This chapter delves into the multifaceted issue of urban pollution and its significant health impacts, with a particular focus on the roles of ophthalmology and radiology. It explores the various sources and types of urban pollution, such as air, water, noise, and light pollution, and their detrimental effects on public health. Special attention is given to how pollution contributes to eye health problems, including allergies, dry eye syndrome, and conjunctivitis, as well as its impact on vision due to light pollution. The chapter also highlights the critical role of radiological imaging in diagnosing pollution-related diseases, such as chronic respiratory and cardiovascular conditions. By examining case studies, epidemiological data, and the latest technological and medical interventions, this chapter aims to provide a comprehensive understanding of the environmental challenges faced by modern cities and proposes interdisciplinary approaches for effective management and prevention.