Assessment of Medication Adherence in a Cohort of Patients with Bipolar Disorder

González-Pinto, Ana; Reed, Catherine; Novick, Danielle M.; Bertsch, Jordan; Haro, Josep María

doi:10.1055/s-0030-1263169

Cited by 53 publications

(60 citation statements)

References 48 publications

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“…Our findings are likely to reflect the difficulty of managing manic patients in outpatient care, and suggest the need for inpatient care to facilitate proper treatment, an implication further supported by the finding that mania among patients who were diagnosed with bipolar disorder in inpatient care did not predict less prescription fills of prophylactic drugs after discharge. In contrast, patients presenting with mixed state at bipolar disorder diagnosis had an increased likelihood of filling a mood-stabilizer or antipsychotic prescription, contradicting the results from a prior study on adherence in different affective states (Gonzalez-Pinto et al, 2010). The reasons for this discrepancy are not clear.…”

Section: Discussioncontrasting

confidence: 73%

Predictors for initiation of pharmacological prophylaxis in patients with newly diagnosed bipolar disorder—A nationwide cohort study

Scheen¹,

Brandt²,

Bodén³

et al. 2015

Journal of Affective Disorders

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Section: Discussioncontrasting

confidence: 73%

Predictors for initiation of pharmacological prophylaxis in patients with newly diagnosed bipolar disorder—A nationwide cohort study

Scheen¹,

Brandt²,

Bodén³

et al. 2015

Journal of Affective Disorders

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“…New data provide further insight into adherence to maintenance therapy in patients with BD. In several analyses, adherence was positively associated with higher satisfaction with medication, monotherapy, a college degree, and fear of relapse, and was negatively associated with illness factors (substance use, previous hospitalization, psychotic symptoms, reduced insight into illness), medication factors (side effects, no perceived daily benefit, difficulties with medication routines), and patient attitudes (belief that medications are unnecessary, negative attitudes toward medications, perceived change in appearance, perceived interference with life goals) (133)(134)(135)(136)(137)(138)(139). Under-dosing can also lead to higher discontinuation rates; patients receiving lower doses of ziprasidone had significantly higher discontinuation rates than those receiving medium or high doses (140).…”

Section: Clinical Questions and Controversiesmentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013

et al. 2012

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Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Beaulieu S, Alda M, O’Donovan C, MacQueen G, McIntyre RS, Sharma V, Ravindran A, Young LT, Milev R, Bond DJ, Frey BN, Goldstein BI, Lafer B, Birmaher B, Ha K, Nolen WA, Berk M.  Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013.  Bipolar Disord 2012: 00: 000–000. © 2012 John Wiley & Sons A/S.Published by Blackwell Publishing Ltd.The Canadian Network for Mood and Anxiety Treatments published guidelines for the management of bipolar disorder in 2005, with updates in 2007 and 2009. This third update, in conjunction with the International Society for Bipolar Disorders, reviews new evidence and is designed to be used in conjunction with the previous publications.The recommendations for the management of acute mania remain largely unchanged. Lithium, valproate, and several atypical antipsychotic agents continue to be first‐line treatments for acute mania. Monotherapy with asenapine, paliperidone extended release (ER), and divalproex ER, as well as adjunctive asenapine, have been added as first‐line options.For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, as well as olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or divalproex plus SSRI/bupropion remain first‐line options. Lurasidone monotherapy and the combination of lurasidone or lamotrigine plus lithium or divalproex have been added as a second‐line options. Ziprasidone alone or as adjunctive therapy, and adjunctive levetiracetam have been added as not‐recommended options for the treatment of bipolar depression. Lithium, lamotrigine, valproate, olanzapine, quetiapine, aripiprazole, risperidone long‐acting injection, and adjunctive ziprasidone continue to be first‐line options for maintenance treatment of bipolar disorder. Asenapine alone or as adjunctive therapy have been added as third‐line options.

