2010
DOI: 10.2141/jpsa.009092
|View full text |Cite
|
Sign up to set email alerts
|

Assessment of Key Pharmacokinetic Variables of Bioequivalent and Non-bioequivalent Enrofloxacin Preparations under Various Water Management Conditions

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
5
0

Year Published

2012
2012
2023
2023

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

citations
Cited by 5 publications
(5 citation statements)
references
References 22 publications
0
5
0
Order By: Relevance
“…In addition there may be variable wastage depending on the type and management of drinkers (140,263). Failure to ensure these factors are optimised can lead to ineffective drug delivery, as observed in a study of enrofloxacin in chickens (250,251). Because of the number of factors influencing water intake, it is usually recommended that current water intake is actually measured and used in calculations on dilution rates.…”
Section: Water Medicationmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition there may be variable wastage depending on the type and management of drinkers (140,263). Failure to ensure these factors are optimised can lead to ineffective drug delivery, as observed in a study of enrofloxacin in chickens (250,251). Because of the number of factors influencing water intake, it is usually recommended that current water intake is actually measured and used in calculations on dilution rates.…”
Section: Water Medicationmentioning
confidence: 99%
“…There are few cases published in the veterinary literature, although one report observed a preponderance of fake and/or expired drugs in Nigeria (61) and participants in a WHO consultation suggested that expired products were being relabelled and sold (289). In countries where there is no regulatory requirement to demonstrate bioequivalence, some generic versions of pioneer products have been shown to be of variable quality and to have pharmacokinetic profiles unlikely to be associated with effective antimicrobial activity (250,252).…”
Section: Product Qualitymentioning
confidence: 99%
“…maximum serum concentration (C MAX ) should reach at least 10-12 times the value of the minimal inhibitory concentration (MIC) (C MAX > 10-12 MIC), and the area under the serum concentration vs. time curve (AUC 0-24 )/MIC should be equal to or higher than 125 (AUC/MIC ≥ 125) (10). These ratios are not always accomplished for enrofloxacin due to many factors, such as defective maneuvers to deliver the correct dose (11,12), the lack of bioequivalence of many pharmaceutical preparations (4)(5)(6)(7), and the presence of resistant bacteria to this antimicrobial agent.…”
Section: Introduction Enrofloxacinmentioning
confidence: 99%
“…The correct use of this antibacterial drug requires the achievement of specific pharmacokinetic/pharmacodynamic (PK/PD) ratios to optimize clinical efficacy; that is, the maximum serum concentration (Cmax) should reach 10–12 times the value of the minimal inhibitory concentration ( MIC ) (Cmax > 10–12 MIC ), and the area under the serum concentration vs. time curve ( AUC 0‐24 )/ MIC should be equal or higher than 125 ( AUC / MIC ≥ 125) (Wright et al ., ). These ratios are not always accomplished due to many factors, such as defective maneuvers to deliver the correct dose in broiler chickens (Randall et al ., ; Sumano et al ., ) and due to lack of bioequivalence (Sumano et al ., , , ).…”
Section: Introductionmentioning
confidence: 99%