Objective: To compare the modalities 3D-echocardiography (RT3DE) and cardiac magnetic resonance as well as semiautomatic non-model-based and model-based quantification software (SWP-MRI and SWT-MRI) regarding accuracy and agreement of left ventricular functional indices.Methods: 9 asymmetrically shaped gel phantoms (range: 20-350ml), 24 healthy children (age=11.4±3.3y) and 11 patients with abnormally shaped left ventricles (22.0±17.0y) were prospectively investigated. 3D-echocardiography was performed using a Vivid 7 ultrasound machine (V3 matrix transducer); postprocessing was done with a model-based analysis strategy (SWT-echo). CMR datasets were obtained using a multi-slice multi-phase steady-state-free-precision acquisition (TR/TE/flip=2.8msecs/1.4msecs/60°) with a 1.5T MR system. Volume quantification was done using the same model-based software for CMR as well as non model-based software based on the summation of discs method. Agreement of EDV, ESV and EF between SWT-echo, SWP-mri vs. SWT-mri was determined by Bland Altman analysis.Results: Phantom study revealed high accuracy (<1%) for SWT-echo and SWP-mri as well as a moderate underestimation for SWT-MRI (13%). Agreement between SWP-mri and SWT-echo was superior in volunteers [mean; limits-ofagreement: EDV(5.3%; -20.1 to 30.8%), ESV(-1.3%; -41.6 to 38.9%), EF(4.0%; -12.0 to 19.9%)] with only slight underestimation by RT3DE in patients [EDV(11.5%; -18.5 to 41.4%), ESV(13.0%; -5.4 to 31.5%), EF(-6.9%; -49.9 to 36.1%)]. Comparing SWT-echo with SWT-mri revealed volume underestimation of EDV (9.8; -20.5 to 40.0%) and overestimation of ESV (-9.6; -60.1 to 41.0%) in volunteers by SWT-mri resulting in underestimation of EF (12.6;-9.6 to 34.9). In patients minor differences between SWT-echo and SWT-mri were observed [EDV (0.6%; -28.2 to 29.4%), ESV (-2.4%; -38.2 to 33.4%), EF(9.3%; -35.7 to 54.3%)]. Compared to our reference SWP-mri both model-based techniques moderately underestimated EDV (SWT-MRI 12.1%; -2.1 to 26.4%, SWT-echo 11.5%; -18.5 to 41.4%) and ESV
Key wordsMagnetic resonance imaging, Three-dimensional echocardiography, Left ventricular function, Pediatrics, Quantitative evaluation
BackgroundAccurate assessment of left ventricular (LV) indices is indispensable for children with cardiac disease having diagnostic and prognostic implications [1] . This is especially important for the decision making in small borderline ventricles as well as in dilated ventricles because of volume overload regarding the kind and timing of further treatment. Most non-invasive imaging modalities such as 2D-Echocardiography are using geometric assumptions and therefor lack accuracy in the assessment of the patients with abnormally shaped ventricles [2] . Currently, cardiovascular magnetic resonance imaging (CMR) is regarded as the first line imaging technique for the evaluation of ventricular volumes, mass and function both in normally shaped as well as in abnormally shaped ventricles as stated by a consensus panel report [3] because of its high accuracy, reproducibi...