Assessment of Lens Culinaris Agglutinin-Reactive Fraction of Alpha Fetoprotein as an Early Diagnostic Marker for Hepatocellular Carcinoma among Sudanese Patients with Chronic Liver Disease

Shata, Yousif M.; Mudawi, Salma B. M.; Fedail, S S; Al, Badr Aldeen Hassan; Ismaeil, Ammar Mohammed; Ahmed, Samia Mahdi

doi:10.13189/cor.2014.020101

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…From a gender perspective, AFP levels above 400 ng/ml belonged to male patients, and normal AFP levels below 20 ng/ml belonged to the majority of female patients. This was contradictory to the research from Shata et al, (2014) who found that there was no difference in AFP levels between men and women (Shata, et al, 2014).…”

Section: Discussioncontrasting

confidence: 66%

Serum Afp (Alpha Feto Protein) Levels Profile of Hepatocellular Carcinoma Patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Putri

Maimunah

Retnowati

2022

MBIOM

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Higlight:1. The USG results of AFP level can be used for early detection and therapy of hepatocellular carcinoma that can prevent metastasis, progressivity, and recurrence. 2. The most common patients with high AFP levels are those with hepatitis B depending on etiology, younger age, male, gender, high SGOT level and BCLC B patients.Abstract:Background: Hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancer which is the second most common cause of cancer-related death worldwide. The incidence of HCC was 626.000 cases every year worldwide. Early detection and therapy can prevent metastasis, progressivity, and recurrence. AFP level ≥ 400 ng/ml and USG results can be used as a diagnosis parameter of hepatocellular carcinoma. Objective: To analyze the AFP level’s profile in hepatocellular carcinoma. Materials and Methods: Descriptive methods used in this study with data collected from medical records on patients that fulfilled the inclusion criteria in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia during the periods of 1st January 2013- December 31st 2015. This study used various variables such as age, gender, etiology and size of the tumor, number of a nodule, hepatic function with child classification, staging BCLC, and AFP level. Results: This study found that the 98 patients with hepatocellular carcinoma with high AFP level or >400 ng/ml were dominated by younger patients with average age of 49.91 years, the most common etiology was hepatitis B (56.8%), poor results of laboratory tests (SGOT, SGPT), patients with all level of hepatic function based on Child-Pugh classification and staging B of the tumor (70.5%). Patients with normal AFP ≤20 ng/ml were dominated by female patients, with the most common etiology of fatty liver and others, and with BCLC A and C staging. Descriptively, there was no difference in AFP level based on the number of nodules and size of tumor. Conclusion: The most common patients with high AFP level are those who have hepatitis B as etiology, younger age, male gender, high SGOT level and BCLC B staging. Meanwhile, patients with normal AFP level dominated with female and non-hepatitis patients. In this research, we found no differences of AFP level based on number and size of tumor descriptively.

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Section: Discussioncontrasting

confidence: 66%

Serum Afp (Alpha Feto Protein) Levels Profile of Hepatocellular Carcinoma Patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Putri

Maimunah

Retnowati

2022

MBIOM

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Estimation of telomerase, AFP, and AFP-L3 levels in Sudanese patients with hepatocellular carcinoma and chronic liver diseases

et al. 2018

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Plasma CD24 level as a promising prognostic biomarker of hepatocellular carcinoma

Rasmy,

Awad,

Mohamed

et al. 2024

Egypt Liver Journal

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Background Hepatocellular carcinoma constitutes the most common primary hepatic cancer and remains a major medical burden in both developing and developed world. It ranks fifth in terms of global cases and second in terms of deaths for males.CD24 is known as a heavily glycosylated cell surface molecule that is highly expressed in a wide variety of human malignancies. It plays an important role in self-renewal, proliferation, migration, invasion, and drug resistance. The aim of this work was to evaluate the potential role of serum CD24 in the diagnosis and prediction of response to interventional therapy among hepatocellular carcinomas. Methods This study included 40 adult Egyptian patients who had liver cirrhosis and hepatocellular carcinoma (HCC group). Another group of 20 patients with liver cirrhosis only served as controls (Cirrhosis group). All patients underwent standard laboratory tests and abdominal ultrasound. For HCC patients, a triphasic CT scan, alpha-fetoprotein was done. CD24 levels were measured in all patients, and in HCC patients at baseline and one month after intervention. Results Baseline CD24 was significantly higher among HCC group in comparison to cirrhosis group (19.463 ± 8.573 vs. 0.725 ± 0.125 mg/L) with an overall p value < 0.001. Serum CD24 levels significantly declined after locoregional treatment from 19.463 ± 8.573 mg/L to 3.569 ± 1.248 mg/L (p < 0.001). Baseline CD24 was a useful marker in eligibility for HCC intervention with 80% sensitivity and 74.29% specificity at a cutoff of ≤ 23 mg/L, and it also had 62.96% sensitivity and 100% specificity in prediction of cure after locoregional treatment at a cutoff of ≤ 19.5 mg/L. Conclusion CD24 could be a helpful diagnostic and prognostic marker for HCC, as its baseline level is useful in predicting both eligibility for intervention and cure after locoregional treatment.

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Assessment of Lens Culinaris Agglutinin-Reactive Fraction of Alpha Fetoprotein as an Early Diagnostic Marker for Hepatocellular Carcinoma among Sudanese Patients with Chronic Liver Disease

Cited by 3 publications

References 23 publications

Serum Afp (Alpha Feto Protein) Levels Profile of Hepatocellular Carcinoma Patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Serum Afp (Alpha Feto Protein) Levels Profile of Hepatocellular Carcinoma Patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Estimation of telomerase, AFP, and AFP-L3 levels in Sudanese patients with hepatocellular carcinoma and chronic liver diseases

Plasma CD24 level as a promising prognostic biomarker of hepatocellular carcinoma

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