Assessment of Monocyte/HDL Ratio in Branch Retinal Vein Occlusion

Şatırtav, Günhal; Mirza, Enver; Oltulu, Refik; Mirza, Günsu Deniz; Kerimoğlu, Hürkan

doi:10.1080/09273948.2019.1569244

Cited by 24 publications

(21 citation statements)

References 33 publications

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“…In the first study, Mirza et al (26) found high MHR values in glaucoma patients. In the second one, MHR level was high in patients with retinal venous occlusion (27). Thus, our study is the first one that investigates the relation between diabetic retinopathy and MHR.…”

Section: Discussionmentioning

confidence: 74%

Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in diabetic retinopathy

Kan

Karaibrahimoğlu

2020

Journal of Health Sciences and Medicine

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Amaç: Diyabetik retinopatisi olan hastalarda kardiyovasküler hastalıkların artan sıklığı bilinmektedir. MHO (Monosit/HDL oranı), kardiyovasküler ve serebrovasküler hastalıklarla ilişkisi yeni saptanmış bir belirteçtir. Bu çalışmanın amacı aşikar kardiyovasküler hastalık bulgusu olmayan diyabetik retinopatisi olan hastalarda subklinik ateroskleroz risk göstergesi karotis intima media kalınlığı (KİMK) ile MHO ilşkisini araştırmaktır. Gereç ve Yöntem: Aşikar kardiyovasküler hastalığı olmayan 106 diyabetik hasta ve 35 yaş, cinsiyet ve BMI (body mass index) ile uyumlu sağlıklı kontrol alındı. Hastalar proliferatif diyabetik retinopati (PDR, n=30), nonproliferatif diyabetik retinopati (NPDR, n=35), retinopati olmayan diyabet hastaları (n=41) ve kontrol grubu (n=35) olmak üzere dört gruba ayrıldı. Antropometrik, biyokimyasal parametreler ve KİMK ölçüldü. MHO ile KİMK arasındaki ilişkiyi değerlendirmek için korelasyon ve regresyon analizi yapıldı. Bulgular: MHO değerleri gruplar arasında anlamlı farklılığa sahip ve PDR grubunda anlamlı düzeyde daha yüksekti (p<0.001). Ateroskleroz göstergesi olan KİMK gruplar arasında anlamlı farklılık gösterdi (p<0.001). KİMK değeri PDR grubunda anlamlı düzeyde yüksek iken diğer gruplarda birbirine yakın değerler ölçüldü. PDR grubunda MHO ile KİMK arasında önemli düzeyde anlamlı korelasyon bulundu (r=0,96; p<0.001). Binary logistic regression analizinde MHO'nin KİMK üzerine anlamlı etkisi bulunmaktaydı [β=0,206, (%95 CI: 1,004-1,505), p=0,046]. Sonuç: Bu çalışma, yüksek MHO'nın diyabetik retinopatisi olan hastalarda subklinik kardiyovasküler riski belirlemede non-invaziv, basit ve maliyeti düşük bir marker olarak kullanılabileceğini göstermektedir. Diyabetik retinopatide MHO ve KİMK arasındaki ilişkiyi inceleyen literatürdeki ilk çalışma olan bu çalışma, aşikar kardiyovasküler hastalık bulgusu olmayan diyabetik hastalardaki kardiyak riski erken belirlemede fayda sağlayabilir.

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Section: Discussionmentioning

confidence: 74%

Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in diabetic retinopathy

Kan

Karaibrahimoğlu

2020

Journal of Health Sciences and Medicine

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“…demonstrated that the MHR was significantly higher in patients with than without pseudoexfoliation syndrome or glaucoma. [ 18 19 20 36 ] In addition, Satirtav et al . found that increased MHRs significantly related to branch retinal vein occlusion.…”

Section: Discussionmentioning

confidence: 99%

“…found that increased MHRs significantly related to branch retinal vein occlusion. [ 20 ] In both articles, the authors reported that MHR was elevated due to increased systemic inflammation. Nevertheless, no investigation of MHRs in patients with CSC had been conducted prior to our study.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have also demonstrated that monocyte-to-HDL ratios (MHR) are relatively high in several systemic and ocular disorders associated with inflammation including ischemic stroke, coronary artery stenosis, pseudoexfoliation syndrome or glaucoma, and branch retinal vein occlusion. [ 17 18 19 20 ]…”

mentioning

confidence: 99%

“…Although MHR has been studied in several diseases related to systemic and local inflammation, such as branch retinal vein occlusion, diabetic retinopathy, and exfoliation syndrome, its association with CSC has not been reported yet. [ 19 20 21 ] Since the pathogenesis of CSC seems to be related to systemic inflammation, we aimed to investigate whether elevated MHRs and NLRs are important predictors of CSC. To our knowledge, our study marks the first to have involved the evaluation of MHRs in patients with CSC.…”

mentioning

confidence: 99%

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Monocyte to high-density lipoprotein and neutrophil-to-lymphocyte ratios in patients with acute central serous chorioretinopathy

Sırakaya

Duru

Küçük

et al. 2020

Indian J Ophthalmol

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Purpose: To investigate monocyte to high-density lipoprotein (HDL) ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) as indicators of systemic inflammation in acute central serous chorioretinopathy (CSC). Methods: The HDL levels, hematological profiles, erythrocyte sedimentation rates (ESR), and C-reactive protein (CRP) levels of 38 patients with acute CSC (Group I) and 38 controls without CSC (Group II) were measured. Results: MHRs were significantly higher in Group I (13.30 ± 2.95) than in Group II (11.52 ± 2.42, P = 0.005), whereas NLRs, CRP values, and ESR values did not significantly differ between the groups ( P = 0.726, P = 0.219, and P = 0.441, respectively). Multivariate analysis revealed that the MHR was an independent predictor of acute CSC (OR = 1.266, 95% CI = 1.054-1.521, P = 0.012). Conclusion: Indicating an association between increased MHRs and acute CSC, the MHR might represent simple, inexpensive, reliable biomarkers of inflammation in acute CSC.

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Monocyte-to-high-density lipoprotein ratio and systemic immune-inflammation index: Potential parameters for the evaluation of disease activity and severity in Graves’ ophthalmopathy?

Yılmaz Tuğan,

Ergen,

Özkan

2024

Int Ophthalmol

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Assessment of Monocyte/HDL Ratio in Branch Retinal Vein Occlusion

Cited by 24 publications

References 33 publications

Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in diabetic retinopathy

Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in diabetic retinopathy

Monocyte to high-density lipoprotein and neutrophil-to-lymphocyte ratios in patients with acute central serous chorioretinopathy

Monocyte-to-high-density lipoprotein ratio and systemic immune-inflammation index: Potential parameters for the evaluation of disease activity and severity in Graves’ ophthalmopathy?

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