Assessment of molybdenum toxicity in humans

Vyskočil, Adolf; Viau, Claude

doi:10.1002/(sici)1099-1263(199905/06)19:3<185::aid-jat555>3.0.co;2-z

Cited by 196 publications

(124 citation statements)

References 36 publications

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“…On the other hand, cobalt, chromium and molybdenum are cofactors for a number of enzymes and are essential trace metals, but can become toxic after a minimal increase in concentration (Rae 1981, Vyskocil andViau 1999). Despite the concern that chronically elevated serum chromium and cobalt concentrations may result in adverse long-term biological effects, the issue of clinical relevance must be critically discussed.…”

Section: Discussionmentioning

confidence: 99%

Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty

et al. 2006

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(2006) Exposure to chromium, cobalt and molybdenum from metal-onmetal total hip replacement and hip resurfacing arthroplasty, Acta Orthopaedica, 77:5, Background All metal implants-and metal-on-metal bearings in particular-corrode and cause a release of metal ions. Because cobalt and chromium have been shown to be carcinogenic and mutagenic in human and animal models, systemic toxicity and cancer risk are considered to be possible disadvantages of the metal-onmetal articulation.This study was designed to investigate the serum concentration profiles of chromium, cobalt and molybdenum after implantation of a Birmingham hip resurfacing arthroplasty (BHR) and a cementless total hip replacement with a 28-mm Metasul articulation (MTHR), over the first 2 years after implantation.Methods We analyzed profiles of metal ion serum levels in 111 patients implanted with a BHR, in 74 patients implanted with an MTHR, and in 130 implantfree probands control subjects using atomic absorption spectrophotometry.Results Chromium and cobalt concentrations (in µg/L) of all BHR and MTHR patients differed significantly from those of control subjects (chromium: < 0.25; cobalt: 0.25). The median chromium and cobalt concentrations in BHR patients had increased to 5.1 and 4.3 µg/ L 2 years after surgery. Concentrations in BHR patient exceeded those in the unilateral MTHR patients. Molybdenum serum concentrations hardly changed over time in either group and were not significantly different from the concentrations seen in the control subjects.Interpretation During the first 2 years after surgery, the Birmingham hip resurfacing arthroplasty leads to

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Section: Discussionmentioning

confidence: 99%

Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty

et al. 2006

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“…In Japan, the concentration of molybdenum in environmental waters, such as drinking, river, and seawaters, were reported to be 0.11-6.2, 1, and 10 ppb, respectively [5][6]. Accordingly, precise and accurate, as well as selective separation and sensitive analytical methods for the determination of molybdenum in environmental samples should be developed.…”

Section: Introductionmentioning

confidence: 99%

Functionalization of chitosan with 3-nitro-4-amino benzoic acid moiety and its application to the collection/concentration of molybdenum in environmental water samples

Sabarudin

Oshima

Noguchi

et al. 2007

Talanta

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A chitosan resin functionalized with 3-nitro-4-amino benzoic acid moiety (CCTS-NABA resin) was newly synthesized for the collection/concentration of trace molybdenum by using cross-linked chitosan (CCTS) as base material. The carboxyl group of the moiety was chemically attached to amino group of cross-linked chitosan through amide bond formation.The adsorption behavior of molybdenum as well as other 60 elements on the resin was examined by passing the sample solutions through a mini-column packed with the resin. After the elution of the elements collected on the resin with 1 M HNO 3 , the eluates were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) and -atomic emission spectrometry (ICP-AES).The CCTS-NABA resin can adsorb several metal ions, such as vanadium, gallium, arsenic, selenium, silver, bismuth, thorium, tungsten, tin, tellurium, copper, and molybdenum at appropriate pHs. Among these metal ions, only molybdenum could be adsorbed almost completely on the resin at acidic regions. An excellent selectivity toward molybdenum could be obtained at pH 3-4. The adsorption capacity of CCTS-NABA resin for Mo (VI) was 380 mg g -1 resin. Through the column pretreatment, alkali and alkaline earth metals in river water and seawater samples were successfully removed.The CCTS-NABA resin was applied to the adsorption/collection of Molybdenum in river water and seawater samples. The Concentrations of molybdenum in river water samples were found in the range of 0.84 and 0.95 ppb (ng g -1 ), whereas molybdenum in seawater was about 9 ppb. The validation of the proposed method was carried out by determining molybdenum in the certified reference materials of SLRS-4, CASS-4, and NASS-5 after passing through the CCTS-NABA resin; the results showed good agreement with the certified values.

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“…Animals exposed to molybdenum in drinking water or while foraging for plants are likely to suffer from molybdenosis or reflect copper deficiency [Raisbeck et al 2006]. Humans exposed to molybdenum in food [Vyskocil and Viau 1999] or circumstances releasing high levels of molybdenum [Titenko-Holland et al 1998;Kargar et al 2011;Yu et al 2011] are likely to suffer from anemia, anorexia, profound diarrhea, gout-like disease, reduced sexual activity [EVM 2000], and neural tube defects [Huang et al 2011].…”

Section: Introductionmentioning

confidence: 60%

The effect of molybdenum on thein vitrodevelopment of mouse preimplantation embryos

Zhang

Liu

et al. 2012

Systems Biology in Reproductive Medicine

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The object of this study was to investigate the effect of molybdenum on the development of mouse preimplantation embryos cultured in vitro. Zygotes were flushed from one outbred mouse strain (Kunming), and then were cultured in potassium simplex optimized medium (KSOM) containing 0, 5, 10, 20, 40, 80, 120, and 160 µg/ml of molybdenum for 5 days until the midblastocyst stage. The addition of ≤ 20 µg/ml molybdenum did not affect the blastocyst and birth rates. Molybdenum at doses of 40 µg/ml and higher significantly decreased the cleavage, blastocyst and birth rates, the average cell number, and significantly increased the proportion of degenerative blastocysts. At 120 µg/ml molybdenum inhibited the blastocysts development to birth. At 160 µg/ml molybdenum caused overall developmental arrest (up to 16-cells) of embryos and their massive degeneration. In conclusion, molybdenum negatively affected the development of embryos in a dose-dependent manner. With lower doses (≤ 20 µg/ml), mouse embryos were not apparently damaged. With very high doses (≥ 40 µg/ml), embryo quality significantly decreased. This assessment of the effect of molybdenum on the preimplantation embryo is an initial survey of toxicological risk.

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Assessment of molybdenum toxicity in humans

Cited by 196 publications

References 36 publications

Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty

Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty

Functionalization of chitosan with 3-nitro-4-amino benzoic acid moiety and its application to the collection/concentration of molybdenum in environmental water samples

The effect of molybdenum on thein vitrodevelopment of mouse preimplantation embryos

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