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“…Rosa et al (42) reported in their study that 85.6% of their patients with bipolar disorder were compliant with lithium treatment. GonzalezPinto et al (43) started to follow up 1831 patients in the first 12 weeks of treatment and continued for 24 months, and they showed that 76.6% were treatment compliant, but 23.4% were treatment incompliant. Study results and the literature findings were different from each other, because methods to evaluate compliance were different, sample size contained patients with additional psychiatric diagnosis, sample size, follow-up duration for patient compliance, there were ethnically different groups, and differences between healthcare politics of the studies performed.…”

Section: Discussionmentioning

confidence: 99%

Relationship between drug compliance, coping with stress, and social support in patients with bipolar disorder

Aksoy¹,

Kelleci²

2016

Dusunen Adam

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Relationship between drug compliance, coping with stress, and social support in patients with bipolar disorder Objective: In bipolar disorder, recurrence rate is relatively high. With each episode, the risk of a new episode is increased. The first choice is drug treatment. However, patients have serious difficulties in drug compliance. This study was conducted to investigate drug compliance of patients with bipolar disorder, and to determine relationships between drug compliance, coping with stress, and social support. Method: The target population of the study included 280 patients registered in a state hospital with the diagnosis of bipolar disorder in 2011, residing in the city center, and having no other psychiatric disorders. Of these 280 patients, 150 who agreed to participate in the study and accepted to be visited at home after they were telephoned comprised the study sample. Of the patients in the target population, phone numbers and addresses were changed in 112 patients, and 18 refused to have a home-visit, so they were excluded from the study. Data were collected using the personal information form, Morisky Medication Adherence Scale, Multidimensional Scale of Perceived Social Support and Ways of Coping Scale. Results: In this study, it was determined that 55.3% of the patients did not comply with drug treatment. The patients with poor drug compliance preferred mainly desperate approach and submissive approach subdimensions of the Ways of Coping Scale more. There was no difference between patients with and without drug compliances in terms of social support. Conclusions: It is considered that development of effective coping strategies would promote drug compliance in patients with bipolar disorder. Keywords: Bipolar disorder, coping, medication compliance, nursing, social support ÖZET Bipolar hastalarda ilaç uyumunun stresle başetme ve sosyal destekle ilişkisi Amaç: Bipolar bozukluğun tekrarlama oranı oldukça yüksektir. Geçirilen her atak yeni bir atak geçirme riskini arttırır. Tedavide ilk seçenek ilaç tedavisidir. Ancak hastaların ilaç tedavisine uyumla ilgili ciddi sorunları bulunmaktadır. Bu çalışma bipolar hastaların ilaç uyumunu belirlemek, stresle başetme ve sosyal destekle ilişkisini incelemek amacı ile yapılmıştır. Yöntem: Araştırmanın evrenini bir devlet hastanesine 2011 yılında bipolar bozukluk tanısı ile kayıtlı olan, il merkezinde yaşayan, ek psikiyatrik tanısı olmayan 280 hasta, örneklemi ise telefonla aranarak araştırmaya katılmayı ve ev ziyaretini kabul eden 150 hasta oluşturdu. Evreni oluşturan hastalardan 112 kişiye telefon ve adres değişikliği, 18 kişiye ise ev ziyaretini kabul etmeme nedeni ile ulaşılamamıştır. Veriler, "Kişisel Bilgi Formu", "Morisky Uyum Ölçeği", "Çok Boyutlu Algılanan Sosyal Destek Ölçeği" ve "Stresle Başa Çıkma Tarzları Ölçeği" ile toplandı. İlaç uyumu iyi olan ve ilaç uyumu olmayan hastalar stresle baş etme biçimleri ve sosyal destek puanları açısından karşılaştırıldı. Bulgular: Çalışmada hastaların %55.3'ünün ilaç tedavisine uyumsuz olduğu belirlendi...

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Assessment of Medication Adherence in a Cohort of Patients with Bipolar Disorder

Abstract: Psychotic symptoms, poor insight, cannabis abuse/dependence and work impairment are negatively related to medication adherence during maintenance therapy of bipolar disorder. Patients with these characteristics may need a different therapeutic approach.

Cited by 53 publications

References 48 publications

Predictors for initiation of pharmacological prophylaxis in patients with newly diagnosed bipolar disorder—A nationwide cohort study

Predictors for initiation of pharmacological prophylaxis in patients with newly diagnosed bipolar disorder—A nationwide cohort study

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013

Relationship between drug compliance, coping with stress, and social support in patients with bipolar disorder

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