BackgroundPostpartum hemorrhage (PPH) is one of the leading causes of maternal mortality in sub‐Saharan Africa. Implementing active management in the third stage of labor has significantly reduced the incidence of PPH. Thus, understanding the level of healthcare providers' knowledge of active management in the third stage of labor can inform guidelines, policies, and practices for effectively preventing PPH.ObjectiveThis review aimed to assess the level of healthcare providers' knowledge and associated factors of active management in the third stage of labor in sub‐Saharan Africa.Search StrategyWe conducted a search using PubMed, Scopus, Web of Science, Google Scholar, Cochrane Library, and the African Journals online international databases.Selection CriteriaThe inclusion criteria were determined before the review of the articles and adhere to the criteria of population, intervention, comparison, and outcome.Data Collection and AnalysisStatistical analysis was performed using STATA data analysis software version 14, while Microsoft Excel was utilized for data abstraction. We checked publication bias using a funnel plot and Egger and Begg regression tests. A P value less than 0.05 was considered statistically significant, suggesting the presence of presence publication bias. The I2 statistic was used to assess heterogeneity between studies. The study's overall effect was evaluated using the random effects model.Main ResultThe study included 20 studies to conduct a pooled prevalence analysis. The overall prevalence of healthcare providers' knowledge of active management of third‐stage labor in sub‐Saharan Africa was 47.975% (95% CI: 32.585, 63.365). Having pre‐ and in‐service training (AOR: 2.25, 95% CI: 1.00, 5.08), having a higher degree (AOR: 1.98, 95% CI: 1.39, 2.82), and having good practices (AOR: 8.91, 95% CI: 4.58, 17.40) were significantly associated with healthcare provider's knowledge regarding active management third stage of labor.ConclusionsThe overall healthcare providers' knowledge of active management of the third stage of labor (AMTSL) was low in sub‐Saharan Africa. Obstetric healthcare providers should undertake comprehensive training covering all AMTSL components through pre‐ and in‐service diploma training programs.