2017

DOI: 10.4172/2327-5146.1000296

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Assessment of Left Atrial Functions in Patients with Prediabetes

Öykü Gülmez¹,

Hülya Parıldar²,

Özlem Ciğerli³

et al.

Abstract: Background: LA volumes and functions are reported to be independent predictors of cardiovascular events in general and diabetic population. The aim of this is to evaluate the effects of prediabetes on LA volumes and functions and parameters that effect LA volumes and functions in patients with prediabetes.

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“…Left atrial phasic function assessment was done using the following formulas 10 :

\begin{matrix} Reservoir function : LA emptying fraction total = ((LA max ‐ LA min) / LA max) \times 100 %; \\ expansion index = ((LA max ‐ LA min) / LA min) \times 100 % \end{matrix}

\begin{matrix} Conduit function : Passive emptying volume = LA max ‐ Vpre ‐ A; \\ passive LA emptying fraction = ((LA max ‐ Vpre ‐ A) / LA max) \times 100 % \end{matrix}

\begin{matrix} Contractile function : LA active emptying fraction = ((LA pre ‐ A ‐ LA min) / LA pre ‐ A) \times 100; \\ LA active emptying volume = V pre ‐ A ‐ LA min \end{matrix}

…”

Section: Methodsmentioning

confidence: 99%

Left atrial structural and functional remodeling study in type 2 diabetic patients in sub‐Saharan Africa: Role of left atrial strain by 2D speckle tracking echocardiography

¹

,

Nganou–Gnindjio

²

,

³

et al. 2020

Echocardiography

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Objective To evaluate the role of peak atrial longitudinal strain (PALS) through speckle tracking 2D echocardiography for the assessment of structural and functional left atrial (LA) remodeling in a type 2 diabetes mellitus (T2DM) population. Methodology We conducted a cross‐sectional study during a 9‐month period. T2DM adults aged 18 and above were included. The variables assessed during the study include age and gender of participants, diabetes characteristics, cardiovascular risk factors, clinical anthropometric and hemodynamic parameters, standard echocardiographic parameters, volume‐derived LA functions, and 2D PALS. Results We included a total of 102 patients. The mean age was 58 ± 11.7 years, and the M/F sex ratio was 1:1.5. Coexistent arterial hypertension (HTN) was observed in more than half (59.8%) of the population sample. Mean 2D PALS was 29.2 ± 8.9% with 58.8% (95% CI: 50.0–68.6) of subjects having a reduced LA strain (ie,<32%). Reservoir and pump functions were the most altered LA volumetric phasic functions. Mean indexed LA maximal volume was 22.2 ± 6.8 mL/m2. There was a significant association between abnormal PALS and age, Body mass index (BMI), indexed LA volume, E/E’ ratio, LA active ejection fraction (pump function), and LA expansion index (reservoir function). Conclusion Left atrial remodeling is a recurrent condition in adult T2DM Cameroonians. The reservoir and pump LA functions were the most affected. Assessment of LA global strain allows early detection of LA remodeling with comparison to LA size standard analyses. Age, BMI, indexed LA volume, E/E’ ratio, and reservoir and pump LA functions were associated to 2D LA global strain impairment.

“…Left atrial phasic function assessment was done using the following formulas 10 :

\begin{matrix} Reservoir function : LA emptying fraction total = ((LA max ‐ LA min) / LA max) \times 100 %; \\ expansion index = ((LA max ‐ LA min) / LA min) \times 100 % \end{matrix}

\begin{matrix} Conduit function : Passive emptying volume = LA max ‐ Vpre ‐ A; \\ passive LA emptying fraction = ((LA max ‐ Vpre ‐ A) / LA max) \times 100 % \end{matrix}

\begin{matrix} Contractile function : LA active emptying fraction = ((LA pre ‐ A ‐ LA min) / LA pre ‐ A) \times 100; \\ LA active emptying volume = V pre ‐ A ‐ LA min \end{matrix}

…”

Section: Methodsmentioning

confidence: 99%

Left atrial structural and functional remodeling study in type 2 diabetic patients in sub‐Saharan Africa: Role of left atrial strain by 2D speckle tracking echocardiography

¹

,

Nganou–Gnindjio

²

,

³

et al. 2020

Echocardiography

View full text Add to dashboard Cite

Objective To evaluate the role of peak atrial longitudinal strain (PALS) through speckle tracking 2D echocardiography for the assessment of structural and functional left atrial (LA) remodeling in a type 2 diabetes mellitus (T2DM) population. Methodology We conducted a cross‐sectional study during a 9‐month period. T2DM adults aged 18 and above were included. The variables assessed during the study include age and gender of participants, diabetes characteristics, cardiovascular risk factors, clinical anthropometric and hemodynamic parameters, standard echocardiographic parameters, volume‐derived LA functions, and 2D PALS. Results We included a total of 102 patients. The mean age was 58 ± 11.7 years, and the M/F sex ratio was 1:1.5. Coexistent arterial hypertension (HTN) was observed in more than half (59.8%) of the population sample. Mean 2D PALS was 29.2 ± 8.9% with 58.8% (95% CI: 50.0–68.6) of subjects having a reduced LA strain (ie,<32%). Reservoir and pump functions were the most altered LA volumetric phasic functions. Mean indexed LA maximal volume was 22.2 ± 6.8 mL/m2. There was a significant association between abnormal PALS and age, Body mass index (BMI), indexed LA volume, E/E’ ratio, LA active ejection fraction (pump function), and LA expansion index (reservoir function). Conclusion Left atrial remodeling is a recurrent condition in adult T2DM Cameroonians. The reservoir and pump LA functions were the most affected. Assessment of LA global strain allows early detection of LA remodeling with comparison to LA size standard analyses. Age, BMI, indexed LA volume, E/E’ ratio, and reservoir and pump LA functions were associated to 2D LA global strain impairment.

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