants' sociodemographic and medical information after written informed consent was obtained. Blood samples were analyzed for full blood count (FBC), serum ferritin, malaria rapid test, and a peripheral blood smear. The primary outcome was hemoglobin level after 4 months comparing anemic donors who received iron supplementation to the standard of care participants, nonanemic donors who did not receive iron supplementation. All donors received nutritional counseling.ResultsAdherence to low‐dose iron supplementation three times a week was poor. Hemoglobin levels in the iron supplementation arm were not close enough to those in the control group after 4 months of iron supplementation to declare non‐inferiority. However, non‐inferiority was met when the 4 month hemoglobin comparison was restricted to female donors.ConclusionAfter 4 months of iron supplementation, hemoglobin levels in the iron supplementation group did not sufficiently match those in the control group to declare non‐inferiority. Data from this pilot trial informed and shaped the design of a larger randomized control type 1 pragmatic effectiveness implementation hybrid trial which is currently ongoing.

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Assessment of iron status in regular blood donors in a tertiary care hospital in Southern India

Cited by 3 publications

References 31 publications

Serum ferritin level as a prognostic biomarker for predicting dengue disease severity: A systematic review and meta‐analysis

Serum ferritin level as a prognostic biomarker for predicting dengue disease severity: A systematic review and meta‐analysis

Prevalence of Iron Deficiency, Anemia, and Associated Factors in a Blood Donor Population in Brazzaville, Congo

Impact of iron supplementation among anemic voluntary first‐time blood donors: Results from the BLOODSAFE pilot trial in Ghana

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