Assessment of Knowledge about Liver Cirrhosis among Saudi Population

Al-Johani, Jana Jamalaldeen; Aljehani, Saja Mohammad; Alzahrani, Ghaedaa Saad

doi:10.12816/0045639

Cited by 6 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study conducted in Saudi Arabia regarding liver cirrhosis, which is a part of CLD, 54% of Saudi population had good knowledge while 46% had poor knowledge [12]. The most probable reason for majority of their population having good knowledge is the higher literacy rate as compared with that of Pakistan, which supports our results, i.e., majority of the people having poor knowledge.…”

Section: Discussionsupporting

confidence: 84%

Assessment of Knowledge About the Risk Factors of Chronic Liver Disease in Patients Admitted in Civil Hospital Karachi

Majid¹,

Khan²,

Junaid³

et al. 2019

Cureus

View full text Add to dashboard Cite

BackgroundChronic liver disease (CLD) encompasses a series of single or multifactorial insults to the liver, most common of which are hepatitis, alcohol abuse, and non-alcoholic liver disease. CLD represents a major public health problem worldwide as well as in Pakistan. Unfortunately, studies evaluating the awareness of its risk factors among people are quite scarce. The purpose of this study was to assess the knowledge about risk factors of CLD in patients admitted to Dr. Ruth K M Pfau, Civil Hospital Karachi (CHK).MethodsThis quantitative cross-sectional study was conducted at CHK, among 368 patients admitted to CHK, during the period from February 2018 to September 2018. Frequencies and percentages were evaluated for categorical variables using Statistical Package for Social Sciences (SPSS), version 22 (IBM Corp., Armonk, NY). Chi-square test was applied to determine if there was any significant association between the variables. A p-value of <0.05 was considered significant.ResultsA scoring scale was developed to assess the level of knowledge. We found that only 32% of our study population had good knowledge about the risk factors of CLD while majority of them (68%) had poor knowledge. Regarding individual risk factors, >60% patients were aware that obesity, high fat intake, prolonged use of drugs, use of alcohol and hepatitis B and C are risk factors of CLD, while most of them did not know diabetes to be a risk factor as well. 51.4% patients thought that hepatitis B and C could not be transmitted via sexual contact and from mother to her baby. There was a positive association between education level and awareness about the risk factors of CLD (p = 0.006).ConclusionFuture interventions to increase public awareness about CLD should promptly be taken. The lack of knowledge about this disease is the main cause of its rapid increment and the reason why it is so prevalent in our part of the world especially Pakistan. More studies and nationwide awareness programs are needed to control its spread.

show abstract

Section: Discussionsupporting

confidence: 84%

Assessment of Knowledge About the Risk Factors of Chronic Liver Disease in Patients Admitted in Civil Hospital Karachi

Majid¹,

Khan²,

Junaid³

et al. 2019

Cureus

View full text Add to dashboard Cite

show abstract

“…In the middle-eastern regions, nearly 10% of the population suffers from the infections of hepatitis-B virus (HBV), and more than 2% of the population is infected with the hepatitis-C virus (HCV), which indicates high prevalence rates of these liver-related infections, which is in addition to other liver-based disorders, including the symptomatic conditions of hyperbilirubinemia-related yellow-coloration, commonly referred to as jaundice. Liver disorders are a serious global healthcare concern [ 2 ], and the demand for valuable health-care resources, as well as attention in curtailing them, is huge [ 3 , 4 ]. The common risk factors, such as obesity, diabetes, hypercholesterolemia, and excessive drinking also make the situation further alarming [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Suaeda vermiculata Aqueous-Ethanolic Extract-Based Mitigation of CCl4-Induced Hepatotoxicity in Rats, and HepG-2 and HepG-2/ADR Cell-Lines-Based Cytotoxicity Evaluations

