Assessment of Left Ventricular Ejection Fraction by Thallium-201 Myocardial SPECT-CT in Patients with Angina Pectoris: Comparison with 2D Echocardiography

Kim, Ji Young; Park, Hwan Cheol; Kim, Soo Jeong; Chang, Hyung Seok; Choi, Hyung Jin; Kim, Young Hwan

doi:10.1007/s13139-019-00575-0

Cited by 2 publications

(2 citation statements)

References 32 publications

(31 reference statements)

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“…The LVEF was different in only three patients and the largest difference, observed in two patients, was 7%. Kim et al compared LVEF using 201 TlCl-MPI with CTAC and using 2D echocardiography [15]. They observed a moderate correlation between the two and similar results with non-attenuation corrected MPI.…”

Section: Discussionmentioning

confidence: 96%

Evaluating the effectiveness of a single CT method for attenuation correction in stress-rest myocardial perfusion imaging with thallium-201 chloride SPECT

Fukami

Tamura

Nakamura

et al. 2019

Radiol Phys Technol

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This study aimed to evaluate the effectiveness of a single computed tomography (CT) based attenuation correction method using thallium-201 chloride ( 201 TlCl) in stress-rest myocardial perfusion imaging (MPI). The data of 106 patients who underwent MPI with single photon emission computed tomography (SPECT) using 201 TlCl were retrospectively reviewed. MPI SPECT images were reconstructed using stress SPECT and stress CT (SI O ), rest SPECT and rest CT (RI O ), and rest SPECT and stress CT (RI A ). The accuracy of alignment between the SPECT and CT images was evaluated with normalized cross-correlation (NCC) and visual examination. The summed rest score (SRS) was used to evaluate hypoperfusion at rest; washout rate (WO) was used to assess ischemia; and left ventricular ejection fraction (LVEF) was used to evaluate the left ventricle (LV) function. There was no significant difference in NCC and visual evaluation in all three dimensions. The SRS of both RI O and RI A (7.5 ± 7.7 and 7.7 ± 7.6, respectively) did not differ significantly. However, SRSs of RI O and RI A showed a strong correlation (r = 0.98). The WO was 39.0 ± 0.98% for both RI O and RI A , with a strong correlation between the two values (r = 1.00). LVEF was 61.1 ± 17.4% for RI O and 61.3 ± 17.4% for RI A , and a strong correlation was observed between the two values (r = 1.00). In conclusion, the single CT-based attenuation correction method with 201 TlCl SPECT has an accuracy equivalent to that of the conventional two CT-based attenuation correction method.

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Section: Discussionmentioning

confidence: 96%

Evaluating the effectiveness of a single CT method for attenuation correction in stress-rest myocardial perfusion imaging with thallium-201 chloride SPECT

Fukami

Tamura

Nakamura

et al. 2019

Radiol Phys Technol

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“…201 Tl is used for assessing heart function such as assessing cardiac systolic function and predicting prognosis in patients with cardiovascular disease. [ 22 ] 123 I is the most suitable isotope of iodine for the diagnostic study of thyroid diseases. Recently it was used to identify myocardial sympathetic denervation patterns in patients with Parkinson's disease.…”

Section: Introductionmentioning

confidence: 99%

Assessment of single- and double-strand breaks in DNA induced by auger electrons of radioisotopes used in diagnostic and therapeutic applications

Moradi

Bidabadi

2020

J Med Phys

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Introduction: Most of the radionuclides that are used for diagnostic purposes emit Auger electrons and can thus cause damage to the DNA molecule on a nanometer scale. Therefore, the nanodosimetric calculation of these radioisotopes is necessary to achieve better understanding on their effects. Aim: The aim of this study was to calculate the mean number of DNA strand breaks (single-strand breaks and double-strand breaks) caused by direct and indirect effects for six widely used Auger electron-emitting diagnostic radioisotopes, including 123 I, 125 I, 99m Tc, 67 Ga, 201 Tl, 111 In and two therapeutic radioisotopes of 131 I(beta + Auger + CK emitter) and 211 At(alpha + Auger + CK emitter). Materials and Methods: Geant4-DNA simulation tool was used to evaluate the effects of Auger electrons, beta and alpha particles of these radioisotopes on DNA molecules. Two different DNA molecule geometric models were simulated and the results of these two models were compared with each other as well as with the results of previous studies. Results and Conclusion: The results showed that the geometric shape of the sugar-phosphate groups may have a significant effect on the number of single-strand breaks (SSBs) and double-strand breaks (DSBs) of the DNA molecule. Among the most widely used diagnostic radioisotopes, 201 Tl and 125 I, had the greatest impact on the number of SSBs and DSBs, respectively, while therapeutic radioisotope of 131 I almost had no effect, therapeutic radioisotope of 211 At had the moderate effect on the number of breaks in the DNA chain.

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Assessment of Left Ventricular Ejection Fraction by Thallium-201 Myocardial SPECT-CT in Patients with Angina Pectoris: Comparison with 2D Echocardiography

Cited by 2 publications

References 32 publications

Evaluating the effectiveness of a single CT method for attenuation correction in stress-rest myocardial perfusion imaging with thallium-201 chloride SPECT

Evaluating the effectiveness of a single CT method for attenuation correction in stress-rest myocardial perfusion imaging with thallium-201 chloride SPECT

Assessment of single- and double-strand breaks in DNA induced by auger electrons of radioisotopes used in diagnostic and therapeutic applications

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