Assessment of Left Atrial Function in Hypertrophic Cardiomyopathy and Athlete's Heart: A Left Atrial Myocardial Deformation Study

Gabrielli, Luigi; Enríquez, Andrés; Córdova, Samuel; Yáñez, Fernando; Godoy, Iván; Corbalán, Ramón

doi:10.1111/j.1540-8175.2012.01719.x

Cited by 59 publications

(54 citation statements)

References 34 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent study found that while a majority of endurance athletes had LA strains similar to controls, a subgroup was characterized by impaired strain, and suggested that this subgroup may operate at higher LA wall stress (Gabrielli et al 2014). Conversely, our data and others have demonstrated enhanced or preserved atrial strain following both short-and long-term endurance training (Gabrielli et al 2012), while LA strain is depressed in patients with hypertrophic cardiomyopathy (Gabrielli et al 2012). Thus it is possible that early in training, LA strain increases acutely with loading, before structural remodeling occurs and strain normalizes with prolonged endurance training.…”

Section: Myocardial Deformation Mechanicsmentioning

confidence: 59%

Left atrial functional changes following short-term exercise training

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Myocardial Deformation Mechanicsmentioning

confidence: 59%

Left atrial functional changes following short-term exercise training

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In another study by Sun et al demonstrated that all components of LA-SR in the hypertensive group were significantly lower than in athletes and normal controls (40) . Previous study showed that LA-S and SR were significantly decreased in patients with HCM than in highly trained athletes and healthy controls and provided valuable additional information to that obtained by conventional echocardiography in the differential diagnosis between pathological and physiological LVH (28) . Moreover, recent studies have found pathological LVH in long-term AAS users.…”

Section: Discussionmentioning

confidence: 95%

“…The physiological hypertrophy that occurs in athletes is associated with increased ventricular mass, normal organization of cardiac structure, and no increase in collagen content. On the other side, the hypertrophy observed in AAS using bodybuilders is characterized by myofibrillar disarray and collagen accumulation, eventually leading to systolic and diastolic dysfunction (27,28) .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Left Atrial Function in Long-Term Anabolic/Androgenic Steroid Users versus Nonuser Bodybuilders by Using Two- Dimensional Speckle-Tracking Echocardiography

Alızade¹

2017

Kosuyolu Heart Journal

View full text Add to dashboard Cite

Introduction:Long-term illicit use of supraphysiological doses of anabolic/androgenic steroids (AAS) may cause pathological left ventricular hypertrophy (LVH), diastolic dysfunction, left atrial (LA) hypertrophy, increased myocardial stiffness, and myocardial fibrosis. Therefore, distinguishing AAS-using athlete's hearts from the nonpathological "athlete's heart" is critically important. The aim of this study was to evaluate LA myocardial function using 2D-STE method in both AAS-using and drug-free bodybuilders, and assess its potential role in the differential diagnosis between these two entities. Patients and Methods:We selected a population of 33 male, competitive bodybuilders, including 15 actively using AAS for > 2 years (users) and 18 who had never used AAS (nonusers).Results: AAS users had a significantly lower global LA strain reservoir (GLAS-R), global LA strain during early diastole (GLAS-E; 38.2 ± 8.4 vs. 48.6 ± 11.9, p< 0.01; 24.4 ± 8.6 vs. 37.1 ± 12.8, p< 0.01; respectively), global LA strain rate reservoir (GLASR-R), global LA strain rate during early diastole (GLASR-E; 1.8 ± 0.3 vs. 2.2 ± 0.4, p< 0.01; -1.4 ± 0.2 vs. -1.8 ± 0.3, p< 0.01; respectively) than nonusers. The univariate correlation analysis demonstrated that GLAS-R, GLAS-E, GLASR-R, and GLASR-E had a good inverse correlation with E/Em (r: -0.34, p= 0.04; r: -0.35, p= 0.04; r: -0.35, p= 0.04, and r: -0.35, p= 0.04, respectively). Conclusion:The present study confirms that LA strain and strain rate are impaired in AAS users compared to nonusers and provide valuable additional information to that obtained by conventional echocardiography in the differential diagnosis between pathological and physiological LVH. Bulgular: AAS kullanan atletlerin global SA strain reservoir (GLAS-R), global SA erken diyastol strain (GLAS-E) (38.2 ± 8.4 vs. 48.6 ± 11.9, p< 0.01; 24.4 ± 8.6 vs. 37.1 ± 12.8, p< 0.01; sırasıyla), global SA strain rate reservoir (GLASR-R), global SA erken diyastol strain rate (GLAS-E) (1.8 ± 0.3 vs. 2.2 ± 0.4, p< 0.01; -1.4 ± 0.2 vs. -1.8 ± 0.3, p< 0.01; sırasıyla) değerlerinin kullanmayan sporculara göre önemli ölçüde azaldığı görüldü. Univaryant korelasyon analizi GLAS-R, GLAS-E, GLASR-R ve GLASR-E değerlerinin E/Em (r: -0.34, p = 0.04; r: -0.35, p= 0.04; r: -0.35, p= 0.04 and r: -0.35, p= 0.04, sırasıyla) ile ters korelasyon olduğunu gösterdi.Sonuç: Bu çalışma SA strain ve strain rate değerlerinin AAS kullanan sporcularda kullanmayan sporculara göre azaldığı, ayrıca patolojik ve fizyolojik SVH ayırıcı tanısında konvansiyonel ekokardiyografi ile elde edilen bulgulara ek değerli bilgiler sağladığı doğrulanmıştır.

