Assessment of long distance chasing photometer (NAG-ADF-300-2) by estimating the drug atenolol with ammonium molybdate via continuous flow injection analysis

Abstract

Atenolol was used with ammonium molybdate to prove the efficiency, reliability and repeatability of the long distance chasing photometer (NAG-ADF-300-2) using continuous flow injection analysis. The method is based on reaction between atenolol and ammonium molybdate in an aqueous medium to obtain a dark brown precipitate. Optimum parameters was studied to increase the sensitivity for developed method. A linear range for calibration graph was 0.1-3.5 mmol/L for cell A and 0.3-3.5 mmol/L for cell B, and LOD 133.1680 ng/100 µL and 532.6720 ng/100 µL for cell A and cell B respectively with correlation coefficient (r) 0.9910 for cell A and 0.9901 for cell B, RSD% was lower than 1%, (n=8) for the determination of atenolol at concentration (0.5, 0.7 and 5) mmol/L respectively. The results were compared with classical method UV-Spectrophotometric at λ max=270 nm using the standard addition method via the use of t-test, at 95% confidence level. The comparison of data explain that long distance chasing photometer (NAG-ADF-300-2) is the choice with excellent extended detection and wide application.

Fast New Method for Estimation of Captopril in Pure and Pharmaceutical Preparation by Reaction with Ammonium Ce (IV) Sulfate in Acid Medium

“…Analytical systems by flow injection are more suitable for everyday use in quality control laboratories for the production of pharmaceutical preparations due to their simplicity of work, speed, sensitivity, and less consumption of reagents, sample samples, and other chemicals when compared to other methods of chemical analysis. This study describes a simple, sensitive, fast, low-contamination, easy-to-operate analytical method for determining CAP within the continuous flow injection analysis (CFIA) technique [34][35][36][37][38][39][40]. Captopril was estimated after its interaction with ammonium by studying the precipitate formed as a result of the oxidation of CAP in an acidic medium using homemade Ayah 6SX1-ST-2D solar cell CFI analyzer [41], which was used in previous studies for the determination of some drugs [42][43][44][45][46][47].…”