Assessment of longitudinal systolic function using tissue motion annular displacement in healthy dogs

Wolf, Marcela; Lucina, Stephany Buba; Brüler, Bruna Cristina; Tuleski, Giovana Laís Ruviaro; Silva, Vinícius B.C.; Sousa, Marlos Gonçalves

doi:10.1016/j.jvc.2018.04.004

Cited by 17 publications

(21 citation statements)

References 33 publications

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“…Third, TMAD presents significant correlations with many conventional LV systolic function parameters. In both animal and human researches, TMAD has been significantly correlated with LVEF and GLS [ 38 – 40 ]. Consistent with previous literature, we detected significant correlations between TMAD and LVEF.…”

Section: Discussionmentioning

confidence: 99%

Feasibility and discriminatory value of tissue motion annular displacement in sepsis-induced cardiomyopathy: a single-center retrospective observational study

et al. 2022

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Background There is no formal diagnostic criterion for sepsis-induced cardiomyopathy (SICM), but left ventricular ejection fraction (LVEF) < 50% was the most commonly used standard. Tissue motion annular displacement (TMAD) is a novel speckle tracking indicator to quickly assess LV longitudinal systolic function. This study aimed to evaluate the feasibility and discriminatory value of TMAD for predicting SICM, as well as prognostic value of TMAD for mortality. Methods We conducted a single-center retrospective observational study in patients with sepsis or septic shock who underwent echocardiography examination within the first 24 h after admission. Basic clinical information and conventional echocardiographic data, including mitral annular plane systolic excursion (MAPSE), were collected. Based on speckle tracking echocardiography (STE), global longitudinal strain (GLS) and TMAD were, respectively, performed offline. The parameters acquisition rate, inter- and intra-observer reliability, time consumed for measurement were assessed for the feasibility analysis. Areas under the receiver operating characteristic curves (AUROC) values were calculated to assess the discriminatory value of TMAD/GLS/MAPSE for predicting SICM, defined as LVEF < 50%. Kaplan–Meier survival curve analysis was performed according to the cutoff values in predicting SICM. Cox proportional hazards model was performed to determine the risk factors for 28d and in-hospital mortality. Results A total of 143 patients were enrolled in this study. Compared with LVEF, GLS or MAPSE, TMAD exhibited the highest parameter acquisition rate, intra- and inter-observer reliability. The mean time for offline analyses with TMAD was significantly shorter than that with LVEF or GLS (p < 0.05). According to the AUROC analysis, TMADMid presented an excellent discriminatory value for predicting SICM (AUROC > 0.9). Patients with lower TMADMid (< 9.75 mm) had significantly higher 28d and in-hospital mortality (both p < 0.05). The multivariate Cox proportional hazards model revealed that BMI and SOFA were the independent risk factors for 28d and in-hospital mortality in sepsis cases, but TMAD was not. Conclusion STE-based TMAD is a novel and feasible technology with promising discriminatory value for predicting SICM with LVEF < 50%.

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Section: Discussionmentioning

confidence: 99%

Feasibility and discriminatory value of tissue motion annular displacement in sepsis-induced cardiomyopathy: a single-center retrospective observational study

et al. 2022

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“…Some echocardiographic parameters used for assessment of left ventricular systolic function, in particular TMAD (mm/kg and mm/m²), were higher in responsive dogs before and after fluid challenge (Figure 5). TMAD is part of an advanced echocardiographic examination but is widely studied in individuals with heart disease to assess longitudinal myocardial fibers [6,10,17,29,30]. This group of muscle fibers seems to be the first to be affected in systolic dysfunction [16].…”

Section: Discussionmentioning

confidence: 99%

Conventional vs. Advanced Echocardiographic Parameters for Predict Fluid Responsiveness in Healthy Dogs

Lucina

Muehlbauer

Silva

et al. 2022

Acta Scientiae. Vet.

