Background: Global evidences show that all pregnancies are at risk and complications during pregnancy, childbirth, and the postnatal period are difficult to predict. Awareness regarding puerperal danger signs is essential for appropriate and timely health management so that maternal mortality and morbidity can be reduced. An objective of the study is to assess the awareness and practice regarding puerperal danger signs among postnatal mothers. Method: Descriptive cross-sectional study design was conducted among 139 postnatal mothers, who were attending at maternal and child health (MCH) clinic and postnatal ward of Karnali Academy of Health Sciences (KAHS), Jumla. Probability simple random sampling method was used. Data were collected by using semi-structured interview questionnaire. After collection of the data, coding was done. Coded data was entered into EXCEL and transformed in SPSS for analysis. Result: Out of 139 postnatal mothers, 60.4% had poor level of awareness regarding puerperal danger signs. Only 39.6% had good level of awareness regarding puerperal danger signs. Similarly, 85.6% of the respondents had poor practice on puerperal danger signs. Only 14.4% had good practice on puerperal danger signs. Conclusion: Health education & awareness program is needed to improve the mother’s knowledge and practice on puerperal danger signs.