Assessment of ischemia reperfusion injury in skeletal muscle by macromolecular clearance

Suval, William D.; Hobson, Robert W.; Borić, Mauricio P.; Ritter, Arthur; Durán, Walter N.

doi:10.1016/0022-4804(87)90031-x

Cited by 36 publications

(14 citation statements)

References 11 publications

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“…One may further speculate that there is a cause-and-effect relationship between the endothelial protective effect and prevention of the so-called 'no-reflow' phenomenon exhibited by danshen, while endothelial cells are likely to be more important sites and targets of oxygen radical damage than the skeletal muscle. The earliest changes noted following an ischemic insult in skeletal muscle involved a breakdown of endothelial integrity with an increase in microvascular permeability (21). These changes precede structural alterations in the muscle cell (22).…”

Section: Discussionmentioning

confidence: 99%

Effect of the extract from salvia miltiorrhiza radix (SMR) on skeletal muscle ischemia and reperfusion injury in rabbits

Yang¹,

Morris²

1997

CAN J PLAST SURG

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T he development of microsurgical techniques for replantation of amputated digits and limbs has led to longer periods of ischemia in the clinical setting. In addition, transplantation of skeletal muscle is employed to treat facial paralysis and Volkmann's ischemic contracture. To restore function to replanted extremities and transplanted muscle, not only should the ischemic period be shorter than that required for successful replantation and transplantation, but also reperfusion injury of skeletal muscle should be avoided. White cell inhibitors, enriched substrates and controlled rates of reperfusion, or combinations of these, have been shown to improve muscle viability and recover potentially viable muscle, oxygen and hydroxyl radical scavengers after prolonged ischemia and variable periods of reperfusion (1-4).Salvia miltiorrhizae radix (Chinese crude drug named 'danshen') has been used in China as a therapeutic modality for The extract of salvia miltiorrhiza radix (SMR) is a well known Chinese herbal medicine known as danshen. It has been found in several experimental studies, published mostly in China, to have antioxidant properties. The purpose of this experiment was, therefore, to compare the effects of danshen injection with those of superoxide dismutase (SOD) and mannitol on skeletal muscle ischemia and reperfusion injury in rabbits. The authors used a rabbit limb replantation model subjected to 5 h of global ischemia. Immediately before reperfusion, the animals received SOD (16,000 U/kg), mannitol (1 g/kg) or danshen injection (2 g/kg) intravenously. Both danshen and mannitol significantly increased limb survival (P<0.01). Increased limb survival was observed in the SOD-treated group compared with the saline-treated group (P<0.05) but not with the ischemic group (P>0.05). Light and transmission electron microscopy revealed that the pathologic and ultrastructural changes in skeletal muscles, which were subjected to 5 h of ischemia followed by 2 h of reperfusion, were reduced with SOD, mannitol and danshen injection. These results suggest that the hydroxyl radical seems to be the most important factor in ischemia and reperfusion injury to skeletal muscle and that danshen, like mannitol, may have a role in antioxidation as a hydroxyl radical scavenger. Key Words: Antioxidant, Ischemia/reperfusion injury, Rabbit, Salvia miltiorrhiza radixEffet d'un extrait de racine de salvia miltiorrhiza sur l'ischémie du muscle squelettique et la lésion de reperfusion chez le lapin RÉSUMÉ : L'extrait de racine de salvia miltiorrhiza est bien connu comme plante médicinale en Chine, sous le nom de danshen. Selon plusieurs études expérimentales publiées surtout en Chine, cette plante aurait des propriétés antioxydantes. Le but de l'expérience était donc de comparer les effets d'une injection de danshen à ceux de la superoxyde dismutase (SOD) et du mannitol sur l'ischémie du muscle squelettique et sur la lésion de reperfusion chez le lapin. Les auteurs ont utilisé un modèle de réimplantation de membre chez le lapin soumis à ...

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Section: Discussionmentioning

confidence: 99%

Effect of the extract from salvia miltiorrhiza radix (SMR) on skeletal muscle ischemia and reperfusion injury in rabbits

Yang¹,

Morris²

1997

CAN J PLAST SURG

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“…Suval et al, using the increased macromolecular clearance of fluorescein isothiocyanate-dextran 150 (FITC-Dx 150) as a quantitative index of the resulting injury, 25 demonstrated that iv pretreatment with DXM (3 hr before the onset of ischemia and immediately before ischemia at a dose of 5 mg/kg) attenuated the alterations in microvascular Figure 1. Chemical structure of an adrenocortical androgen (testosterone) and a steroid synthetic analog (methylprednisolone) sharing a four-ring nucleus (dotted area).…”

Section: Gcs Attenuate Alterations In Microvascular Permeability In Rmentioning

confidence: 98%

Actions of glucocorticosteroids on ischemic-reperfused muscle and cutaneous tissue

et al. 1996

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Ischemia-reperfusion injury represents a complex series of vascular and cellular events that resembles an acute inflammatory reaction within the reperfused tissue. This article provides an overview of glucocorticosteroid effects on cells and tissues involved in inflammatory reaction following ischemia-reperfusion of muscle and cutaneous tissue. Glucocorticosteroids exert a variety of effects that influence the microcirculation. These effects include leukocyte recruitment, reduction of vascular permeability, inhibition of formation of cytokines or other mediators, and modulation of enzyme systems involved in inflammation. The current view is that glucocorticosteroids act through cytoplasmic receptors by controlling the transcription of certain genes encoding regulatory proteins, but the exact mechanisms of glucocorticoid action on ischemia-reperfusion are not completely understood. Potential mechanisms may involve modulation of neutrophil and endothelial function, inhibition of formation of arachidonic acid products, and attenuation of lipid peroxidation of biological membranes through membrane stabilization and scavenging of toxic free radicals.

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“…Sie beeinträchtigt nachhaltig die Funktion der Extremität, verzögert die Heilung und erschwert die postoperative Mobilisation der Patienten [17]. zyten hatte zugenommen [42]. Die Autoren zeigten, daß diese Phänomene einer Schädigung der Skelettmuskulatur vorausgehen [41].…”

Section: Pathophysiologie Des Ischämie-/ Reperfusionsschadensunclassified

Veränderungen der Flüssigkeitsfiltrationskapazität und des Blutflusses nach Tourniquet bei Knieoperationen in Spinalanästhesie

et al. 1998

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Assessment of ischemia reperfusion injury in skeletal muscle by macromolecular clearance

Cited by 36 publications

References 11 publications

Effect of the extract from salvia miltiorrhiza radix (SMR) on skeletal muscle ischemia and reperfusion injury in rabbits

Effect of the extract from salvia miltiorrhiza radix (SMR) on skeletal muscle ischemia and reperfusion injury in rabbits

Actions of glucocorticosteroids on ischemic-reperfused muscle and cutaneous tissue

Veränderungen der Flüssigkeitsfiltrationskapazität und des Blutflusses nach Tourniquet bei Knieoperationen in Spinalanästhesie

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