Assessment of Left Ventricular Function by Layer-Specific Strain and Its Relationship to Structural Remodelling in Patients With Hypertension

Kim, Su A.; Park, Seong‐Mi; Kim, Seung Up; Shim, Wan Joo

doi:10.1016/j.cjca.2015.04.025

Cited by 60 publications

(40 citation statements)

References 20 publications

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“…Previous studies have reported that endomyocardial strain is more susceptible to negative factors, such as ischemia, stress, toxicity, and metabolism. 15,19,[32][33][34] This finding is consistent with the finding in our study that LSendo and CSendo were decreased. This condition may be caused by coronary atherosclerosis and increased intima-media thickness, which may both result in myocardial ischemia.…”

Section: Discussionsupporting

confidence: 93%

Myocardial layer‐specific analysis in patients with heterozygous familial hypercholesterolemia using speckle tracking echocardiography

Leng

et al. 2017

Echocardiography

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Section: Discussionsupporting

confidence: 93%

Myocardial layer‐specific analysis in patients with heterozygous familial hypercholesterolemia using speckle tracking echocardiography

Leng

et al. 2017

Echocardiography

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“…Mid‐myocardial GLS was shown to be an equally good predictor of CAD in patients with reversible ischemia as layer‐specific GLS in terms of AUC's (Figure ) and was significantly impaired in patients with a true‐positive SPECT (Table ). In the present study, layer‐specific GLS showed a decreasing gradient from the endocardium to the epicardium in both controls and patients with a positive SPECT, in agreement with previous studies . Endocardial GLS failed to stay independently associated with the presence of CAD after multivariable adjustment in contrast to epicardial and mid‐myocardial GLS (Table ), although the difference between GLS parameters lacked significance in terms of AUC's (Figure ).…”

Section: Discussionsupporting

confidence: 91%

“…[33][34][35][36] Endocardial GLS failed to stay independently associated with the presence of CAD after multivariable adjustment in contrast to epicardial and mid-myocardial GLS ( Table 2), although the difference between GLS parameters lacked significance in terms of AUC's ( Figure 3). The notable finding is in contrast to previous studies [34][35][36] and requires further investigation; however, our population of patients with suspected SAP (not suspected acute coronary syndrome or hypertension) differs significantly from the previous studies, [34][35][36] which might explain the different results, or it could simply be due to the better reproducibility ( Figure 6) and superior tracking of the epicardial layer as compared to the endocardial layer. A still-unpublished independent study of layer-specific GLS including 285 patients prospectively enrolled with suspected SAP, preserved LVEF, and no previous cardiac history performed by our group showed that epicardial and mid-myocardial GLS appeared superior to endocardial GLS for diagnosing CAD, indicating that the notable finding in the present study was not caused by limitations related to this study (abstr.…”

Section: Discussionmentioning

confidence: 98%

Layer‐specific global longitudinal strain reveals impaired cardiac function in patients with reversible ischemia

et al. 2018

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“…On the other hand, midmyocardial layer strain was lower in hypertensive patients than in controls and WCH patients. Kim and colleagues 21 recently demonstrated that LV longitudinal strain in all three layers (subendocardial, midmyocardial, and subepicardial) were lower in hypertensive patients, whereas Ishizu and colleagues 22 showed that LV wall strain changings were accompanied by myocyte hypertrophy and fibrosis from subendocardium to epicardium in an animal model. The latter study revealed that longitudinal strain is associated with subendocardial layer fibrosis.…”

Section: Discussionmentioning

confidence: 99%

The Impact of White‐Coat Hypertension on Cardiac Mechanics

Tadić

Cuspidi

Ivanović

et al. 2016

J of Clinical Hypertension

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The authors aimed to investigate right ventricular (RV) and left ventricular (LV) remodeling in patients with white-coat hypertension (WCH) and sustained arterial hypertension. This cross-sectional study included 153 untreated patients who underwent 24-hour ambulatory blood pressure (BP) monitoring and complete two-dimensional echocardiographic (2DE) examination. Results showed that LV and RV longitudinal mechanics gradually deteriorated from controls to patients with sustained hypertension. Endocardial RV longitudinal strain was lower in WCH and hypertensive patients than in controls. Midmyocardial RV longitudinal strain was decreased in hypertensive patients compared with the other two groups, whereas subepicardial RV longitudinal strain was similar between the observed groups. Twenty-four-hour systolic BP was associated with 2DE global longitudinal LV and subendocardial RV strain. This study demonstrates that myocardial deformation of both ventricles is significantly impaired in patients with WCH and sustained arterial hypertension, and 24-hour systolic BP is associated with LV and RV deformation independent of cardiac structure. J Clin Hypertens (Greenwich). 2016;18:617-622. ª 2016 Wiley Periodicals, Inc.The definition of white-coat hypertension (WCH) has been a subject of debate in the past two decades.1 A recent study showed that persistent WCH is associated with elevated long-term cardiovascular mortality.2 Furthermore, investigators showed that WCH was associated with significantly higher cardiovascular mortality risk than prehypertension, even after adjustment for demographic and clinical parameters (age, sex, body mass index [BMI], smoking, fasting plasma glucose, and total cholesterol/high-density lipoprotein cholesterol ratio). 3The influence of WCH on cardiac remodeling, and especially on left ventricular (LV) functional and structural alterations, has been previously demonstrated.4-6 Our recent meta-analysis that included 1705 WCH patients confirmed the unfavorable effect of WCH on LV structure and function.7 However, not all investigators agree about the impact of WCH on LV remodeling. 8Thus far, right ventricular (RV) structure and function has not been evaluated in WCH patients. Considering the importance of RV dysfunction in the prediction of mortality in patients with different conditions (heart failure with/without preserved LV function, pulmonary hypertension, cardiomyopathies, heart valve disease, congenital heart disease), [9][10][11][12] it is necessary to understand why RV remodeling represents a potentially important part in a complex puzzle of target organ damage in WCH patients. Moreover, our previous investigations have demonstrated the negative influence of arterial hypertension and high-normal blood pressure (BP) on RV structure, function, and mechanics. 13,14Based on our previous findings regarding the significant inverse relationship between BP level and RV remodeling, we hypothesized that WCH could impact RV function and mechanics.The aim of the present study was to investigate ...

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Assessment of Left Ventricular Function by Layer-Specific Strain and Its Relationship to Structural Remodelling in Patients With Hypertension

Cited by 60 publications

References 20 publications

Myocardial layer‐specific analysis in patients with heterozygous familial hypercholesterolemia using speckle tracking echocardiography

Myocardial layer‐specific analysis in patients with heterozygous familial hypercholesterolemia using speckle tracking echocardiography

Layer‐specific global longitudinal strain reveals impaired cardiac function in patients with reversible ischemia

The Impact of White‐Coat Hypertension on Cardiac Mechanics

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