Assessment of long-term psychosocial outcomes in anti-NMDA receptor encephalitis

Blum, Raia A.; Tomlinson, Amanda R.; Kwon, Churl‐Su; Easton, Ava; Yeshokumar, Anusha K.

doi:10.1016/j.yebeh.2020.107088

Cited by 38 publications

(54 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients may initially present to clinicians outside of neurology, such as psychiatry or internal medicine, which can delay prompt diagnosis and treatment. 7 , 8 In 1 multisite study, AE was initially suspected in only 32% of patients despite 80% of patients presenting with symptoms and signs typical of an immune-mediated neurologic disorder. 9 Even in tertiary care centers, there can be significant delays in diagnosis, contributing to delays in treatment and prolongation of hospital stay.…”

Section: Initial Diagnosismentioning

confidence: 99%

“…Collaboration between neurologists and mental health clinicians during hospitalization, at discharge, and throughout outpatient treatment is fundamental and can have a far-reaching effect on outcomes in AE cohorts. 8 …”

Section: Multidisciplinary Follow-upmentioning

confidence: 99%

“…In particular, cognitive impairment and psychiatric/behavioral sequelae complicate recovery and contribute to morbidity. 8 , 36 Evidence citing “good outcomes” in AE is commonly defined as an mRS score of ≤2, which offers a very broad range in recovery as the scale is heavily weighted toward motor function. This measure neglects more meaningful outcomes such as resumption of gainful employment or schooling and establishment of personal relationships.…”

Section: Long-term Prognosismentioning

confidence: 99%

“…Nearly one-third did not resume their prior work or schooling after their illness, whereas 20% of patients required special accommodations because of persistent deficits. 8 , 37 …”

Section: Long-term Prognosismentioning

confidence: 99%

See 3 more Smart Citations

Autoimmune Neurology

Abbatemarco

Day

Titulaer

et al. 2021

Neurol Neuroimmunol Neuroinflamm

Self Cite

View full text Add to dashboard Cite

Autoimmune neurology is a rapidly developing specialty driven by an increasing recognition of autoimmunity as the cause for a broad set of neurologic disorders and ongoing discovery of new neural autoantibodies associated with recognizable clinical syndromes. The diversity of clinical presentations, unique pathophysiology, and the complexity of available treatments requires a dedicated multidisciplinary team to diagnose and manage patients. In this article, we focus on antibody-associated autoimmune encephalitis (AE) to illustrate broader themes applicable to the specialty. We discuss common diagnostic challenges including the utilization of clinical assessment tools along with the determination of the prognostic significance of certain autoantibodies, with a focus on implications for long-term management. A growing body of literature demonstrates the long-term cognitive, behavioral, and physical sequelae of AE. Dedicated resources are needed to effectively manage these patients. These resources may be best provided by experienced neurology clinics in partnership with other neurologic subspecialists, as well as psychiatrists, neuropsychologists, and physical medicine and rehabilitation providers.

show abstract

Section: Initial Diagnosismentioning

confidence: 99%

Section: Multidisciplinary Follow-upmentioning

confidence: 99%

Section: Long-term Prognosismentioning

confidence: 99%

“…Nearly one-third did not resume their prior work or schooling after their illness, whereas 20% of patients required special accommodations because of persistent deficits. 8 , 37 …”

Section: Long-term Prognosismentioning

confidence: 99%

See 2 more Smart Citations

Autoimmune Neurology

Abbatemarco

Day

Titulaer

et al. 2021

Neurol Neuroimmunol Neuroinflamm

Self Cite

View full text Add to dashboard Cite

show abstract

“…Long‐term prognosis varies considerably across the AE spectrum, and neuropsychiatric outcomes incorporate depressive and anxiety symptomology. In addition, psychological concerns also include symptoms of adjustment disorder and challenges to personal identity 69,70 …”

Section: Chronic Psychopathologymentioning

confidence: 99%

Cognition and psychopathology in autoimmune encephalitides: A focus on risk factors and patient outcomes

Griffith

Malpas

Kyndt

et al. 2021

Clinical & Exp Neuroim

View full text Add to dashboard Cite

Neurocognitive compromise, neuropsychiatric symptoms and psychopathology are all evident in the acute stages of autoimmune encephalitides. These factors considerably affect functional independence after discharge. Drawing on psychometric assessments and qualitative descriptions, this review explores the nature, extent and diagnosis of cognitive disorder in autoimmune encephalitides. Potential pathophysiological and neuroanatomical architecture related to neurocognitive compromise in the acute and chronic stages of this illness is examined. In regard to outcomes, the review highlights clinicodemographic factors currently known to be associated with poorer cognitive outcome. Finally, the review delves into neuropsychiatric symptomology and psychological concerns that should be considered at diagnosis and during follow up of these patients.

show abstract

Enzephalitiden

Finke,

Easton

2024

NeuroRehabilitation

View full text Add to dashboard Cite

Assessment of long-term psychosocial outcomes in anti-NMDA receptor encephalitis

Cited by 38 publications

References 39 publications

Autoimmune Neurology

Autoimmune Neurology

Cognition and psychopathology in autoimmune encephalitides: A focus on risk factors and patient outcomes

Enzephalitiden

Contact Info

Product

Resources

About