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Background: Volume replacement is considered an essential component in the treatment of critically ill patients, but excess fluid administration can be as harmful as the lack of fluid therapy. Therefore, the volume replacement is only beneficial in patients deemed to be fluid responsive, that is, when the individual has an increase in their stroke volume after administration of a volume challenge. This study aim to assess whether conventional and advanced echocardiographic parameters for assessing left ventricular systolic function are able to predict fluid responsiveness in healthy spontaneously breathing dogs. The hypothesis was that some of these parameters would differ between responsive and non-responsive animals and could be used as a complementary measure for assessment of fluid responsiveness.Materials, Methods & Results: A prospective study was carried out in which 22 client-owned healthy dogs over 1 year of age that presented to the Veterinary Medical Teaching Hospital for elective neutering procedure were included. All dogs underwent conventional and advanced echocardiographic examination to obtain the left ventricular internal diameter in diastole normalized (LVIDDn), left ventricular internal diameter in systole normalized (LVIDSn), ejection fraction (EF) and shortening fraction (SF) according to the Teischholz methodology, global longitudinal strain (GLS) and tissue motion annular displacement (TMAD). There parameters were evaluated before and after administration of a volume challenge with 10 mL/kg lactate ringer intravenously for 20 min. Based on the variation in aortic velocity integral time, 31.82% of dogs were considered responsive and 68.18% were non-responsive to the volume challenge. For advanced echocardiography, TMAD indexed by body weight (mm/kg) > 0.89 (P = 0.004) and body surface area (mm/m2) >18.9 (P = 0.004) after volume challenge had the best area under the curve values (both 0.895) and smaller gray zone intervals (0.52 - 0.81 and 14.89 - 17.88) for the identification of responsive dogs. Although, TMAD (mm/kg and mm/m2) before volume challenge was also higher in the responsive dogs (P = 0.041 and P = 0.029). As for conventional echocardiography, the LVIDDn < 1.39 (P = 0.003) before volume challenge had the best area under the curve value (0.866) and the smallest gray zone interval (1.4 - 1.57) for the identification of responsive dogs. The GLS and the TMAD in milimeters (mm), percentage (%) and indexed by cubic root of weight (mm/∛kg) did not differ between the responsive and non-responsive dogs before and after volume challenge.Discussion: TMAD indexed by body weight (mm/kg) and body surface area (mm/m2) before and after volume challenge and the LVIDDn before volume challenge may be useful measures to complement the assessment of fluid responsiveness in spontaneously breathing dogs. This is the first study to use TMAD as a predictive parameter for fluid responsiveness in healthy, spontaneously breathing, dogs. Even it is an advanced echocardiographic technique, TMAD has advantages interms of execution time and the fact that it is less dependence on image quality or operator experience. It is possible that in the future such variables may form a useful part of the evaluation of fluid responsiveness in dogs. However, more studies are needed to better understand the applicability of these techniques, especially in dogs with hemodynamic changes. Keywords: canine, global longitudinal strain, stroke volume, tissue motion annular displacement, TMAD, VTI.

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“…It corresponds to the time (ms) from the beginning of the QRS complex to the end of the aortic valve spectra obtained with the pulsed Doppler gate positioned distally to the valve. 24 The hinge points of mitral valve leaflets (septal and lateral) and the LV apex epicardial region were the three regions of interest (ROIs) used to calculate the LV LSt 25 (Figure 1a), which was measured automatically by the equipment software (QLAB ACMQ; Auto Cardiac Motion Quantification). Manual corrections were made whenever the automatic myocardial tracking was obviously incorrect.…”

Section: Systolic Functionmentioning

confidence: 99%

Timolol 0.5% ophthalmic solution influences cardiac function in healthy cats

Tuleski

Pscheidt²,

Santos

et al. 2022

Journal of Feline Medicine and Surgery

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Objectives The aim of this study was to ascertain the effect of a drop of timolol 0.5% ophthalmic solution on the systolic function of the left ventricle (LV) and left atrium (LA), and to confirm if timolol helped appraisal of diastolic function by reducing heart rate (HR) and separating the transmitral outflow waves from tissue Doppler imaging (TDI). Methods A total of 41 client-owned healthy cats underwent two echocardiograms 20 mins apart. The timolol group (33 cats) received a drop of timolol solution after the first examination. Standard and speckle-tracking echocardiography evaluated the LV and LA function of both groups at the two time points evaluated. Results Timolol reduced HR (19%), and fractional shortening from LV (20.3%) and LA (16.6%). Septal S' decreased by 51% (from 7.7 to 5.2 cm/s) and lateral S’ dropped by 43.1% (7.3 to 5.1 cm/s). Most longitudinal techniques did not change after timolol, including the mitral annular plane systolic excursion from the interventricular annulus, tricuspid annular plane systolic excursion, LV longitudinal strain and LV tissue motion annular displacement. The isovolumic relaxation time increased by 15.2% (from 54 to 64.6 ms), with most cats presenting this variable above the reference (>60 ms). Timolol did not support diastolic assessment, enabling evaluation in only 2/11 cats when using lateral TDI and 1/9 cats using septal TDI. Regarding side effects, miosis occurred in 18 cats (54.5%). Conclusions and relevance Timolol reduced systolic function, decreasing standard echocardiographic variables. Regarding diastolic evaluation, although timolol decreased HR, it did not separate the mitral diastolic waves, as expected.

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Assessment of longitudinal systolic function using tissue motion annular displacement in healthy dogs

Cited by 17 publications

References 33 publications

Feasibility and discriminatory value of tissue motion annular displacement in sepsis-induced cardiomyopathy: a single-center retrospective observational study

Feasibility and discriminatory value of tissue motion annular displacement in sepsis-induced cardiomyopathy: a single-center retrospective observational study

Conventional vs. Advanced Echocardiographic Parameters for Predict Fluid Responsiveness in Healthy Dogs

Timolol 0.5% ophthalmic solution influences cardiac function in healthy cats

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