Assessment of Long Distance Chasing Photometer (NAG-ADF-300-2) by Estimating the Drug Atenolol with Povidone Iodine Via CFIA

Mezaal, Elham N.

doi:10.30526/33.1.2383

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Analytical systems by flow injection are more suitable for everyday use in quality control laboratories for the production of pharmaceutical preparations due to their simplicity of work, speed, sensitivity, and less consumption of reagents, sample samples, and other chemicals when compared to other methods of chemical analysis. This study describes a simple, sensitive, fast, low-contamination, easy-to-operate analytical method for determining CAP within the continuous flow injection analysis (CFIA) technique [34][35][36][37][38][39][40]. Captopril was estimated after its interaction with ammonium by studying the precipitate formed as a result of the oxidation of CAP in an acidic medium using homemade Ayah 6SX1-ST-2D solar cell CFI analyzer [41], which was used in previous studies for the determination of some drugs [42][43][44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Fast New Method for Estimation of Captopril in Pure and Pharmaceutical Preparation by Reaction with Ammonium Ce (IV) Sulfate in Acid Medium

Jabbar,

Mezaal

2024

IHJPAS

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The determination of captopril (CAP) using a new continuous flow injection analysis (CFIA) method was given in this work CAP in its pure state and some of its pharmaceutical preparations. The technique can be described as simple, fast, sensitive, easy to operate, and low-cost. The CAP reacted with ammonium ceric(IV) sulfate (ACS)2(NH4 )2SO4Ce(SO4)2. 3 H2O in an acidic medium and the reaction led to the formation of a white, slightly yellowish precipitate. The formed precipitate was studied using Ayah 6S×1-ST-2D Solar cell-CFI Analyzer, a through the reflection of accident light on the surfaces of the precipitate particles at (0-1800), expressed as the response of the transducer measured in (mV). Some chemical and physical parameters were studied to provide the optimal conditions for the study. The calibration curve within the range of (0.07-3.0) mmol/L was linear, with a correlation coefficient (r) value equal to (0.9983), and the percentage value of linearity (R2%) was (99.65). The method's detection limit (L.O.D.) of the new method was 272.5 ng/25 µL; it was calculated by diluting the minimum concentration in the calibration curve gradually. RSD% was less than 0.2% for 0.9, 1.5, and 3.0 mmol/L concentrations of C.A.P. for n=8. The method was successfully applied to estimate C.A.P. in three pharmaceutical preparations, each produced by a different company. The new method was compared with the UV-Spectrophotometric method (classical method) at λmax= 207.2 nm by using the method of standard additions. Both the t-test and the F-test were conducted to ensure that there wasn't a significant difference between the new method and the conventional one. The results of both tests showed, at a confidence level of 95%, that there was no significant difference.

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Section: Introductionmentioning

confidence: 99%

Fast New Method for Estimation of Captopril in Pure and Pharmaceutical Preparation by Reaction with Ammonium Ce (IV) Sulfate in Acid Medium

Jabbar,

Mezaal

2024

IHJPAS

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“…There are several methods for estimating diphenhydramine hydrochloride in literature; we mention some of them: spectrophotometric methods 6,7 , chromatographic methods [8][9][10][11] , flow injection 12,13 and potentiometric methods 14 . In this study, a new method was introduced within the continuous flow injection analysis technique [15][16][17][18] ,using homemade cells [19][20][21][22] , which depends on fluorescence or turbidity [23][24][25][26] as it is an easy, simple, sensitive, safe and inexpensive method to control the quality of DPH-containing drug tablets using homemade Ayah 6S×1-ST-2D solar cell CFI analyzer 27 , which has been successfully used in the determination of some drugs and some elements 28 . The study aims to present a simple, easy-to-work, environmentfriendly, low-cost, repeatable and high recovery percentage analytical method for diphenhydramine hydrochloride (DPH).…”

Section: Introductionmentioning

confidence: 99%

Continuous Flow Injection Analysis Method for the Determination of a Drug Diphenhydramine Hydrochloride by Using Phosphomolybdic Acid

Jabbar,

Mezaal

2024

Baghdad Sci.J

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The study presented a new method for determining diphenhydramine hydrochloride (DPH) in its pure form and some pharmaceutical preparations, within CFIA technique. The method is simple, fast, sensitive, easy to operate, and of a low cost. It is based on the reaction of DPH with phosphomolybdic acid (PMA), in aqueous media, forming a white, slightly yellowish precipitate. The precipitate formed was studied using an Ayah 6S×1-ST-2D solar cell CFI analyzer, by the reflection of incident light off the surfaces of the deposited particles at (0–180°), expressed as the response measured in (mV) . Some chemical and physical variables were studied to provide optimal conditions for the study. The linear range was 0.07-9 mmol/L and it had a correlation coefficient (r) with a value of (0.9998). The limit of detection (L.O.D.) of the new method was 729.55 ng/sample, calculated by gradually diluting the lower limit of the concentration in the linear range (0.07 mmol/L). The % RSD was less than 0.2% for a concentration of 0.1, 4.0 and 10.0 mmol/L of DPH for n = 8. The method was successfully applied in the determination of DPH in three samples from three different pharmaceutical production companies. Using the standard addition method, the new method was compared with the UV-Vis spectrophotometry method at λmax = 258 nm. Both T-test and F-test. The results of the two tests showed no significant difference at a confidence level (95%).

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Spectrophotometric determination of atenolol via oxidation and bleaching color reaction for methyl red dye

Zakaria

Othman

2021

J. Phys.: Conf. Ser.

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A selective and sensitive spectrophotometric method has been suggested for the quantitative assay of atenolol (ATNL) as pure and in its manufactural formulation(Tablet). The suggested procedure included oxidation of ATNL with an excess quantity of the oxidant N-bromosuccinimide (NBS), and then the excess of NBS was occupied in bleaching the color of methyl red dye(MRD), then measuring the absorbance of remaining MRD at 518 nm. The absorbance of the unbleached color of MRD corresponds to the ATNL concentration in the sample solution. Beer’s law was followed in the range of 0.1-2.0 μg.ml−1with molar absorptivity value equal to 8.8864x104 l.mol−1. cm−1. The suggested method was applied to the assay of ATNL in commercial tablets, with satisfactory results.

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Assessment of Long Distance Chasing Photometer (NAG-ADF-300-2) by Estimating the Drug Atenolol with Povidone Iodine Via CFIA

Cited by 4 publications

References 15 publications

Fast New Method for Estimation of Captopril in Pure and Pharmaceutical Preparation by Reaction with Ammonium Ce (IV) Sulfate in Acid Medium

Fast New Method for Estimation of Captopril in Pure and Pharmaceutical Preparation by Reaction with Ammonium Ce (IV) Sulfate in Acid Medium

Continuous Flow Injection Analysis Method for the Determination of a Drug Diphenhydramine Hydrochloride by Using Phosphomolybdic Acid

Spectrophotometric determination of atenolol via oxidation and bleaching color reaction for methyl red dye

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