Assessment of LV diastolic dysfunction in myocardial perfusion imaging: a correlative study with transthoracic echocardiography

Malek, Hadi; Samiei, Niloufar; Yaghoobi, Nahid; Bavaghar, Nafiseh; Firoozabadi, Hassan; Rastgou, F; Bakhshande, Hooman; Rajabi, Ahmad Bitarafan; Hedayati, Raheleh

doi:10.1097/mnm.0000000000001423

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…Yamano et al [ 20 ] compared LV diastolic function parameters measured by gated single-photon emission tomography with colour Doppler ultrasound, suggesting a moderate correlation between PFR and E, a significant correlation with E/e’ ratio. Malek et al [ 21 ] showed that myocardial perfusion imaging can be used as a highly specific means of detecting LV diastolic dysfunction compared with echocardiography. In the present study, we applied a correlation analysis between diastolic functional parameters obtained by planar MUGA and the average E/e’ ratio, showing that there was some correlation between PFR, TPF, PFR combined with TPF, and the average E/e’ ratio, but the correlation coefficients obtained in this study were small and larger sample size is needed of studies for further validation.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients

Liu

Zhou

et al. 2023

BMC Cardiovasc Disord

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Background In recent years, heart failure with preserved ejection fraction (HFpEF) has received increasing clinical attention. To investigate the diagnostic value of diastolic function parameters derived from planar gated blood-pool imaging (MUGA) for detecting HFpEF in coronary atherosclerotic heart disease (coronary artery disease, CAD) patients. Methods Ninety-seven CAD patients with left ventricular ejection fraction ≥ 50% were included in the study. Based on the left ventricular end-diastolic pressure (LVEDP), the patients were divided into the HFpEF group (LVEDP ≥ 16 mmHg, 47 cases) and the normal LV diastolic function group (LVEDP < 16 mmHg, 50 cases). Diastolic function parameters obtained by planar MUGA include peak filling rate (PFR), filling fraction during the first third of diastole (1/3FF), filling rate during the first third of diastole (1/3FR), mean filling rate during diastole (MFR), and peak filling time (TPF). Echocardiographic parameters include left atrial volume index (LAVI), peak tricuspid regurgitation velocity (peak TR velocity), transmitral diastolic early peak inflow velocity (E), average early diastolic velocities of mitral annulars (average e′), average E/e′ ratio. The diastolic function parameters obtained by planar MUGA were compared with those obtained by echocardiography to explore the clinical value of planar MUGA for detecting HFpEF. Results The Receiver-operating characteristic curve analysis of diastolic function parameters obtained from planar MUGA and echocardiography to detect HFpEF showed that: among the parameters examined by planar MUGA, the area under the curve (AUC) of PFR, 1/3FF, 1/3FR, MFR and TPF were 0.827, 0.662, 0.653, 0.663 and 0.809, respectively. Among the echocardiographic parameters, the AUCs for average e′, average E/e′ ratio, peak TR velocity, and LAVI values were 0.747, 0.706, 0.735, and 0.633. The combination of PFR and TPF showed an AUC of 0.856. PFR combined with TPF value demonstrated better predictive value than average e′ (Z = 2.020, P = 0.043). Conclusion Diastolic function parameters obtained by planar MUGA can be used to diagnose HFpEF in CAD patients. PFR combined with TPF was superior to the parameters obtained by echocardiography and showed good sensitivity and predictive power for detecting HFpEF.

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients

Liu

Zhou

et al. 2023

BMC Cardiovasc Disord

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“…In our study, the PFR showed the most significant correlation with the other functional parameters of G-SPECT MPI. Although the correlation of G-SPECT with other echocardiographic and angiographic techniques for evaluating diastolic function is acceptable [21], there are also reports of lower sensitivity of G-SPECT MPI [22,23]. However, it seems that the lower sensitivity of G-SPECT MPI is most commonly related to the detection of more advanced stages of diastolic function.…”

Section: Discussionmentioning

confidence: 99%

Characterization of left ventricular diastolic parameters of gated-single-photon emission computed tomography myocardial perfusion imaging in patients with diabetes and normal myocardial perfusion and systolic function

