2017
DOI: 10.1111/echo.13463
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Assessment of left ventricular functions and myocardial iron load with tissue Doppler and speckle tracking echocardiography and T2* MRI in patients with β‐thalassemia major

Abstract: Although T2* MRI is the most sensitive test detecting myocardial iron load, TDI and STE can be used for screening myocardial dysfunction. The abnormal strain values, especially circumferential, may be detected as the first finding of abnormal iron load and related to T2* values.

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Cited by 28 publications
(41 citation statements)
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“…1 The second main finding of our study is the weak or absent correlations between the myocardial deformation parameters and iron indices in the serum. This observation is in agreement with the results regarding other iron-overload syndromes 34,48,49 and allows us to suggest that there is the absence of a "direct" relationship between the levels of iron turnover parameters and myocardial function and that myocardial iron overload is not the only mechanism involved in the development of HH cardiomyopathy.…”
Section: Discussionsupporting
confidence: 91%
“…1 The second main finding of our study is the weak or absent correlations between the myocardial deformation parameters and iron indices in the serum. This observation is in agreement with the results regarding other iron-overload syndromes 34,48,49 and allows us to suggest that there is the absence of a "direct" relationship between the levels of iron turnover parameters and myocardial function and that myocardial iron overload is not the only mechanism involved in the development of HH cardiomyopathy.…”
Section: Discussionsupporting
confidence: 91%
“…The most common in-use procedures include cardiac magnetic resonance imaging (CMRI), [18][19][20] and echocardiography. 19,21 In fact, CMRI procedure could be a reliable method based on the chelation therapeutic strategy.…”
Section: Methods Of Estimating Cardiac Iron Overloadmentioning
confidence: 99%
“…The most common in-use procedures include cardiac magnetic resonance imaging (CMRI), [18][19][20] and echocardiography. 19,21 In fact, CMRI procedure could be a reliable method based on the chelation therapeutic strategy. 22 However, CMRI as the gold standard method for cardiac iron assessment is not available in many care centers especially in third world nations such as Iran.…”
Section: Methods Of Estimating Cardiac Iron Overloadmentioning
confidence: 99%
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“…However, in this population, studies are rare and results are conflicting. [11][12][13][14][15][16] More recently, the GLS was found to be altered in a population of patients with β-thalassemia, [17,18] a hemoglobinopathy that can, in some respects, be compared with SCD.…”
Section: Journal Of Translational Internal Medicine / Jan-mar 2020 / mentioning
confidence: 99%