Assessment of liver and renal functions in human immunodeficiency virus-infected persons on highly active antiretroviral therapy: A mixed cohort study

Mahajan, Vikram K.; Wadhwa, Dhaarna; Sharma, Aditi; Chauhan, Shailja; Vashist, Sanket; Kumar, Parveen; Chowdhry, Bhumika

doi:10.4103/ijdvl.ijdvl_169_18

Cited by 3 publications

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“…The demographic profile of HIV-affected individuals in this study was similar to what has been described in the past [6,22]. The prevalence of anemia ranged between 10% to 28% in asymptomatic HIV-infected individuals in the pre-AIDS stage and 71-92% in those with AIDS across countries [6,[9][10][11]13]. In general, the prevalence of anemia was higher in those ARTnaïve than those on ART, and severity varied from mild to severe [4,9,[11][12][13].…”

Section: Discussionsupporting

confidence: 82%

“…Anemia is an important cause of morbidity in HIVinfected individuals around the world, irrespective of highly active ART, which significantly improves quality of life and prevents the progression of HIV disease [2,3]. The acceleration of the disease, a decreased life expectancy, impaired physical function, the risk of ART-associated hepatotoxicity, psychological distress, and poor quality of life are important consequences of HIV-associated anemia [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…However, the magnitude of these factors varies across regions depending upon socioeconomic and health conditions. Although the prevalence of anemia among the HIV-affected and the associated factors remain understudied in the Indian context, it was 23% to 61.5% in some studies, irrespective of their ART status [6,[18][19][20]. Since the management of anemia in these individuals improves survival and the overall quality of life, we performed this study with the aim to assess the prevalence of anemia and the associated factors in HIVinfected individuals under follow-up in this part of the country having a low prevalence of HIV/AIDS and for an overall paucity of relevant data.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of anemia among HIV-infected individuals and the associated factors: A single-center, retrospective review of 513 cases

Mahajan¹,

Dhattarwal²,

Mehta³

et al. 2023

Our Dermatol Online

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Background: Although a major public health problem around the world, the prevalence of anemia and the associated factors in HIV-infected individuals remains understudied in the Indian context. Objectives: The objective was to assess the prevalence of anemia and the associated factors among HIV-infected individuals. Methods: The records of 513 HIV-affected individuals (M: F: 244:269) aged 12 to 84 years (mean ± SD: 37.5 ± 12.1) were reviewed retrospectively for the presence of anemia and the associated factors. The anemia was defined and severity was graded per the WHO guidelines. Results: Anemia of variable severity was present in 77.7% of the individuals. The female sex(OR: 2.09; Cl: 95%; CI: 1.41–3.10; p < 0.05), CD4+ count ≤ 200 cells/microliter (OR: 2.36; Cl: 95%; CI: 1.59–3.52; p < 0.0001), WBC count < 4000 cells/mm3 (OR: 3.29; Cl: 95%; CI: 0.97–11.14; p < 0.04), platelet count < 100,000 cells/dL (OR: 0.50; Cl: 95%; CI: 0.31–0.81; p < 0.05), before ART (OR: 3.78; Cl: 95%; CI: 2.91–4.91; p < 0.0001), and tuberculosis treatment (OR: 5.88; Cl: 95%; CI: 1.38–25.04; p < 0.05) were factors significantly associated with anemia. The mean duration of highly active antiretroviral therapy (ART) was 3.15 years, with 395 (77%) individuals being on treatment for ≤ five years. ART significantly improved hemoglobin levels (p < 0.0001). Conclusion: Anemia of variable severity remains a significant co-morbidity among HIV-infected individuals, especially females, prior to the initiation of ART, and those with a low CD4+ count or thrombocytopenia and on anti-tuberculosis treatment. The fact that this was a single-center study, its small number of subjects, the retrospective design, and no information on red blood cell indices and the viral load were its important limitations. Key words: AIDS; anemia; ART; CD4+ count; HAART; HIV; India

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of anemia among HIV-infected individuals and the associated factors: A single-center, retrospective review of 513 cases

Mahajan¹,

Dhattarwal²,

Mehta³

et al. 2023

Our Dermatol Online

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“…Drug-induced liver injury (DILI) results from the use of both prescription and non-prescription medication by HIV patients. 5 , 8 Antiretroviral therapy (ART) induced liver injury, is mainly induced by four mechanisms, mitochondrial toxicity, metabolic host-mediated injury, immune reconstitution, and hypersensitivity reactions. 9 DILI has to be considered a serious problem because the nature of the disease is unpredictable and probably fatal.…”

Section: Introductionmentioning

confidence: 99%

Chinese herbal medicine for drug-induced liver injury in patients with HIV/AIDS: A systematic review of randomized controlled trials

Zhang¹,

Li²,

Hou³

et al. 2023

Integrative Medicine Research

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Health-related quality of life among people living with HIV/AIDS on highly active antiretroviral treatment

Mahajan

Vashist

Mehta

et al. 2023

Indian Journal of Community and Family Medicine

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Introduction: The knowledge of the effect of sociodemographic and disease-related factors on health-related quality of life (HRQoL) among people living with HIV/AIDS (PLWHA) is important for planning comprehensive health-care services for them. Material and Methods: Two hundred PLWHA on antiretroviral therapy (ART) volunteered to complete a self-reported World Health Organization's Quality of Life[FIGURE DASH]HIV brief questionnaire (WHOQoL-HIV-BREF) that examines six domains each with four items (physical, psychological, level of independence, social, environmental, and spiritual) with 25 facets and additional 5 facets specific to PLWHA (symptoms of HIV, social inclusion, forgiveness, worries about the future, and death and dying). Results: Only 135 questionnaires from 73 (53.3%) men and 63 (46.7%) women (male: female – 1.14:1) aged 20–82 years (mean ± standard deviation: 42.9 ± 10.5 years) were found complete. Eighty-five (63%) individuals were aged 41–60 years, 78 (57.8%) individuals were matriculates, graduates, or postgraduates, 76 (56.3%) respondents were married, and 38 (28.1%) were widows/widowers. Staying-alone workers comprised 43 (31.8%) individuals. Overall health and HRQoL were rated satisfactory (n = 85.2%) and good/very good (n = 74.8%) by a significantly greater number of individuals (P = 0.001). Pearson's Chi-squared test showed no statistically significant (P > α) associations between good HRQoL and variables such as age >40 years, gender, education, marital status, duration of disease, disclosure of serostatus to family, ART for >3 years, and CD4 >200 cells/mL. Conclusion: Regular ART can result in adequate control of immunosuppression and no comorbidities in a majority of PLWHA, family and social acceptance, and financial security can result in overall good HRQoL in all six domains within the WHOQoL-HIV-BREF. The study is limited by its cross-sectional study design and small sample size.

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Assessment of liver and renal functions in human immunodeficiency virus-infected persons on highly active antiretroviral therapy: A mixed cohort study

Cited by 3 publications

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Prevalence of anemia among HIV-infected individuals and the associated factors: A single-center, retrospective review of 513 cases

Prevalence of anemia among HIV-infected individuals and the associated factors: A single-center, retrospective review of 513 cases

Chinese herbal medicine for drug-induced liver injury in patients with HIV/AIDS: A systematic review of randomized controlled trials

Health-related quality of life among people living with HIV/AIDS on highly active antiretroviral treatment

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