show abstract

“…Nach dieser Zeit beginnt jedoch die Rückbildung der antrainierten Hypertrophie und führt bereits nach 8 Wochen zu signifikanten Dimensionsverminderungen und zur Reduzierung der Werte kardialer Funktionsmessungen, wie der Verkürzungsfraktion (FS) und des Herzzeitvolumens (Kriz et al 2000). Auch Gewebedopplermessungen zeigten beim Menschen trainingsbedingte Veränderungen (Caso et al 2000, Vinereanu et al 2001, D'Andrea et al 2001und 2010, Poulsen et al 2007, Gabrielli et al 2012 …”

Section: Introductionunclassified

Influence of 3 month of training on heart size and myocardial function in trotters

Gehlen¹,

Schlaga²

2017

PHK

View full text Add to dashboard Cite

Zusammenfassung: Um den eventuellen Effekt einer kardialen Dekonditionierung zu erfassen, wurde in dieser Studie eine Gruppe zweijähriger gesunder Trabrennpferde im trainierten Zustand (Rennkondition) und nach einer Trainingspause klinisch und echokardiographisch untersucht. Als echokardiographische Untersuchungsmethoden wurden neben der B-, M-Mode und Farbdopplertechnik auch der Gewebedoppler (Farb-und Spektralgewebedoppler) Influence of 3 month of training on heart size and myocardial function in trottersTo evaluate a possible effect of cardiac deconditioning, a group of 2-year old healthy trotters was examined clinically and by echocardiography in racing condition and after a period of rest. Echocardiographic examinations included 2DE, M-mode, Doppler, TVI assessment (spectral and colour TVI) as well as speckle tracking analysis. Overall, 12 horses were examined twice (trained vs. rested) at a three month interval. Heart sized and myocardial thickness were evaluated by using 2DE and M-mode, all valves by colour Doppler. Myocardial velocities were measured by spectral and colour TVI in the left free ventricular wall, the interventricular septum and the right ventricular wall in radial orientation from right parasternal short-axis echocardiograms. Myocardial deformation parameters strain and strain rate were evaluated by speckle tracking analysis of the left ventricular wall and the interventricular septum from 2DE images. After three month of rest, a significant increase of the left ventricular free wall by 14.54 % (P = 0.006) was found in 2DE images compared to horses in race training. The left ventricular inner diameter had decreased by 4.99 % (P = 0.048). In addition, the isovolumetric relaxation time of the left ventricular free wall showed a significant reduction of 9.52 % (P = 0.040) in spectral Doppler imaging. Ejection time from the left ventricle was increased significantly by 4.69 % (P = 0.019) in colour TVI. Speckle tracking analysis showed a significant increase of early diastolic strain rate in the interventricular septum (P = 0.020). There were no significant differences in all other parameters studied. As all horses had access to pasture during the resting period, voluntary exercise might have been sufficient to compensate for race training.

show abstract

Assessment of Left Atrial Function in Hypertrophic Cardiomyopathy and Athlete's Heart: A Left Atrial Myocardial Deformation Study

Abstract: LA myocardial deformation is significantly impaired in patients with HCM compared to athletes and healthy controls. LA strain and strain rate assessed by 2D speckle tracking should be incorporated in the evaluation of trained athletes with LVH and LA dilatation.

Cited by 59 publications

References 34 publications

Left atrial functional changes following short-term exercise training

Left atrial functional changes following short-term exercise training

Comparison of Left Atrial Function in Long-Term Anabolic/Androgenic Steroid Users versus Nonuser Bodybuilders by Using Two- Dimensional Speckle-Tracking Echocardiography

Influence of 3 month of training on heart size and myocardial function in trotters

Contact Info

Product

Resources

About