Assessment of long-term quality of life in patients with orthotopic neobladder followed for more than 5 years

Takenaka, Atsushi; Hara, Isao; Soga, Hideo; Sakai, Iori; Taguchi, Tomoaki; Muramaki, Mototsugu; Miyake, Hideaki; Tanaka, Kazushi; Fujisawa, Masato

doi:10.1007/s11255-010-9851-3

Cited by 24 publications

(28 citation statements)

References 21 publications

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“…These findings are in line with the results of Takenaka et al who evaluated long-term outcome in QoL after orthotopic neobladder in 86 patients and found worse QoL scores in patients with daytime incontinence (36). Zahran et al analyzed QoL of 74 women after radical cystectomy and orthotopic neobladder using QLQ-C30 and observed a significant negative impact of incontinence (7).…”

Section: Discussionsupporting

confidence: 91%

Prognostic features for quality of life after radical cystectomy and orthotopic neobladder

et al. 2016

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Purpose:To analyse prognostic features on quality of life (QoL) following radical cystectomy and urinary diversion via orthotopic neobladder in a single-centre patient cohort.Materials and Methods:Postoperative QoL of 152 patients was assessed retrospectively using the validated QLQ-C30 questionnaire. Potential associations of patient's quality of life including pre-and intraoperative characteristics, surgeon experience, postoperative time course, adjuvant therapies, and functional outcome were defined a priori and evaluated. Mann-Whitney-U-, Kruskal-Wallis-, Spearman correlation and post hoc-testing were used. A multivariate analysis using a multiple logistic regression model was performed. A p value <0.05 was considered to be statistically significant.Results:Median follow-up was 48 months. Univariate analysis of prognostic features for health-related QoL revealed a significant impact of gender (p=0.019), performance status (p<0.001), experience of surgeon (>100 previous cystectomies, p=0.007), and nerve-sparing surgery (p=0.001). Patients who underwent secondary chemotherapy or radiotherapy had significant lower QLQ-C30 scores (p=0.04, p=0.02 respectively). Patients who were asymptomatic had a significantly higher quality of life (p<0.001). A significant impact of severity of incontinence based on ICIQ-SF score (p<0.001) and daily pad usage (p<0.001), existence of daytime incontinence (p<0.001), existence of urgency symptoms (p=0.007), and IIEF-5 score (p<0.001) could be observed. In multivariate analysis, independent prognostic relevance could be confirmed for preoperative ECOG performance status of 0 (p=0.020 vs. ECOG 1, p=0.047 vs. ECOG 2), experience of the respective surgeon (≥100 vs. <100 previous cystectomies, p=0.021), and daytime continence (p=0.032).Conclusion:In the present study, we report health-related QoL outcomes in a contemporary patient cohort and confirm preoperative ECOG status, surgeon experience and daytime incontinence as independent prognostic features for a good postoperative QoL.

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Section: Discussionsupporting

confidence: 91%

Prognostic features for quality of life after radical cystectomy and orthotopic neobladder

et al. 2016

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“…However, QOL has not been sufficiently assessed in non-metastatic bladder cancer patients (NMBC) (6). Therefore, available data on the comparison of the impact of different treatments on the QOL of NMBC patients are limited (7). The MOS 36-item Short-Form Health Survey (SF-36) score is extensively used worldwide and is considered to be accurate (8–11).…”

Section: Introductionmentioning

confidence: 99%

Impact of invasive bladder cancer and orthotopic urinary diversion on general health-related quality of life: An SF-36 survey

Mingying

Wang

et al. 2013

Molecular and Clinical Oncology

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Bladder cancer is a common type of genitourinary cancer, and radical cystectomy with urinary diversion is considered to be the most effective local treatment for invasive bladder cancer. In order to assess the functional results and health-related quality of life (QOL) in bladder cancer patients with an orthotopic neobladder, and to provide a reasonable basis for the evaluation of urinary diversion in situ, we conducted a study on 96 neobladder patients. In December, 2011, questionnaires were mailed to 96 patients that had undergone urinary diversion surgery between January, 2007 and December, 2009. The questionnaire included the validated health-related QOL questionnaire and the MOS 36-item Short-Form Health Survey (SF-36). We compared the functional results between patients with an orthotopic neobladder and those with other types of urinary diversion at 6, 12 and 24 months after surgery. Data from 82 patients (54 with orthotopic and 28 with non-orthotopic urinary diversion) were included in the analysis. The SF-36 patient scores following orthotopic urinary diversion were significantly higher than those following non-orthotopic urinary diversion. The majority of patients with orthotopic urinary diversion considered themselves as healthy and their scores of total health were higher compared to those of patients with non-orthotopic urinary diversion. However, there were no differences in the scores of physical functioning between patients with orthotopic and those with non-orthotopic urinary diversion. Our findings regarding health-related QOL and the frequency of complications in the orthotopic and the non-orthotopic urinary diversion groups were similar. However, the mental health of patients with orthotopic urinary diversion was more easily restored compared to that of patients with non-orthotopic urinary diversion, which reduced their overall recovery time.

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“…The need of clean intermittent self catheterization (CIC) and the presence of incontinence significantly impaired QOL . In the present study two patients required CIC sometimes for evacuation of urine.…”

Section: Discussionmentioning

confidence: 83%

Short‐Term Functional and Urodynamic Outcome of W‐ileal Orthotopic Neobladder with Serosa‐Lined Tunneled Uretero‐Ileal Anastomosis

Barapatre

Agarwal

Mavuduru

et al. 2013

LUTS

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Assessment of long-term quality of life in patients with orthotopic neobladder followed for more than 5 years

Abstract: Although GH-QOL was generally well maintained, the presence of CIC or daytime incontinence impaired GH-QOL. Most were not satisfied with their level of sexual function 5 years after orthotopic neobladder construction.

Cited by 24 publications

References 21 publications

Prognostic features for quality of life after radical cystectomy and orthotopic neobladder

Prognostic features for quality of life after radical cystectomy and orthotopic neobladder

Impact of invasive bladder cancer and orthotopic urinary diversion on general health-related quality of life: An SF-36 survey

Short‐Term Functional and Urodynamic Outcome of W‐ileal Orthotopic Neobladder with Serosa‐Lined Tunneled Uretero‐Ileal Anastomosis

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