Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease

Bennett, Jonathan; van Dinther, Maud; Voorter, Paulien; Backes, Walter; Barnes, Josephine; Barkhof, Frederick; Captur, Gabriella; Hughes, Alun D.; Sudre, Carole; Treibel, Thomas A.

doi:10.3390/medicina59091596

Cited by 2 publications

(1 citation statement)

References 126 publications

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“…Created with BioRender.com . MRI images adapted from Bennett et al 206 used under CC BY 4.0. cSVD indicates cerebral small vessel disease; and MRI, magnetic resonance imaging.…”

Section: Discussionmentioning

confidence: 99%

Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis

Scheuermann,

Parr,

Schulze

et al. 2023

JAHA

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Background Cerebral small vessel disease (cSVD) is a major contributing factor to ischemic stroke and dementia. However, the vascular pathologies of cSVD remain inconclusive. The aim of this systematic review and meta‐analysis was to characterize the associations between cSVD and cerebrovascular reactivity (CVR), cerebral autoregulation, and arterial stiffness (AS). Methods and Results MEDLINE, Web of Science, and Embase were searched from inception to September 2023 for studies reporting CVR, cerebral autoregulation, or AS in relation to radiological markers of cSVD. Data were extracted in predefined tables, reviewed, and meta‐analyses performed using inverse‐variance random effects models to determine pooled odds ratios (ORs). A total of 1611 studies were identified; 142 were included in the systematic review, of which 60 had data available for meta‐analyses. Systematic review revealed that CVR, cerebral autoregulation, and AS were consistently associated with cSVD (80.4%, 78.6%, and 85.4% of studies, respectively). Meta‐analysis in 7 studies (536 participants, 32.9% women) revealed a borderline association between impaired CVR and cSVD (OR, 2.26 [95% CI, 0.99–5.14]; P =0.05). In 37 studies (27 952 participants, 53.0% women) increased AS, per SD, was associated with cSVD (OR, 1.24 [95% CI, 1.15–1.33]; P <0.01). Meta‐regression adjusted for comorbidities accounted for one‐third of the AS model variance ( R 2 =29.4%, P moderators =0.02). Subgroup analysis of AS studies demonstrated an association with white matter hyperintensities (OR, 1.42 [95% CI, 1.18–1.70]; P <0.01). Conclusions The collective findings of the present systematic review and meta‐analyses suggest an association between cSVD and impaired CVR and elevated AS. However, longitudinal investigations into vascular stiffness and regulatory function as possible risk factors for cSVD remain warranted.

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“…Created with BioRender.com . MRI images adapted from Bennett et al 206 used under CC BY 4.0. cSVD indicates cerebral small vessel disease; and MRI, magnetic resonance imaging.…”

Section: Discussionmentioning

confidence: 99%

Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis

Scheuermann,

Parr,

Schulze

et al. 2023

JAHA

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Evaluation of the results of magnetic resonance imaging of the brain for cognitive impairment in patients with heart failure: A review

Shariya,

Ustyuzhanin,

Zhirov

et al. 2024

Terapevticheskii arkhiv

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Cognitive impairment is a very common comorbidity in patients with heart failure (HF). Patients with HF show signs of memory decline, difficulty concentrating, and attention deficits. Cognitive dysfunction in HF is associated with a poor prognosis. However, the diagnosis of cognitive impairment in heart failure has received insufficient attention in routine clinical practice. Neuropsychological screening tests are available to screen for cognitive impairment, but they are used infrequently. Therefore, it is of practical interest to search for magnetic resonance equivalents of cognitive disorders. The use of magnetic resonance imaging as a tool for identifying and quantifying neural correlates of cognitive functions is discussed.

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Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease

Cited by 2 publications

References 126 publications

Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis

Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis

Evaluation of the results of magnetic resonance imaging of the brain for cognitive impairment in patients with heart failure: A review

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