Assessment of liver fibrosis by Fibroscan as compared to liver biopsy in biliary atresia

Shen, Qiulong; Chen, Yajun; Wang, Zengmeng; Zhang, Tingchong; Pang, Wenbo; Shu, Jun; Peng, Chunhui

doi:10.3748/wjg.v21.i22.6931

Cited by 65 publications

(64 citation statements)

References 24 publications

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“…In a study that included 106 Japanese patients with hepatitis C, cut-off values of M2BP for four fibrosis stages (F1–F4) ranged from 1.0 to 2.64 [31]. In another Japanese study performed on 137 primary biliary cirrhosis patients, performances were better than ours, with AUCs for significant fibrosis, severe fibrosis, and cirrhosis of 0.979, 0.933, and 0.965, respectively, and the cut off values for M2BPGi in fibrosis stages > F1, >F2, >F3, and > F4 were 0.7, 1.0, 1.4, and 2.0, respectively [14]. In our study, M2BPGi did not perform well for classifying patients at the extremes of significant and severe fibrosis (F2–F3).…”

Section: Discussionmentioning

confidence: 79%

Accuracy of M2BPGi, compared with Fibro Scan®, in analysis of liver fibrosis in patients with hepatitis C

Kong

Liu

et al. 2017

BMC Gastroenterol

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BackgroundMac-2 Binding Protein Glycosylation isomer (M2BPGi) is a novel serological glyco-biomarker for staging liver fibrosis. Here, we aimed to evaluate the efficiency of serum M2BPGi in identifying liver fibrosis stages in Chinese patients with chronic hepatitis C infection.MethodsSerum M2BPGi levels were evaluated in 680 patients with chronic hepatitis C and 164 healthy controls who underwent the Fibro Scan® test of liver fibrosis. The diagnostic accuracy of serum M2BPGi values was compared to that of other fibrosis markers, including Fibro Scan®, the aspartate transaminase to platelet ratio index (APRI), the fibrosis index based on four factors (FIB4), and the gamma-glutamyltranspeptidase to platelet ratio (GPR).ResultsAmong the chronic hepatitis C patients, the median serum M2BPGi level increased with increasing fibrosis score as follows: 0.88 (≤F2), 1.70 (F2/F3), and 5.68 (cirrhosis). M2BPGi concentrations could also distinguish between healthy controls (0.38 ± 0.24) and hepatitis C patients (1.57 ± 2.28). After adjusting for potential confounders, M2BPGi was the most significant factor associated with the liver stiffness measurement (effect size = 0.275, P < 0.001). The optimum cutoff values of serum M2BPGi for patients with F2 and F4 were 0.945 and 1.355, respectively. The area under the curve of serum M2BPGi for prediction of significant fibrosis (F ≥ 4) using was comparable to that of APRI (0.892 vs. 0.873), while it was superior to that of other alternative markers, including FIB4 (0.818) and GPR (0.851). Compared with other non-invasive markers, M2BPGi had the greatest specificity for diagnosing cirrhosis and cirrhosis in hepatitis C patients.ConclusionsOur results suggest that the level of serum M2BPGi would be a simple and reliable diagnostic tool for identifying liver fibrosis stage in Chinese patients with chronic hepatitis.

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Section: Discussionmentioning

confidence: 79%

Accuracy of M2BPGi, compared with Fibro Scan®, in analysis of liver fibrosis in patients with hepatitis C

Kong

Liu

et al. 2017

BMC Gastroenterol

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“…Most of the studies that have compared liver biopsies with different elastographic methods were performed on an adult population; there are only few studies performed on children [18]. A recent paediatric study compared TE with liver biopsies in a cohort of children with chronic C hepatitis, in order to elaborate the specific cut off values for this technique in paediatric patients [19], and another paediatric study focused on the performance of TE for evaluating liver fibrosis in infants with biliary atresia [20].…”

Section: Discussionmentioning

confidence: 99%

Comparison of three ultrasound based elastographic techniques in children and adolescents with chronic diffuse liver diseases.

et al. 2016

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Non-invasive techniques for liver fibrosis assessment were developed for adults and recent researches tested their accuracy in children. The only validated elastographic method for non-invasive liver fibrosis evaluation in children is Transient Elastography (TE). The aim of our study was to investigate the feasibility of liver stiffness (LS) measurement in paediatric patients with chronic liver diseases by means of Acoustic Radiation Force Impulse Elastography (ARFI) and 2D-Shear Wave Elastography (2D-SWE), compared to TE as reference method. Material and methods: We enrolled 54 consecutive children and adolescents with different chronic liver diseases. All patients were examined by means of TE, ARFI, and 2D-SWE. All measurements were performed in the right liver lobe, in the same session, in fasting condition. We considered reliable LS elastographic measurements as follows: for TE and ARFI -the median value of ten measurements with a success rate≥60% and an interquartile range<30%, for 2D-SWE -the median value of five measurements. Results: The successful measurement rate for TE was 94.4% (51/54). Taking TE as a reference method, sensitivity of ARFI for detecting fibrosis F1 was 71.42%, for F2-77.77%, for F3-62.5% and for F4-71.42%. Sensitivity of 2D-SWE for detecting F1 was 92.85%, for F2-83.33%, for F3-87.5% and for F4-85.71%. We found significant correlations between TE and 2D-SWE on the entire lot (Kappa correlation factor=0.843, p=0.001). Analyzing the subgroup with SR=60%-70%, we did not find significant correlation between TE and ARFI (Kappa correlation factor=0.172, p=0.452). Assessing the subgroup with SR>70%, we found a significant correlation between TE and ARFI (Kappa correlation factor=0.761, p=0.001). Conclusions: Overall, 2D-SWE correlate better with TE compared to ARFI in children. Excluding patients with less satisfactory technical parameters, we obtained significant correlations between all three methods. Both SWE and ARFI are non-invasive techniques feasible of performing on paediatric patients along with TE.

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“…BA patients are prone to developing liver fibrosis (LF) in early infancy, and the results of transient elastography (TE) correlate with LF status in BA patients . Thus, assessing liver stiffness in cholestatic infants may facilitate the differential diagnosis of BA.…”

mentioning

confidence: 99%

Transient elastography is useful in diagnosing biliary atresia and predicting prognosis after hepatoportoenterostomy

Lee

Lin

et al. 2018

Hepatology

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Assessment of liver fibrosis by Fibroscan as compared to liver biopsy in biliary atresia

Abstract: Fibroscan can be used as a non-invasive technique to assess liver fibrosis in children with BA. The cut-off value of LSM (15.15 kPa) can distinguish cirrhotic patients from non-cirrhotic patients.

Cited by 65 publications

References 24 publications

Accuracy of M2BPGi, compared with Fibro Scan®, in analysis of liver fibrosis in patients with hepatitis C

Accuracy of M2BPGi, compared with Fibro Scan®, in analysis of liver fibrosis in patients with hepatitis C

Comparison of three ultrasound based elastographic techniques in children and adolescents with chronic diffuse liver diseases.

Transient elastography is useful in diagnosing biliary atresia and predicting prognosis after hepatoportoenterostomy

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