Assessment of magnetization transfer effects in myocardial tissue using balanced steady‐state free precession (bSSFP) cine MRI

Weber, O.; Speier, Peter; Scheffler, Klaus; Bieri, Oliver

doi:10.1002/mrm.22053

Cited by 42 publications

(47 citation statements)

References 31 publications

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“…19 In the second study, changes in MTR in infarct zone myocardium were observed in patients immediately after acute MI. 20 We did not observe consistent changes in infarct zone MTR during the acute phase of MI (day 1) when radiofrequency irradiation was applied on resonance. This probably results from different MT/CEST-weighting strategies between previous studies, which used high radiofrequency irradiation to maximize direct saturation of water to create positive contrast from MT, and our study which used lower radiofrequency-irradiation to limit indirect saturation of water so as to heighten detection of fibrosis at greater CEST-offset frequencies.…”

Section: Discussioncontrasting

confidence: 60%

“…D, Peak ΔMTR asym was significantly higher in mice receiving Eu-HPDO3A compared with saline controls, and was significantly higher in mice receiving Eu-HPDO3A and dobutamine compared with both the groups *P<0.05 vs Saline, †P<0.05 vs Eu-HPDO3A, and ‡P<0.05 vs 7.5 minutes). Previously, 2 studies have used MT-weighted cardiac magnetic resonance imaging (CMR) to differentiate infarcted from stunned myocardium, 19 and to visualize changes in cardiac tissue composition 20 using MT preparation with on-resonance saturation. In the first study, MT-weighted CMR of the dog heart early after surgically induced MI resulted in moderate signal enhancement in infarct zone myocardium.…”

Section: Discussionmentioning

confidence: 99%

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Cardio-Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Reveals Molecular Signatures of Endogenous Fibrosis and Exogenous Contrast Media

Vandsburger

Vandoorne

Oren

et al. 2015

Circ: Cardiovascular Imaging

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Background-Application of emerging molecular MRI techniques, including chemical exchange saturation transfer (CEST)-MRI, to cardiac imaging is desirable; however, conventional methods are poorly suited for cardiac imaging, particularly in small animals with rapid heart rates. We developed a CEST-encoded steady state and retrospectively gated cardiac cine imaging sequence in which the presence of fibrosis or paraCEST contrast agents was directly encoded into the steady-state myocardial signal intensity (cardioCEST). Methods and Results-Development of cardioCEST: A CEST-encoded cardiac cine MRI sequence was implemented on a 9.4T small animal scanner. CardioCEST of fibrosis was serially performed by acquisition of a series of CEST-encoded cine images at multiple offset frequencies in mice (n=7) after surgically induced myocardial infarction. Scar formation was quantified using a spectral modeling approach and confirmed with histological staining. Separately, circulatory redistribution kinetics of the paramagnetic CEST agent Eu-HPDO3A were probed in mice using cardioCEST imaging, revealing rapid myocardial redistribution, and washout within 30 minutes (n=6). Manipulation of vascular tone resulted in heightened peak CEST contrast in the heart, but did not alter redistribution kinetics (n=6). At 28 days after myocardial infarction (n=3), CEST contrast kinetics in infarct zone tissue were altered, demonstrating gradual accumulation of Eu-HPDO3A in the increased extracellular space. Conclusions-cardioCEST MRI enables in vivo imaging of myocardial fibrosis using endogenous contrast mechanisms, and of exogenously delivered paraCEST agents, and can enable multiplexed imaging of multiple molecular targets at highresolution coupled with conventional cardiac MRI scans. (Circ Cardiovasc Imaging. 2015;8:e002180.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Cardio-Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Reveals Molecular Signatures of Endogenous Fibrosis and Exogenous Contrast Media

Vandsburger

Vandoorne

Oren

et al. 2015

Circ: Cardiovascular Imaging

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“…(25) and that the coefficient of protons is directly related to T 1 (26). Chronic MIs are also known to have significantly reduced magnetization transfer effects (27). This could lead to an apparent increase in LGE images and native T 1 maps (E, F) in STEMI and NSTEMI patients.…”

Section: Discussionmentioning

confidence: 96%

Native T 1 Mapping by 3-T CMR Imaging for Characterization of Chronic Myocardial Infarctions

Kali

Choi

Sharif

et al. 2015

JACC: Cardiovascular Imaging

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“…Robson et al have shown that MT effects can lead to T 1 underestimation by MOLLI 48 . Scholz et al 49 and Weber et al 50 have shown that the MT effects are reduced in AMIs and CMIs, which could potentially lead to longer apparent T 1 values within infarcted myocardium. Nevertheless, further studies are necessary to fully elucidate the mechanisms and their relative contributions to the underlying T 1 elongations observed in CMIs.…”

Section: Discussionmentioning

confidence: 99%

Determination of Location, Size, and Transmurality of Chronic Myocardial Infarction Without Exogenous Contrast Media by Using Cardiac Magnetic Resonance Imaging at 3 T

Kali

Cokic

Tang

et al. 2014

Circ: Cardiovascular Imaging

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Background LGE CMR is a powerful method for characterizing MI, but the requisite gadolinium infusion is estimated to be contraindicated in nearly 20% of MI patients due to end-stage chronic kidney disease. The purpose of this study is to investigate whether T1 Cardiovascular-Magnetic-Resonance Imaging (CMR) obtained without contrast agents at 3T could be an alternative to Late-Gadolinium-Enhanced (LGE) CMR for characterizing chronic myocardial infarctions (MIs) using a canine model of MI. Methods and Results Canines (n=29) underwent CMR at 7 days (acute, AMI) and 4 months (chronic, CMI) post-MI. Infarct location, size and transmurality measured using native T1 maps and LGE images at 1.5T and 3T were compared. Resolution of edema between AMI and CMI was examined with T2 maps. T1 maps overestimated infarct size and transmurality relative to LGE images in AMI (p=0.016 and p=0.007, respectively), which was not observed in CMI (p=0.49 and p=0.81, respectively), at 3T. T1 maps underestimated infarct size and transmurality relative to LGE images in AMI and CMI (p<0.001), at 1.5T. Relative to the remote territories, T1 of the infarcted myocardium was increased in CMI and AMI (p<0.05); and T2 of the infarcted myocardium was increased in AMI (p<0.001), but not in CMI (p >0.20) at both field strengths. Histology showed extensive replacement fibrosis within the CMI territories. CMI detection sensitivity and specificity of T1 CMR at 3T were 95% and 97%, respectively. Conclusions Native T1 maps at 3T can determine the location, size and transmurality of CMI with high diagnostic accuracy. Patient studies are necessary for clinical translation.

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Assessment of magnetization transfer effects in myocardial tissue using balanced steady‐state free precession (bSSFP) cine MRI

Cited by 42 publications

References 31 publications

Cardio-Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Reveals Molecular Signatures of Endogenous Fibrosis and Exogenous Contrast Media

Cardio-Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Reveals Molecular Signatures of Endogenous Fibrosis and Exogenous Contrast Media

Native T 1 Mapping by 3-T CMR Imaging for Characterization of Chronic Myocardial Infarctions

Determination of Location, Size, and Transmurality of Chronic Myocardial Infarction Without Exogenous Contrast Media by Using Cardiac Magnetic Resonance Imaging at 3 T

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