Assessment of Lead Toxicity in Traffic Controllers of Alexandria, Egypt, Road Intersections

Ahmed, Nageen; El‐Gendy, K.S.; ElRefaie, A. K. A.; Marzouk, S.A.; Bakry, N.S.; El‐Sebae, A. H.; Soliman, S. A.

doi:10.1080/00039896.1987.9935802

Cited by 24 publications

(7 citation statements)

References 4 publications

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“…Many adverse environmental exposures exist in Egypt and may add important elements to the gene-environment interaction in early-onset colorectal cancer in this population. These exposures are the extensive air pollution (50) Esophagus (Ahmed et al, 1987;Anwar 1994) in large cities such as Cairo, chemical pollution of the Nile water with industrial and chemical wastes (Badawy et al, 1995;El-Dib and Badawy, 1985;El-Gendy et al, 1991), extensive use and human exposure to pesticides (Soliman et al, 1997c) and the prevalent intestinal infection with Schistosoma mansoni. In our study, 7 of the families show distal occurrence of colorectal tumors and some extracolonic malignancies do not have a well recognized association with HNPCC such as urinary bladder, prostate, larynx and bone cancers (Lynch and Smyrk, 1996;Mecklin and Jarvinen, 1991;Watson and Lynch, 1993).…”

Section: Discussionmentioning

confidence: 99%

Familial aggregation of colorectal cancer in Egypt

et al. 1998

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We have investigated the familial aggregation of colorectal cancer and hereditary nonpolyposis colorectal cancer (HNPCC) in Egypt because of the high incidence of colorectal cancer in Egyptian children and young adults and the prevalence of consanguinity there. In a pilot study, we conducted detailed interviews with 111 Egyptian colorectal cancer patients and 111 healthy Egyptian controls about their family histories of colorectal cancer, and other cancers, consanguinity, age at diagnosis, symptoms and recurrence. Eight patients (7.2%) had one or more first‐ or second‐degree relatives under age 40 with colorectal cancer, suggestive of HNPCC by the Amsterdam criteria. One of these families had a typical history of HNPCC, with 4 relatives having colorectal cancer in 3 generations; 3 of these relatives were younger than age 45 at colon cancer diagnosis, and other relatives had extracolonic tumors. Another 14 patients (12.6%) had a first‐ or second‐degree relative with a family history of other neoplasms such as endometrial, urinary and hepatobiliary cancers that could also be related to HNPCC. Four patients with early‐onset colon cancer and a family history of other HNPCC‐related cancers reported that their parents were first‐degree cousins. Int. J. Cancer 77:811–816, 1998.© 1998 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Familial aggregation of colorectal cancer in Egypt

et al. 1998

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“…Among the traffic police, the blood lead levels were higher than the acceptable limit, which was also demonstrated by the presence of delta-aminolevulinic acid dehydratase, a biomarker of lead exposure [54]. Many traffic police officers showed neurobehavioral symptoms, which were consistent with high blood lead levels [55].…”

Section: Lead Studiesmentioning

confidence: 68%

Global review of studies on traffic police with special focus on environmental health effects

Patil¹,

Chetlapally²,

Bagavandas³

2014

International Journal of Occupational Medicine and Environmental Health

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Since occupation is a major determinant of health, traffic police personnel face multiple occupational hazards. They are continuously exposed to vehicular emissions and work in a noisy and polluted environment. The objective of the present review is to explore the impact of occupational health hazards on the health of traffic police personnel. Published research papers on traffic police reporting occupational health issues were accessed and reviewed. Attempts were made to access papers that reported negative associations in order to present a balanced review. The majority of the studies have reported a decrease in the lung function and increased respiratory morbidity. The research on the cytogenetic abnormalities or genotoxic effect of vehicular emissions arising due to long-term exposure to benzene and other polyaromatic hydrocarbons has provided conflicting results, since more or less equal numbers of studies have given evidence for and against the causal association. There is a vast accumulation of epidemiological evidence on the casual association between vehicular pollution and its carcinogenic effect. Multiple studies have concluded that traffic police are highly stressed. A number of occupational factors have been attributed to stress among traffic police. Occupational health studies help us to understand the effects of vehicular pollution and its adverse influence on workers. They also provide opportunity for defined exposures measurements and precise risk assessment. The findings from these studies are easily generalizable and can help us understand the impact of air pollution on the general population.

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“…In the current study, the mean blood lead level in control group was 28.460 ± 0.825. This high level could be attributed to many causes such as air pollution which is a serious problem in the major cities in Egypt (Ahmed et al, 1987). Eating fish from River Nile showing increased lead level from contamination by drainage of industrial discharges in it, as reported by El-Kattan et al, (2008).…”

Section: Discussionmentioning

confidence: 78%

“…Blood lead level has been accepted as the most reliable biomarker for lead toxicity (Al-Rudainy, 2010). Ahmed et al, (1987) reported that the acceptable blood lead level in Egypt is 30µg/dl. While the acceptable blood lead level in Tahran and in America are 9.33µg/d and 10 µg/dl respectively (Herman et al, 2007 andSadeghniiat-Haghighi et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Detection of Subclinical Neuropathies in Some Egyptian Workers Exposed To Lead (Cross-Sectional Study)

Hodeib

Heshmat

Soliman

et al. 2016

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Chronic lead toxicity is more common and serious for multiple organs. The objective of the present study was designed to detect subclinical neuropathies in Egyptian workers exposed to lead. A cross sectional study was carried out on sixty male Egyptian individuals; fifty workers were chronically occupationally exposed to lead and ten apparently healthy male volunteers not exposed to lead in their occupation served as a control group. All cases were subjected to clinical examination for lead toxicity. Neurological and nerve conduction study were done for both motor and sensory nerves. Estimation of blood and urine lead levels for all participants was done. A laboratory assessment was carried out for evaluation of hemoglobin level, reticulocytic count and basophilic stippling. The result of this study demonstrated elevation of both blood and urine lead levels of all workers. Increased in distal motor latency with slow conduction velocity and decreased amplitude of nerve conduction were observed in the studied nerves of all workers exposed to lead. Also, slow conduction velocity and decreased amplitude were the earliest and most sensitive finding of sensory conduction study of all workers exposed to lead. There were a significant correlation between blood and urine lead level, duration of exposure to lead and different parameters of nerve conduction. The present study concluded that nerve conduction either sensory or motor can give a clear image about chronic lead poisoning even with absence of any clinical findings (sub-clinical neuropathy). This study recommend periodic examination of workers exposed to lead for early detection and after recognition of these affected workers we must advise them improve their hygiene, use personal protective equipments or try to change their work and to notify industrial safety about them.

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Assessment of Lead Toxicity in Traffic Controllers of Alexandria, Egypt, Road Intersections

Cited by 24 publications

References 4 publications

Familial aggregation of colorectal cancer in Egypt

Familial aggregation of colorectal cancer in Egypt

Global review of studies on traffic police with special focus on environmental health effects

Detection of Subclinical Neuropathies in Some Egyptian Workers Exposed To Lead (Cross-Sectional Study)

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