Mohammed

Khan

El-Readi

et al. 2020

Plants

View full text Add to dashboard Cite

Suaeda vermiculata, an edible halophytic plant, used by desert nomads to treat jaundice, was investigated for its hepatoprotective bioactivity and safety profile on its mother liquor aqueous-ethanolic extract. Upon LC-MS (Liquid Chromatography-Mass Spectrometry) analysis, the presence of several constituents including three major flavonoids, namely quercetin, quercetin-3-O-rutinoside, and kaempferol-O-(acetyl)-hexoside-pentoside were confirmed. The aqueous-ethanolic extract, rich in antioxidants, quenched the DPPH (1,1-diphenyl-2-picrylhydrazyl) radicals, and also showed noticeable levels of radical scavenging capacity in ABTS (2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid) assay. For the hepatoprotective activity confirmation, the male rat groups were fed daily, for 7 days (n = 8/group, p.o.), either carboxyl methylcellulose (CMC) 0.5%, silymarin 200 mg/kg, the aqueous-ethanolic extract of the plant Suaeda vermiculata (100, 250, and 500 mg/kg extract), or quercetin (100 mg/kg) alone, and on day 7 of the administrations, all the animal groups, excluding a naïve (250 mg/kg aqueous-ethanolic extract-fed), and an intact animal group were induced hepatotoxicity by intraperitoneally administering carbon tetrachloride (CCl4). All the animals were sacrificed after 24 h, and aspartate transaminase and alanine transaminase serum levels were observed, which were noted to be significantly decreased for the aqueous-ethanolic extract, silymarin, and quercetin-fed groups in comparison to the CMC-fed group (p < 0.0001). No noticeable adverse effects were observed on the liver, kidney, or heart’s functions of the naïve (250 mg/kg) group. The aqueous-ethanolic extract was found to be safe in the acute toxicity (5 g/kg) test and showed hepatoprotection and safety at higher doses. Further upon, the cytotoxicity testings in HepG-2 and HepG-2/ADR (Adriamycin resistant) cell-lines were also investigated, and the IC50 values were recorded at 56.19±2.55 µg/mL, and 78.40±0.32 µg/mL (p < 0.001, Relative Resistance RR 1.39), respectively, while the doxorubicin (Adriamycin) IC50 values were found to be 1.3±0.064, and 4.77±1.05 µg/mL (p < 0.001, RR 3.67), respectively. The HepG-2/ADR cell-lines when tested in a combination of the aqueous-ethanolic extract with doxorubicin, a significant reversal in the doxorubicin’s IC50 value by 2.77 folds (p < 0.001, CI = 0.56) was noted as compared to the cytotoxicity test where the extract was absent. The mode of action for the reversal was determined to be synergistic in nature indicating the role of the aqueous-ethanolic extract.

show abstract

“…Max van Manen (1990) also marked that Phenomenology as a reply to one how orients to lived experience and the question the way to one experiences the world [29]. One of the study reported that 72.2% affected people had college degree [14] but another study mentioned that 67.5% of patients had at least high school degree [31]. In this study, 55% patients have similar educational qualification.…”

Section: Discussionmentioning

confidence: 63%

“…On the other hand, one qualitative study was conducted among community people in Saudi Arabia, they were not patients but they had good knowledge regarding the meaning or definition of the Cirrhosis of liver. Because most of them were higher educated [14]. Open Journal of Gastroenterology…”

Section: Socio-demographic Characteristics Of Cirrhosis Of Livermentioning

confidence: 99%

See 1 more Smart Citation

Lived Experience with Cirrhosis of Liver Patient at a University Hospital: A Qualitative Study

Jannat¹,

Anowar²,

Islam³

et al. 2020

OJGas

View full text Add to dashboard Cite

Introduction: Patients' physical, psychosocial, economical, spiritual and daily activities as well as quality of life are mostly affected by the cirrhosis of liver. It is an advanced stage of liver fibrosis that mostly caused by hepatitis B and hepatitis C, and alcoholism. Objective: This study is intended to explore the lived experience of the patient's with cirrhosis of liver patients. Methodology: A Phenomenological study design was used as a research methodology to elicit in-depth understanding of lived experience of the hospitalized adult cirrhosis of liver patients at

show abstract

Assessment of Knowledge about Liver Cirrhosis among Saudi Population

Cited by 6 publications

References 11 publications

Assessment of Knowledge About the Risk Factors of Chronic Liver Disease in Patients Admitted in Civil Hospital Karachi

Assessment of Knowledge About the Risk Factors of Chronic Liver Disease in Patients Admitted in Civil Hospital Karachi

Suaeda vermiculata Aqueous-Ethanolic Extract-Based Mitigation of CCl4-Induced Hepatotoxicity in Rats, and HepG-2 and HepG-2/ADR Cell-Lines-Based Cytotoxicity Evaluations

Lived Experience with Cirrhosis of Liver Patient at a University Hospital: A Qualitative Study

Contact Info

Product

Resources

About