Ghaedian,

Abdinejad,

Aieneh

et al. 2023

Nuclear Medicine Communications

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Background Diabetic cardiomyopathy is defined as an independent entity with a specified pathological progression from diastolic dysfunction with preserved ejection fraction to overt heart failure. Myocardial perfusion imaging (MPI) with gated-single-photon emission computed tomography (G-SPECT) has been introduced as a feasible tool to evaluate left ventricular (LV) diastolic function. The aim of this study was to investigate the characteristics of diastolic parameters derived from G-SPECT MPI in diabetic patients compared to patients at very low risk of coronary artery disease (CAD) and with no other CAD risk factors. Methods This cross-sectional study was performed on patients referred to the nuclear medicine department for G-SPECT MPI. Demographic and clinical data, as well as medical history, were extracted from a digital registry system including 4447 patients. Then, two matched groups of patients with only diabetes as cardiac risk factor (n = 126) and those without any identifiable CAD risk factors (n = 126) were selected. Diastolic parameters of MPI, including peak filling rate, time to peak filling rate, mean filling rate at the first third of diastole and second peak filling rate, were derived using quantitative software for eligible cases. Results The mean age of the diabetic and nondiabetic groups was 57.1 ± 14.9 and 56.7 ± 10.6 years, respectively (P = 0.823). Comparison of quantitative SPECT MPI parameters between the two groups showed a statistically significant difference only in total perfusion deficit scores, whereas none of the functional parameters, including diastolic and dyssynchrony indices and the shape index, were significantly different. There were also no significant differences in diastolic function parameters between diabetes and nondiabetes patients in the age and gender subgroups. Conclusion Based on the G-SPECT MPI findings, there is a comparable prevalence of diastolic dysfunction in patients with only diabetes as a cardiovascular risk factor and low-risk patients with no cardiovascular risk factors in the setting of normal myocardial perfusion and systolic function.

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“…Ventricular diastolic dysfunction often precedes systolic dysfunction. Thus, even in asymptomatic patients, the evaluation of diastolic function is of great significance for patient prognosis and treatment strategies ( 26 ). There were no significant differences in the LVEF, EDV, ESV, and FV between the experimental group and the control group (P>0.05), indicating that there were no differences in left ventricular systolic function between the patients with HF and the normal controls.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the sensitivity and specificity of compressed sensing magnetic resonance imaging in the diagnosis of heart failure

An¹,

Qiu²,

Zhou³

et al. 2023

J Thorac Dis

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Background Magnetic resonance imaging (MRI) is a powerful tool for predicting heart failure (HF) patient prognosis (including death), but it adversely affecting clinical diagnosis and work efficiency. Compressed sensing technology reconstructs and recovers signals using sampling points that are far below the requirement of traditional sampling laws, which can shorten the signal acquisition time without affecting the image quality of MRI. This study aimed to apply compressed sensing technology to the MRI images of patients with HF to evaluate its effectiveness in the diagnosis of HF. Although compressed sensing MRI technology has not yet been widely adopted in clinical practice, it has demonstrated favorable application prospects. Through continuous updating and optimization, it is expected to become a research hotspot in medical imaging, providing more valuable information for clinical work. Methods In this study, 66 patients with acute ischemic stroke admitted to hospital were selected for the experimental group, and 20 patients with normal cardiac function who underwent physical examinations during the same period were selected for the control group. An MRI image reconstruction algorithm based on compressed sensing was developed and used in the cardiac MRI image processing. Results The results showed that the e’ and heart rate of the experimental group were significantly higher than those of the control group, and the E/e’ ratio was significantly lower than that of the control group (P<0.05). The early peak filling rate (PFR1), the PFR1/the late peak filling rate (PFR2), the early filling volume (FV1), and the FV1/the filling volume (FV) of the experimental group were significantly higher than those of the control group, and the PFR2 and the late filling volume (FV2) of the experimental group were significantly lower than those of the control group (P<0.05). The diagnostic sensitivity, specificity, and the area under the curve (AUC) for the concentration-time of the PFR2 were 0.891, 0.788, and 0.904, respectively. The diagnostic sensitivity, specificity, and AUC for the FV2 were 0.902, 0.878, and 0.925, respectively. The peak signal to noise ratio and structural similarity of the images reconstructed using the oral contraceptives algorithm were significantly higher than those determined by the sensitivity coding algorithm and the orthogonal matching pursuit algorithm (P<0.05). Conclusions The imaging algorithm based on compressed sensing had excellent processing effect on cardiac MRI and improved the image quality. Cardiac MRI imaging had good diagnostic performance for HF and had the value of clinical popularization.

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Assessment of LV diastolic dysfunction in myocardial perfusion imaging: a correlative study with transthoracic echocardiography

Cited by 5 publications

References 22 publications

Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients

Diagnostic value of parameters derived from planar MUGA for detecting HFpEF in coronary artery disease patients

Characterization of left ventricular diastolic parameters of gated-single-photon emission computed tomography myocardial perfusion imaging in patients with diabetes and normal myocardial perfusion and systolic function

Analysis of the sensitivity and specificity of compressed sensing magnetic resonance imaging in the diagnosis of heart failure

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