Assessment of macular choroidal and retinal thickness: a cohort study in Tibetan healthy children

Yao, Yao; Fu, Jing; Liu, Jiawen; Li, Lei; Chen, Weiwei; Meng, Zhaojun

doi:10.1038/s41598-024-51949-0

Cited by 3 publications

(2 citation statements)

References 48 publications

(56 reference statements)

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“…The data on such correlations vary among studies. Mansoori et al, Yao et al and Abbey et al reported a thinner central choroid and retina in longer eyeballs [ 19 , 20 , 21 ]. All of these studies used standard-field OCT scans.…”

Section: Discussionmentioning

confidence: 99%

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Choroidal and Retinal Thicknesses in Healthy Eyes Measured with Ultra-Wide-Field Optical Coherence Tomography

Kiciński,

Gawęcki

2024

Diagnostics

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Ultra-wide-field optical coherence tomography (UWF-OCT) has been recently introduced into clinical ophthalmological practice. To date, there are few data on the reference values of the retinal thickness (RT) and choroidal thickness (CT) measured with this technique. This study aimed to analyze the variance in RT and CT in the healthy eyes of white Caucasian patients with UWF-OCT tests performed with the largest available scan size of 23 × 20 mm. The data were analyzed with reference to the patients’ age and gender and the axial length of the eyeball. The results of UWF-OCT scanning enabled us to visualize the shape of the retina and choroid in a large portion of the eyeball. Both anatomical entities became significantly thinner at the periphery. The peripheral CT was greater in the upper and temporal sectors; the RT was higher in the nasal compared to the temporal sectors. Both the choroid and retina showed a reduced thickness with age; however, the CT and RT did not show a statistically significant correlation with the axial length after adjusting for age and gender. Age-related variations in thickness were especially prominent in the choroid. The CT in UWF-OCT testing was significantly greater in females, while the RT was greater in males. UWF-OCT testing provides additional information on the anatomical structure of the retina and choroid compared to standard-field OCT.

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Section: Discussionmentioning

confidence: 99%

“…The data on such correlations vary among studies. [19][20][21]. All of these studies used standard-field OCT scans.…”

Section: Axial Length and The Rt And Ctmentioning

confidence: 99%

Choroidal and Retinal Thicknesses in Healthy Eyes Measured with Ultra-Wide-Field Optical Coherence Tomography

Kiciński,

Gawęcki

2024

Diagnostics

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Evaluating retinal thickness classification in children: A comparison between pediatric and adult optical coherence tomography databases

Pua,

Hairol

2024

PLoS ONE

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Purpose This study investigates the agreement of children’s retinal thickness classification by color category between Topcon 3D OCT-1’s built-in adult reference data and our new pediatric database and assesses the correlation of retinal thickness with age and spherical equivalent (SE). Methods 160 eyes of 160 healthy children (74 boys, 86 girls) aged 6–18 years (mean: 11.60 ± 3.28 years) were evaluated in this cross-sectional study. The peripapillary retinal nerve fibre layer (pRNFL) and macular thickness were determined for the 1st, 5th, 95th, and 99th percentile points. Cohen’s κ value and specific agreement between pediatric data and adult reference database were estimated. The correlation between retinal thickness with age and SE was also determined. Results The mean thickness for the total RNFL, average macular, and central macula were 112.05±8.65 μm, 280.24±12.46 μm, and 220.55±17.53 μm, respectively. The overall agreement between the classification of the adult database and pediatric data for pRNFL was ≥90%, with discrepancies in 46 out of 150 eyes (30.67%); for macula, it was above 72%, with discrepancies in 93 out of 153 eyes (60.78%); and for ganglion cell complex and ganglion cell + inner plexiform layer (GCIPL) the agreement was above 84% and 85%, respectively. A significant level of agreement between pediatric data and adult reference data was achieved for temporal RNFL (κ = 0.65), macular perifoveal superior (κ = 0.67), and inferior (κ = 0.63) and inferior GCIPL (κ = 0.67). The correlations between age and retinal thickness were not significant (all p>0.05). Most retinal thickness parameters were positively associated with SE (Pearson’s coefficient, r = 0.26 to 0.49, all p<0.05). Conclusions The overall agreement for pRNFL and macular thickness measurements in children with the adult reference database was between 72% and 90%. Children’s retinal thickness was not significantly correlated with age but was positively associated with spherical equivalent.

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How does being Overweight Affect the Choroid in Children?

