Assessment of Left Ventricular Systolic Asynchrony in Patients with Clinical Hypothyroidism

Kaplan, Şahin; Kırış, Abdülkadir; Erem, Cihangir; Kaplan, Tuba; Kırış, Gülhanım; Gedikli, Ömer; Koçak, Mustafa; Baykan, Merih; Çelık, Şükrü

doi:10.1111/j.1540-8175.2009.00982.x

Cited by 18 publications

(31 citation statements)

References 46 publications

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“…Recently, we have reported the presence of LV asynchrony in overt hypothyroidism [37]. However, both hyperthyroidism and hypothyroidism leads to many changes in blood pressure, cardiac output and contractility, myocardial oxygen consumption [2,38].…”

Section: Discussionmentioning

confidence: 99%

Intra-left ventricular systolic asynchrony in patients with overt hyperthyroidism

Kırış¹,

Erem

Kırış

et al. 2010

Endocr

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Hyperthyroidism causes a variety of adverse effects on the cardiovascular system. Left ventricular (LV) asynchrony is defined as loss of the simultaneous peak contraction of corresponding cardiac segments. The aim of this study was to assess systolic asynchrony in patients with overt hyperthyroidism. Asynchrony was evaluated in 27 patients with overt hyperthyroidism and 21 controls. All the patients and controls were subjected to a tissue synchronization imaging (TSI). The time to regional peak systolic tissue velocity (Ts) in LV by the six-basal-six-mid-segmental model was measured on ejection phase TSI images and four TSI parameters of systolic asynchrony were computed. All TSI parameters of LV asynchrony increased in hyperthyroid patients compared to controls: the standard deviation (SD) of the 12 LV segments Ts (35.7±14.4 vs 20.1±10.1, P<0.0001); the maximal difference in Ts between any 2 of the 12 LV segments (111.9±40.7 vs 65.9±30.7, P<0.0001); the SD of the 6 basal LV segments (31.2±18.2 vs 16.8±9.7, P=0.01); and the maximal difference in Ts between any 2 of the 6 basal LV segments (76.6±42.0 vs 44.4±25.7, P=0.005). Patients with overt hyperthyroidism present evidence of LV asynchrony by TSI.

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Section: Discussionmentioning

confidence: 99%

Intra-left ventricular systolic asynchrony in patients with overt hyperthyroidism

Kırış¹,

Erem

Kırış

et al. 2010

Endocr

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“…Overt hypothyroidism impairs early and late regional and global diastolic peak longitudinal LV strain rates (35,36). In addition, tissue Doppler-derived e' and the e'/a' ratios are reduced, and the myocardial performance index may be prolonged (37).…”

Section: Discussionmentioning

confidence: 99%

Effects of Subclinical and Overt Primary Hypothyroidism on the Cardiac Function and their Reversibility under Treatment Using Tissue Doppler Echocardiography

Tanase¹

2014

Acta Endo (Buc)

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Background. The modifications of blood pressure and lipid metabolism, the decrease of heart contractility and the increase of systemic vascular resistance that accompany hypothyroidism are caused by the decreased action of thyroid hormones.Objective. The purpose of this study is to evaluate, using echocardiography, the changes of the heart functional parameters in patients with untreated thyroid dysfunctions.Pacients and Methods. Study group included 348 patients for an evaluation of cardiovascular and thyroid status. The control of the thyroid condition was conducted using measurements of the FT3, FT4 and TSH levels, echocardiographic measurements defining the parameters of the function of the left ventricle.Results. The study group was divided into subclinical hypothyroidism (SH, 75 cases), overt hypothyroidism (OH, 123 patients) and normal thyroid function (C, 150 patients). TSH values decreased (from 5.8±15 mUI/L to 2.28±0.63 mUI/L in SH and from 20.23±17.33 mUI/L to 4.24±0.24 mUI/L in OH) after one year of treatment while fT4 and fT3 increased. The parameters obtained revealed significant decreases of the E/A ratio in both groups with hypothyroidism. The isovolumetric relaxation time was significantly higher in SH and OH as compared to the control group (C: 112.50±35.45 msec, SH: 118.75±16.52 msec p<0.05, OH: 130±41.83 msec p<0.001). In addition, the tissue Doppler revealed significant decreases of the E'/A' ratio, measured septally and laterally in the group with overt and subclinical hypothyroidism.Conclusion. In hypothyroidism the systolic and predominantly diastolic function of the left ventricle are impaired. These dysfunctions are reversible under L-T4 substitutive treatment.

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“…Dyssynchrony was first emphasized in the early studies in systolic HF patients with low EF and wide QRS complex, however, 1/3 of HF patients with a narrow QRS complex were found to exhibit substantial mechanical dyssynchrony as well . Recently, systolic dyssynchrony was not only detected in the patients with symptoms of HF and preserved EF but also in hypertension, diabetes mellitus, acute myocardial infarction, and hypo‐ and hyperthyroidism . Recent studies revealed that systolic dyssynchrony is an important co‐determinant of progression and exacerbation of HF …”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Dyssynchrony Is an Early Manifestation of Heart Involvement in Sickle Cell Anemia

et al. 2013

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Assessment of Left Ventricular Systolic Asynchrony in Patients with Clinical Hypothyroidism

Abstract: Patients with overt hypothyroidism show evidence of LV asynchrony by TSI.

Cited by 18 publications

References 46 publications

Intra-left ventricular systolic asynchrony in patients with overt hyperthyroidism

Intra-left ventricular systolic asynchrony in patients with overt hyperthyroidism

Effects of Subclinical and Overt Primary Hypothyroidism on the Cardiac Function and their Reversibility under Treatment Using Tissue Doppler Echocardiography

Left Ventricular Dyssynchrony Is an Early Manifestation of Heart Involvement in Sickle Cell Anemia

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