Duran,

Cevher,

Evin

2024

Online Türk Sağlık Bilimleri Dergisi

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How does overweight affect the choroid in children? ABSTRACT Objective: To compare the choroidal thickness (CT) and choroidal vascular index (CVI) of overweight and obese children with those of children with normal weight. Materials and Methods: Forty-four overweight and obese children and 35 children with normal weight were included in the study. After a complete ophthalmological examination of the participants, macula images were taken with optical coherence tomography and choroidal images with enhanced depth imaging mode. The fovea’s central macular thickness, subfoveal, 1000-µm nasal, and 1000-µm temporal CT were measured. Total choroidal area (TCA), luminal area (LA), and stromal area (SA) were measured using the binarization method, and the CVI was calculated by the ratio of luminal area to TCA. The participants’ right eye measurements were used in the study. Results: The mean body mass index (BMI) value of the overweight group was 27.70 ± 1.55; the mean BMI value of the obese group was 35.73 ± 3.84; and the mean BMI value of the control group was 21.56 ± 1.44. Subfoveal CT, TCA, and SA values significantly differed between the groups (p = 0.019, p = 0.016, p = 0.028, respectively). A significant positive correlation existed between BMI and subfoveal CT, TCA, and SA (r = 0.264, p = 0.019; r = 0.233, p = 0.038; r = 0.231, p = 0.041, respectively). Conclusion: This study showed that the obese group had significantly higher subfoveal CT, TCA, and SA values than the control group. In addition, a significant positive correlation was found between BMI and subfoveal CT, TCA, and SA. Keywords: choroidal thickness, choroidal vascularity index, overweight, pediatric obesity, optical coherence tomography Çocuklarda kilo fazlalığı koroidi nasıl etkiler? ÖZET Amaç: Fazla kilolu ve obez çocukların koroid kalınlığı (CT) ve koroid vasküler indeksini (CVI) normal kilolu çocuklarla karşılaştırmak. Materyal ve Metot: Çalışmaya 44 fazla kilolu ve obez çocuk ile 35 normal kilolu çocuk dahil edildi. Katılımcıların tam oftalmolojik muayenesinin ardından optik koherens tomografi ile makula görüntüleri ve geliştirilmiş derinlik görüntüleme modu ile koroid görüntüleri alındı. Foveanın merkezi makula kalınlığı, subfoveal, 1000 µm nazal ve 1000 µm temporal CT ölçüldü. Toplam koroid alanı (TCA), luminal alanı (LA) ve stromal alan (SA), ikilileştirme yöntemi kullanılarak ölçüldü ve CVI, LA’NIN TCA'ya oranıyla hesaplandı. Araştırmada katılımcıların sağ göz ölçümleri kullanıldı. Bulgular: Aşırı kilolu grubun ortalama vücut kitle indeksi (BMI) değeri 27,70 ± 1,55; obez grubun ortalama BMI değeri 35,73±3,84; kontrol grubunun ortalama BMI değeri ise 21,56±1,44 idi. Subfoveal CT, TCA ve SA değerleri gruplar arasında anlamlı farklılık gösterdi (sırasıyla p = 0,019, p = 0,016, p = 0,028). BMI ile subfoveal CT, TCA ve SA arasında anlamlı pozitif bir korelasyon mevcuttu (sırasıyla r = 0,264, p = 0,019; r = 0,233, p = 0,038; r = 0,231, p = 0,041). Sonuç: Bu çalışma obez grubun subfoveal CT, TCA ve SA değerlerinin kontrol grubuna göre anlamlı derecede yüksek olduğunu gösterdi. Ayrıca BMI ile subfoveal CT, TCA ve SA arasında anlamlı pozitif korelasyon bulundu. Anahtar Kelimeler: koroid kalınlığı, koroid vaskülarite indeksi, aşırı kilo, pediatrik obezite, optik kohorens tomografi

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Assessment of macular choroidal and retinal thickness: a cohort study in Tibetan healthy children

Cited by 3 publications

References 48 publications

Choroidal and Retinal Thicknesses in Healthy Eyes Measured with Ultra-Wide-Field Optical Coherence Tomography

Choroidal and Retinal Thicknesses in Healthy Eyes Measured with Ultra-Wide-Field Optical Coherence Tomography

Evaluating retinal thickness classification in children: A comparison between pediatric and adult optical coherence tomography databases

How does being Overweight Affect the Choroid in Children?

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